PLOS 07/06/12 Q Fever and Pneumonia in an Area with a High Livestock Density: A Large Population-Based Study Concerns about public health risks of intensive animal production in the Netherlands continue to rise, in particular related to outbreaks of infectious diseases. The aim was to investigate associations between the presence of farm animals around the home address and Q fever and pneumonia. Electronic medical record data for the year 2009 of all patients of 27 general practitioners (GPs) in a region with a high density of animal farms were used. Density of farm animals around the home address was calculated using a Geographic Information System. A high density of goats in a densely populated region was associated with human Q fever. Figures Citation: Smit LAM, van der Sman-de Beer F, Opstal-van Winden AWJ, Hooiveld M, Beekhuizen J, et al. (2012) Q Fever and Pneumonia in an Area with a High Livestock Density: A Large Population-Based Study. Editor: Joan A. Received: January 17, 2012; Accepted: May 11, 2012; Published: June 7, 2012 Copyright: © 2012 Smit et al. Introduction Methods Figure 1.
THE LANCET 04/02/12 Treatment of Helicobacter pylori in Latin America In their multisite study, Robert Greenberg and colleagues1 attempted to identify a reliably effective treatment for Helicobacter pylori for use in Latin America. Each study site used locally available drugs and the regimens all contained clarithromycin or clarithromycin—metronidazole, despite the unacceptably low success of triple therapies elsewhere and a high expected prevalence of metronidazole resistance.2 The success of treatments for infectious diseases is mainly related to the absence of antimicrobial resistance and is predictable if one knows the pattern of resistance and the effect of resistance on the regimens tested.3, 4 Results of seven pilot studies done in six different countries with triple therapy Treatment result grade also shown. Grade A/B=good, C=acceptable, F=unacceptable. Overall, the study was well done but poorly conceived, confirming the old adage: “there is no right way to do the wrong thing”.
Tropical Animal Health and Production - 2012 - Serosurvey and molecular detection of Crimean–Congo hemorrhagic fever virus (CCHF In this study, the hard ticks, whole blood and serum samples collected from small ruminants (sheep and goat) in middle Black Sea region of Turkey where Crimean–Congo hemorrhagic fever (CCHF) human cases were observed in the past years were surveyed for the presence of RNA and specific IgG antibodies from CCFH virus (CCHFV). CCHFV RNA was found in 30 of 255 tick pools (11.76%) and nine of 105 (8.57%) leucocyte samples. No CCHFV genomic RNA was detected from animals in Yildizeli and Vezirkopru. However, CCHFV RNA was found from animals in Gerze and Resadiye.
PLOS 10/01/18 Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials (concerne Helicobacter pilory) (avertissement de PLOS : This is an uncorrected proof.) Abstract Urease as a potential target of antimicrobial drugs has received considerable attention given its versatile roles in microbial infection. Development of effective urease inhibitors, however, is a significant challenge due to the deeply buried active site and highly specific substrate of a bacterial urease. Conventionally, urease inhibitors are designed by either targeting the active site or mimicking substrate of urease, which is not efficient. Up to now, only one effective inhibitor—acetohydroxamic acid (AHA)—is clinically available, but it has adverse side effects. Herein, we demonstrate that a clinically used drug, colloid bismuth subcitrate, utilizes an unusual way to inhibit urease activity, i.e., disruption of urease maturation process via functional perturbation of a metallochaperone, UreG. Author summary Academic Editor: Matthew Waldor, Brigham and Women's Hospital, United States of America Copyright: © 2018 Yang et al. Introduction Results Fig 1. Fig 2. Fig 3. Fig 4.
Eurosurveillance, Volume 11, Issue 29, 20 July 2006 Increase in cases of Crimean-Congo haemorrhagic fever, Turkey, 2006 Between 1 January and 30 June 2006, 323 people in Turkey underwent investigation for Crimean-Congo haemorrhagic fever (CCHF) virus infection . Among these, 150 cases were laboratory confirmed using enzyme-linked immunosorbent assay (ELISA) and real-time PCR tests. These laboratory-confirmed cases, including 11 fatal cases, were reported from 22 Turkish provinces. No cases have been reported from popular tourist resorts on the Mediterranean coast. Figure 1. Control measures implemented in Turkey Turkey’s Ministry of Health has implemented control measures, in collaboration with the Ministries of the Environment and of Agriculture and Rural Affairs, and enhanced CCHF surveillance has been established nationwide. Crimean-Congo haemorrhagic fever CCHF viral infections are endemic in many countries in Africa, eastern Europe and Asia, and occur also in the Middle East. People who have travelled to any endemic area and develop symptoms after a tick bite should contact their physician.
