Methylhexanamine Chemical compound Methylhexanamine (also known as methylhexamine, 1,3-dimethylamylamine, 1,3-DMAA, dimethylamylamine, and DMAA; trade names Forthane and Geranamine) is an indirect sympathomimetic drug invented and developed by Eli Lilly and Company and marketed as an inhaled nasal decongestant from 1948 until it was voluntarily withdrawn from the market in the 1980s.[2] Since 2006 methylhexanamine has been sold extensively under many names as a stimulant or energy-boosting dietary supplement under the claim that it is similar to certain compounds found in geraniums, but its safety has been questioned as a number of adverse events and at least five deaths have been associated with methylhexanamine-containing supplements.[3] It is banned by many sports authorities and governmental agencies. History[edit] Marketing as dietary supplement[edit] Patrick Arnold reintroduced methylhexanamine in 2006 as a dietary supplement,[7][8] after the final ban of ephedrine in the United States in 2005.
The Good Drug Guide : new mood-brighteners and antidepressants Methcathinone Psychoactive stimulant Methcathinone (α-methylamino-propiophenone or ephedrone) (sometimes called "cat" or "jeff" or "catnip" or "M-Kat" or "kat" or "intash" ) is a monoamine alkaloid and psychoactive stimulant, a substituted cathinone. It is used as a recreational drug due to its potent stimulant and euphoric effects and is considered to be addictive, with both physical and psychological withdrawal occurring if its use is discontinued after prolonged or high-dosage administration.[1] It is usually snorted, but can be smoked, injected, or taken orally. Methcathinone is listed as a Schedule I controlled substance by the Convention on Psychotropic Substances and the United States' Controlled Substances Act, and as such it is not considered to be safe or effective in the treatment, diagnosis, prevention, or cure of any disease, and has no approved medical use. History[edit] Chemistry[edit] Methcathinone possesses a chiral carbon atom, and therefore two enantiomers are possible. Effects[edit]
Mephedrone Synthetic stimulant drug Mephedrone, also known as 4-methylmethcathinone, 4-MMC, and 4-methylephedrone, is a synthetic stimulant drug of the amphetamine and cathinone classes. Slang names include drone,[3] M-CAT,[4] White Magic,[5] and meow meow.[6] It is chemically similar to the cathinone compounds found in the khat plant of eastern Africa.[3][7] It comes in the form of tablets or crystals,[8] which users can swallow, snort or inject, producing effects similar to those of MDMA, amphetamines and cocaine. In addition to its stimulant effects, mephedrone produces side effects, of which bruxism is the most common. Mephedrone was first synthesised in 1929, but did not become widely known until it was rediscovered in 1999–2000 at which point it was legal to produce and possess in many countries. Uses[edit] Recreational[edit] Available forms[edit] Purity[edit] Adverse effects[edit] Short-term effects[edit] Neurotoxicity[edit] Reinforcement disorders[edit] Overdose[edit] Toxicity[edit] Deaths[edit]
The Creative Process and Entheogens by Alex Grey The Creative Process and Entheogens by Alex Grey adapted from The Mission of Art PDF version of this document Twenty-five years ago I took my first dose of LSD. The experience was so rich and profound, coupled as it was with the meeting of my future wife, Allyson, that there seemed nothing more important than this revelation of infinite love and unity. Being an artist, I felt that this was the only subject worthy of my time and attention. Due to its visionary richness, I think the entheogenic experience has great importance for fueling an artistic and cultural renaissance. Oscar Janiger's studies of LSD and creativity showed that many artists felt the work done while tripping or post-tripping was more inventive and inspired work than their previous work. "How can we bring the insights of the entheogenic state into our lives?" First Effects: 1). Beginning to Surrender to a Higher Power: 3). Transpersonal Stages: 4). The Creative Process: 1). Notes: 1.
