A method for positive forensic identification of samples from extremely low-coverage sequence data | BMC Genomics | Full Text Two loci are in linkage disequilibrium (LD) if their alleles are not randomly associated . As the name implies, LD can occur because alleles that are physically linked and nearby on chromosomes are often co-inherited. This non-random association implies that observing the allelic state of one locus provides some information about the state of the other. Our approach is based on the idea that observations of alleles made in one sample consistently provide information about the allelic state in another sample via LD if and only if the samples are from the same individual (or from a genetically identical individual, i.e., a monozygotic twin). On the other hand, when comparing data from samples from unrelated individuals, each sample provides no predictive information about alleles in the other sample. Consider a pair of SNP loci in physical proximity on the same chromosome in linkage disequilibrium (Fig. 1).
CRISPR: A game-changing genetic engineering technique – Science in the News Have you heard? A revolution has seized the scientific community. Within only a few years, research labs worldwide have adopted a new technology that facilitates making specific changes in the DNA of humans, other animals, and plants. Compared to previous techniques for modifying DNA, this new approach is much faster and easier. What is CRISPR CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeat. How does it work? Figure 1 ~ The steps of CRISPR-mediated immunity. Interspersed between the short DNA repeats of bacterial CRISPRs are similarly short variable sequences called spacers (FIGURE 1). The CRISPR immune system works to protect bacteria from repeated viral attack via three basic steps : Step 1) Adaptation – DNA from an invading virus is processed into short segments that are inserted into the CRISPR sequence as new spacers. Step 3) Targeting – CRISPR RNAs guide bacterial molecular machinery to destroy the viral material. In Industry In the Lab In Medicine
TEDxDeExtinction | Revive & Restore The GreatPassenger PigeonComeback Male passenger pigeon, painting by Tim Hough. News & updates on the project using museum-specimen DNA to bring this iconic species all the way back. Extinction Continuum Learn about the genetic situation of a variety of endangered and extinct animals and how biotechnologies might be applied. Criteria Checklist Can a particular extinct species be revived? Never Say Never Extinct heath hen Gazette archives “Heath Hen May Get Its Boom Back” Revive & Restore posed the question of bringing the heath hen back to Martha’s Vineyard. TEDx Videos On March 15, 2013 at National Geographic, twenty-five extraordinary talks by leading scientists and conservationists were captured on video on the concept of de-extinction. Watch TEDxDeExtinction Videos Stewart Brand’s TED Talk Throughout humankind’s history, we’ve driven species after species extinct… But now, says Stewart Brand, we have the technology to bring back species that humanity wiped out. Become a Supporter
Biologie moléculaire Génie-génétique et biotechnologies Schémas bilan Bibliographie CAMPBELL N. A. – Biologie. Netographie