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What is GenBank? GenBank ® is the NIH genetic sequence database, an annotated collection of all publicly available DNA sequences (Nucleic Acids Research, 2013 Jan;41(D1):D36-42). GenBank is part of the International Nucleotide Sequence Database Collaboration , which comprises the DNA DataBank of Japan (DDBJ), the European Molecular Biology Laboratory (EMBL), and GenBank at NCBI. These three organizations exchange data on a daily basis. The complete release notes for the current version of GenBank are available on the NCBI ftp site. A new release is made every two months. An annotated sample GenBank record for a Saccharomyces cerevisiae gene demonstrates many of the features of the GenBank flat file format. Access to GenBank There are several ways to search and retrieve data from GenBank. GenBank Data Usage The GenBank database is designed to provide and encourage access within the scientific community to the most up to date and comprehensive DNA sequence information. Confidentiality Privacy

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News Bulletin of International HoloGenomics Society Table of Contents For archived HoloGenomics News articles see Archives above Latest News UniProtKB/TrEMBL Release Statistics UniProtKB/TrEMBL PROTEIN DATABASE RELEASE 2014_04 STATISTICS 1. INTRODUCTION Release 2014_04 of 16-Apr-2014 of UniProtKB/TrEMBL contains 54958551 sequence entries, comprising 17473872940 amino acids. 759560 sequences have been added since release 2014_03, the sequence data of 13762 existing entries has been updated and the annotations of 16654879 entries have been revised. This represents an increase of 2%. Number of fragments: 5207483 Protein existence (PE): entries % 1: Evidence at protein level 22220 0.04% 2: Evidence at transcript level 856181 1.56% 3: Inferred from homology 13964112 25.41% 4: Predicted 40116038 72.99% 5: Uncertain 0 0.00% The growth of the database is summarized below. 2.

Patent EP2525649A2 - Excision of transgenes in genetically modified organisms - Google Patents This application claims the benefit of U.S. Provisional Patent Application Serial No. 61/297,628, filed January 22, 2010, titled "Excision of Transgenes in Genetically Modified Organisms." The invention generally relates to compositions and methods for generating transgenic plants. In certain embodiments, the transgenic plants comprise one or more transgenes of interest. In certain embodiments, excision of trans gene(s) is directed in pollen and/or seed, such that the pollen and/or seed produced by a transgenic plant of the invention is substantially free of transgene(s). In some embodiments, transgenic plants of the invention are useful, for example, in achieving bioconfinement of trans gene(s) of interest in the transgenic plant.

Smarter Than Us What happens when machines become smarter than humans? Forget lumbering Terminators. The power of an artificial intelligence (AI) comes from its intelligence, not physical strength and laser guns. Humans steer the future not because we’re the strongest or the fastest but because we’re the smartest. DNA Stores MLK's Speech, Shakespeare's Sonnets A team of scientists in the U.K. has encoded text, sound files and a photograph onto strings of DNA, and successfully retrieved it without errors. Nick Goldman and Ewan Birney of the European Bioinformatics Institute at the European Molecular Biology Laboratory used DNA to store a set of Shakespeare's sonnets, a recording of Martin Luther King's "I Have a Dream" speech, a photograph of the laboratory and an early research paper by James Watson and Francis Crick, who discovered DNA. Goldman and Birney then read back the data with 100 percent accuracy.

Bioinformatics Tools for Pairwise Sequence Alignment Pairwise Sequence Alignment is used to identify regions of similarity that may indicate functional, structural and/or evolutionary relationships between two biological sequences (protein or nucleic acid). By contrast, Multiple Sequence Alignment (MSA) is the alignment of three or more biological sequences of similar length. From the output of MSA applications, homology can be inferred and the evolutionary relationship between the sequences studied. Global Alignment researchers produce first complete computer model of an organism July 19, 2012 A mammoth effort has produced a complete computational model of the bacterium Mycoplasma genitalium, opening the door for biological computer-aided design. By Max McClure

Scientific collections The DNA Bank of Senckenberg and BiK-F Molecular data, particularly DNA sequences, are increasingly important for biosystematics, ecology and nature conservation. DNA sequences and fingerprints is routinely generated by many research groups because some of the most interesting questions about the evolution of life or the interactions between organisms in ecosystems cannot be answered without such data. The Senckenberg Research Institute and Natural History Museum (SGN) houses millions of collections that form a huge archive for basic research in this field. At room temperature, DNA slowly degrades. It is technically difficult to isolate intact DNA from old museum collections.

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