Methoxetamine Dissociative drug Methoxetamine, abbreviated as MXE, is a dissociative hallucinogen that has been sold as a designer drug.[3][4] It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in that it was designed specifically for recreational use.[4][5] Due to its structural similarity to ketamine, it is no longer produced in sizeable quantities due to near-global bans. It is a rare example of a drug being so widely controlled without having an existing medical use. MXE is an arylcyclohexylamine.[6] It acts mainly as an NMDA receptor antagonist, similarly to other arylcyclohexylamines like ketamine and PCP.[6] Recreational use[edit] Effects[edit] Pharmacology[edit] Pharmacodynamics[edit] Pharmacokinetics[edit] MXE has a longer duration of action than that of ketamine.[17] Chemistry[edit] Methoxetamine and related arylcyclohexylamines. MXE hydrochloride is soluble in ethanol up to 10 mg/ml at 25 °C.[18] Utah
p-Hydroxynorephedrine p-Hydroxynorephedrine (PHN), or 4-hydroxynorephedrine, is the para-hydroxy analog of norephedrine and an active sympathomimetic metabolite of amphetamine in humans.[1][2] When it occurs as a metabolite of amphetamine, it is produced from both p-hydroxyamphetamine and norephedrine.[2][3][4] [edit] Notes[edit] ^ 4-Hydroxyamphetamine has been shown to be metabolized into 4-hydroxynorephedrine by dopamine beta-hydroxylase (DBH) in vitro and it is presumed to be metabolized similarly in vivo.[6][11] Evidence from studies that measured the effect of serum DBH concentrations on 4-hydroxyamphetamine metabolism in humans suggests that a different enzyme may mediate the conversion of 4-hydroxyamphetamine to 4-hydroxynorephedrine;[11][13] however, other evidence from animal studies suggests that this reaction is catalyzed by DBH in synaptic vesicles within noradrenergic neurons in the brain.[14][15] See also[edit] Hydroxynorephedrine References[edit] References[edit] External links[edit]
History of LSD The psychedelic drug (or entheogen) lysergic acid diethylamide (LSD) was first synthesized on November 16, 1938 by the Swiss chemist Albert Hofmann in the Sandoz (now Novartis) laboratories in Basel, Switzerland.[1] It was not until five years later on April 19, 1943, that the psychedelic properties were found.[2] Discovery[edit] Albert Hofmann, born in Cyprus, joined the pharmaceutical-chemical department of Sandoz Laboratories, located in Basel as a co-worker with professor Arthur Stoll, founder and director of the pharmaceutical department.[3] He began studying the medicinal plant squill and the fungus ergot as part of a program to purify and synthesize active constituents for use as pharmaceuticals. ... affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination. "Bicycle Day"[edit] Bicycle Day Celebration Blotter Psychiatric use[edit] R. Dr.
Methadone Opioid medication used for pain; also to treat dependency on opioids Methadone, sold under the brand names Dolophine and Methadose among others, is a synthetic opioid agonist used for chronic pain and also for opioid dependence.[5] It is used to treat chronic pain, and it is also used to treat addiction to heroin or other opioids.[8][9] Prescribed for daily use, the medicine relieves cravings and removes withdrawal symptoms.[10] Detoxification using methadone can be accomplished in less than a month, or it may be done gradually over as long as six months.[5] While a single dose has a rapid effect, maximum effect can take up to five days of use.[5] The pain-relieving effects last about six hours after a single dose.[5][11] After long-term use, in people with normal liver function, effects last 8 to 36 hours.[5][7] Methadone is usually taken by mouth and rarely by injection into a muscle or vein.[5] Medical uses[edit] Opioid addiction[edit] Pain[edit] Adverse effects[edit] Physical symptoms
4-Hydroxyamphetamine Group of stereoisomers 4-Hydroxyamphetamine (4HA), also known as hydroxyamfetamine, hydroxyamphetamine, oxamphetamine, norpholedrine, para-hydroxyamphetamine, and α-methyltyramine, is a drug that stimulates the sympathetic nervous system. It is used medically in eye drops to dilate the pupil (a process called mydriasis), so that the back of the eye can be examined. It is also a major metabolite of amphetamine and certain substituted amphetamines. Medical use[edit] 4-Hydroxyamphetamine is used in eye drops to dilate the pupil (a process called mydriasis) so that the back of the eye can be examined. 4-hydroxyamphetamine has some limitations to its use as a diagnostic tool. Pharmacology[edit] Like amphetamine, 4-hydroxyamphetamine is an agonist of human TAAR1.[4] 4-Hydroxyamphetamine acts as an indirect sympathomimetic and causes the release of norepinephrine from nerve synapses which leads to mydriasis (pupil dilation).[3][5] Commercialization[edit] See also[edit] Notes[edit] References[edit]
5-Methoxymethylone Chemical compound of the cathinone class Legal Status[edit] 5-Methoxymethylone is listed as an illegal drug under the name 2-A1MP in Hungary.[5] See also[edit] References[edit] Ethylnorepinephrine From Wikipedia, the free encyclopedia Chemical compound Ethylnorepinephrine (Etanor, Bronkephrine, Butanefrine) is a sympathomimetic and bronchodilator related to norepinephrine.[1][2][3] It activates both α and β adrenergic receptors.[4] See also[edit] Norepinephrine References[edit] MDMA MDMA (3,4-methylenedioxy-N-methylamphetamine) is an empathogenic drug of the phenethylamine and amphetamine classes of drugs. MDMA has become widely known as "ecstasy" (shortened to "E", "X", or "XTC"), usually referring to its street form, although this term may also include the presence of possible adulterants. The UK term "Mandy" and the US term "Molly" colloquially refer to MDMA that is relatively free of adulterants.[3] MDMA can induce euphoria, a sense of intimacy with others, diminished anxiety, and mild psychedelia. Many studies, particularly in the fields of psychology and cognitive therapy, have suggested MDMA has therapeutic benefits and facilitates therapy sessions in certain individuals, a practice for which it had been formally used in the past. Clinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder, anxiety associated with terminal cancer[4][5] and addiction.[6] Medical use[edit] Recreational use[edit] Tablets containing MDMA