MICROBIOLOGY AUSTRALIA 18/09/13 Q fever: pets, vets and validating tests Download PDF Article Published: 18 September 2013 , A C A and B Q fever is a highly significant worldwide zoonosis caused by the bacterium Coxiella burnetii. While infection is commonly asymptomatic, 40% of primary infections in humans are symptomatic, with serious acute or chronic debilitating illnesses possible, including endocarditis, post-Q fever fatigue syndrome and recrudescent granulomatous lesions in bone or soft tissue1,2. The bacterium itself has a duplicitous lifecycle; a metabolically active form obligately replicates within the macrophage cell lineage while an inactive form has extreme environmental resilience, providing a means to travel to new cells and new hosts. Q fever has been traditionally framed as an occupational disease, associated with contact with cattle, sheep and goats in the livestock and meat industries. References Biographies Dr Katrina Bosward is a Senior Lecturer in Veterinary Microbiology at the Faculty of Veterinary Science, The University of Sydney.
World J Gastroenterol 2012 May 7; 18(17): 2105-2111 Study of Helicobacter pylori genotype status in saliva, dental plaques, stool and gastric biopsy samples CDC EID - MARS 2014 - Crimean-Congo Hemorrhagic Fever among Health Care Workers, Turkey Author affiliations: Ankara Numune Training and Research Hospital, Ankara, Turkey (A.K. Celikbas, B. Dokuzoğuz, N. Suggested citation for this article Abstract We investigated 9 cases of Crimean-Congo hemorrhagic fever (1 fatal, 2 asymptomatic) among health care workers in Turkey. Crimean-Congo hemorrhagic fever (CCHF) has been described from Africa, Asia, southeastern Europe, and the Middle East (1). The 9 HCWs and all CCHF patients under their care were admitted to the Infectious Diseases and Clinical Microbiology clinic (IDCM) of Ankara Numune Education and Research Hospital (Ankara, Turkey) during 2004–2011 with confirmed CCHF. Episode 1 In 2005, CCHFV infection was diagnosed in a woman on the day of delivery by cesarean section. After this episode, the index patient’s contacts were traced. Episode 2 In 2006, a nurse received a needlestick injury during a phlebotomy of a CCHFV-infected patient. Episode 3 Episode 4 Episodes 5 and 6 References Tables
PLOS 15/05/15 The Recent Evolution of a Maternally-Inherited Endosymbiont of Ticks Led to the Emergence of the Q Fever Pathogen, Coxiella burnetii Abstract Q fever is a highly infectious disease with a worldwide distribution. Its causative agent, the intracellular bacterium Coxiella burnetii, infects a variety of vertebrate species, including humans. Its evolutionary origin remains almost entirely unknown and uncertainty persists regarding the identity and lifestyle of its ancestors. Author Summary How virulent infectious diseases emerge from non-pathogenic organisms is a challenging question. Citation: Duron O, Noël V, McCoy KD, Bonazzi M, Sidi-Boumedine K, Morel O, et al. (2015) The Recent Evolution of a Maternally-Inherited Endosymbiont of Ticks Led to the Emergence of the Q Fever Pathogen, Coxiella burnetii. Editor: Jason L. Received: January 20, 2015; Accepted: April 17, 2015; Published: May 15, 2015 Copyright: © 2015 Duron et al. Competing interests: The authors have declared that no competing interests exist. Introduction ‘Query fever’ (Q fever) is a highly infectious zoonotic disease first identified in 1937 [1,2,3,4,5].
World J Gastrointest Pharmacol Ther. 2016 Feb 6;7(1):126-32. Helicobacter pylori and its reservoirs: A correlation with the gastric infection. Helicobacter pylori (H. pylori) is a gram-negative and microaerophilic bacterium that has been associated with some certain diseases, including chronic gastritis, peptic ulcers, gastric cancer, and mucosa-associated lymphoid tissue (MALT) lymphoma. In 1994, the International Agency for Research on Cancer of the World Health Organization defined H. pylori as a Group 1 carcinogen[1,2]. It is estimated that the H. pylori is present in the stomachs of 50% of the world’s population, but despite this high prevalence, we do not yet clearly understand its transmission. Possible routes are oral-oral and fecal-oral, but no consensus has been reached. Currently, the main area of research into natural reservoirs for H. pylori has included oral H. pylori with gastric infection and the presence of H. pylori in the stomach[1,4]. Several previous studies reported success in diagnosing H. pylori from oral samples from dental plaque, saliva, tongue, tonsil tissue and root canals. Tongue