background preloader

THC Gives Cancer Cells the Munchies Too : The Scientific Activist

THC Gives Cancer Cells the Munchies Too : The Scientific Activist
Through the results of widespread experimentation of the… well… let’s say “non-scientific” variety, it’s pretty well known that marijuana has the side effect of making the user very hungry. This is one of the many physiological effects of the active ingredient THC (?9-tetrahydrocannabinol). More relevantly, however, THC and other cannabinoids are actively being investigated for various useful clinical purposes, including the treatment of cancer through the inhibition of tumor growth. A new study by Salazar et al. in The Journal of Clinical Investigation demonstrates that THC causes tumor cells to begin to degrade themselves from the inside (a process called autophagy, i.e. Despite the imagery that the title of this post (and maybe even casual experience) may imply, it’s not that THC causes cancer cells to ravenously and indiscriminately destroy themselves. Mostly, this is interesting (to me) more for the big picture aspect and the implications for clinical medicine. Related:  Medical Cannabis Review

Weed sequenced. No really — weed. (Credit: stock image) DNA sequencing hit a new high with the release of the Cannabis sativa genome, says Nature News. The raw sequence, done in Amsterdam (where else?), was posted on Amazon’s EC2 public cloud computing service by a young company called Medicinal Genomics, which aims to explore the genomes of therapeutic plants. Medicinal Genomics founder Kevin McKernan says he estimates the size of the C. sativa genome to be about 400 million bases. “Ongoing scientific research suggests that the Cannabis plant harbors beneficial compounds as it pertains to cancer apoptosis, antiemesis for HIV and chemotherapy patients, reduction of muscle spasms for multiple sclerosis patients, as well as the treatment of glaucoma, inflammatory diseases, anxiety, and post-traumatic stress disorder, among other health conditions,” according to a statement by the company. “Of the 85 identified Cannabinoids in the plant, only one is independently psychoactive.

Nugshots - Professional Medical Marijuana Photography and Design New drug shrinks cancer in animals, U-M study shows Public release date: 6-Apr-2011 [ Print | E-mail Share ] [ Close Window ] Contact: Nicole Fawcettnfawcett@umich.edu 734-764-2220University of Michigan Health System ANN ARBOR, Mich. — A study led by researchers at the University of Michigan Comprehensive Cancer Center showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects. The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. "For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, Ph.D., Warner-Lambert/Parke-Davis Professor in Medicine and director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center. Wang presented the study at the American Association for Cancer Research 102nd annual meeting. [ Print | E-mail AAAS and EurekAlert!

What cannabis actually does to your brain Chances are they would've ended up brainless morons with or without the pot. It's quite frankly not strong enough of a narcotic to destroy one's life such as you describe. It's very dependent on the user's persona. @Tadashii: Are you also for alcohol and tobacco prohibition? Wow- Tadashii, pot is not meth or cocaine. Yes, its a chemical that can intoxicate and has been embraced by, and been the cause of some lazy folks, underachievers, and Grateful Dead fans not amounting to much. Pot is like anything else- tobacco, alcohol, vicodin, valium, caffeine, etc. Cannabis has great promise for any treatment that requires appetite stimulant (such as cancer, HIV, etc), and has also been found to act as an anti-inflammatory or nausea reliever, Don't just stamp marijuana "evil". Do you enjoy any caffeinated sodas, cigarettes, or the occasional alcoholic beverage? Yes I am against alcohol too and I agree that it's worse than pot.

Molecular mechanism found that controls marijuana-like substance in body | KurzweilAI - (Build 20100722150226) A newly discovered molecular mechanism helps control the amount and effectiveness of a substance that mimics an active ingredient in marijuana, but that is produced by the body’s own nerve cells. The results were reported in the latest Nature Neuroscience. The lead author on the study is William R. In previous papers, Stella and other scientists have noted that the body manufactures several cell signals called endocannabinoids that mimic the actions of marijuana-derived chemicals. Because cannabinoid signaling systems are common throughout the body and affect a variety of functions, therapies aimed at these systems might be more wide-ranging than simply a better substitute for medicinal marijuana. Controlling cannabinoid receptors to control pain, anxiety, and brain inflammation Earlier Stella’s group discovered a key endocannabinoid, called 2-AG, that carries a type of messaging between brain cells. 2-AG is also implicated in brain cell migration and brain tissue inflammation.

'Good cholesterol' nanoparticles seek and destroy cancer cells Public release date: 1-Apr-2011 [ Print | E-mail Share ] [ Close Window ] Contact: Scott Mervillesmerville@mdanderson.org 713-792-0661University of Texas M. HOUSTON - High-density lipoprotein's hauls excess cholesterol to the liver for disposal, but new research suggests "good cholesterol" can also act as a special delivery vehicle of destruction for cancer. Synthetic HDL nanoparticles loaded with small interfering RNA to silence cancer-promoting genes selectively shrunk or destroyed ovarian cancer tumors in mice, a research team led by scientists from The University of Texas MD Anderson Cancer Center and the University of North Texas Health Science Center reports in the April edition of Neoplasia. "RNA interference has great therapeutic potential but delivering it to cancer cells has been problematic," said Anil Sood, M.D., the study's senior author and MD Anderson's director of Ovarian Cancer Research and co-director of the Center for RNA Interference and Non-Coding RNA at MD Anderson.

Israeli company grows medical marijuana which doesn't get you high Situated in an undisclosed location near Tzfat, northern Israel, is a government-approved medical marijuana plantation which was founded in 2004 by a retired biology teacher. Named Tikun Olam, the plantation has created a new cannabis strain which contains very low traces of tetrahydrocannabinol (THC), the main constituent in cannabis responsible for making people feel "stoned". By virtually eliminating THC in the new strain, Tikun Olam can now offer the drug's medicinal benefits to those patients who wish to keep a clear head. Marijuana contains over 60 constituents named cannabinoids and though THC is the most famous due to its psychoactive effects, another important constituent is cannabidiol (CBD). The new strain of marijuana created at Tikun Olam does just that. The promotional video below sheds more light on the Tikun Olam plantation. Source: Tikun-Olam , via: Reuters

Formaldehyde Is Added to List of Carcinogens + (Aspartame Lupus claim) The government issued warnings on Friday about two materials used daily by millions of Americans, saying that one causes cancer and the other might.Government scientists listed formaldehyde as a carcinogen, and said it is found in worrisome quantities in plywood, particle board, mortuaries and hair salons. They also said that styrene, which is used in boats, bathtubs and in disposable foam plastic cups and plates, may cause cancer but is generally found in such low levels in consumer products that risks are low.Frequent and intense exposures in manufacturing plants are far more worrisome than the intermittent contact that most consumers have, but government scientists said that consumers should still avoid contact with formaldehyde and styrene along with six other chemicals that were added Friday to the government’s official Report on Carcinogens. Like this: Like Loading...

How to Open a Medical Marijuana Dispensary? Ask Stewart Richlin

Related: