The Good Drug Guide : new mood-brighteners and antidepressants Methcathinone Psychoactive stimulant Methcathinone (α-methylamino-propiophenone or ephedrone) (sometimes called "cat" or "jeff" or "catnip" or "M-Kat" or "kat" or "intash" ) is a monoamine alkaloid and psychoactive stimulant, a substituted cathinone. It is used as a recreational drug due to its potent stimulant and euphoric effects and is considered to be addictive, with both physical and psychological withdrawal occurring if its use is discontinued after prolonged or high-dosage administration.[1] It is usually snorted, but can be smoked, injected, or taken orally. Methcathinone is listed as a Schedule I controlled substance by the Convention on Psychotropic Substances and the United States' Controlled Substances Act, and as such it is not considered to be safe or effective in the treatment, diagnosis, prevention, or cure of any disease, and has no approved medical use. History[edit] Chemistry[edit] Methcathinone possesses a chiral carbon atom, and therefore two enantiomers are possible. Effects[edit]
The Creative Process and Entheogens by Alex Grey The Creative Process and Entheogens by Alex Grey adapted from The Mission of Art PDF version of this document Twenty-five years ago I took my first dose of LSD. The experience was so rich and profound, coupled as it was with the meeting of my future wife, Allyson, that there seemed nothing more important than this revelation of infinite love and unity. Being an artist, I felt that this was the only subject worthy of my time and attention. Due to its visionary richness, I think the entheogenic experience has great importance for fueling an artistic and cultural renaissance. Oscar Janiger's studies of LSD and creativity showed that many artists felt the work done while tripping or post-tripping was more inventive and inspired work than their previous work. "How can we bring the insights of the entheogenic state into our lives?" First Effects: 1). Beginning to Surrender to a Higher Power: 3). Transpersonal Stages: 4). The Creative Process: 1). Notes: 1.
Methoxetamine Dissociative drug Methoxetamine, abbreviated as MXE, is a dissociative hallucinogen that has been sold as a designer drug.[3][4] It differs from many dissociatives such as ketamine and phencyclidine (PCP) that were developed as pharmaceutical drugs for use as general anesthetics in that it was designed specifically for recreational use.[4][5] Due to its structural similarity to ketamine, it is no longer produced in sizeable quantities due to near-global bans. It is a rare example of a drug being so widely controlled without having an existing medical use. MXE is an arylcyclohexylamine.[6] It acts mainly as an NMDA receptor antagonist, similarly to other arylcyclohexylamines like ketamine and PCP.[6] Recreational use[edit] Effects[edit] Pharmacology[edit] Pharmacodynamics[edit] Pharmacokinetics[edit] MXE has a longer duration of action than that of ketamine.[17] Chemistry[edit] Methoxetamine and related arylcyclohexylamines. MXE hydrochloride is soluble in ethanol up to 10 mg/ml at 25 °C.[18] Utah
History of LSD The psychedelic drug (or entheogen) lysergic acid diethylamide (LSD) was first synthesized on November 16, 1938 by the Swiss chemist Albert Hofmann in the Sandoz (now Novartis) laboratories in Basel, Switzerland.[1] It was not until five years later on April 19, 1943, that the psychedelic properties were found.[2] Discovery[edit] Albert Hofmann, born in Cyprus, joined the pharmaceutical-chemical department of Sandoz Laboratories, located in Basel as a co-worker with professor Arthur Stoll, founder and director of the pharmaceutical department.[3] He began studying the medicinal plant squill and the fungus ergot as part of a program to purify and synthesize active constituents for use as pharmaceuticals. ... affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination. "Bicycle Day"[edit] Bicycle Day Celebration Blotter Psychiatric use[edit] R. Dr.
Methadone Opioid medication used for pain; also to treat dependency on opioids Methadone, sold under the brand names Dolophine and Methadose among others, is a synthetic opioid agonist used for chronic pain and also for opioid dependence.[5] It is used to treat chronic pain, and it is also used to treat addiction to heroin or other opioids.[8][9] Prescribed for daily use, the medicine relieves cravings and removes withdrawal symptoms.[10] Detoxification using methadone can be accomplished in less than a month, or it may be done gradually over as long as six months.[5] While a single dose has a rapid effect, maximum effect can take up to five days of use.[5] The pain-relieving effects last about six hours after a single dose.[5][11] After long-term use, in people with normal liver function, effects last 8 to 36 hours.[5][7] Methadone is usually taken by mouth and rarely by injection into a muscle or vein.[5] Medical uses[edit] Opioid addiction[edit] Pain[edit] Adverse effects[edit] Physical symptoms
5-Methoxymethylone Chemical compound of the cathinone class Legal Status[edit] 5-Methoxymethylone is listed as an illegal drug under the name 2-A1MP in Hungary.[5] See also[edit] References[edit] MDMA MDMA (3,4-methylenedioxy-N-methylamphetamine) is an empathogenic drug of the phenethylamine and amphetamine classes of drugs. MDMA has become widely known as "ecstasy" (shortened to "E", "X", or "XTC"), usually referring to its street form, although this term may also include the presence of possible adulterants. The UK term "Mandy" and the US term "Molly" colloquially refer to MDMA that is relatively free of adulterants.[3] MDMA can induce euphoria, a sense of intimacy with others, diminished anxiety, and mild psychedelia. Many studies, particularly in the fields of psychology and cognitive therapy, have suggested MDMA has therapeutic benefits and facilitates therapy sessions in certain individuals, a practice for which it had been formally used in the past. Clinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder, anxiety associated with terminal cancer[4][5] and addiction.[6] Medical use[edit] Recreational use[edit] Tablets containing MDMA
4-Methylaminorex Group of stereoisomers 4-Methylaminorex (4-MAR, 4-MAX) is a stimulant drug of the 2-amino-5-aryloxazoline class that was first synthesized in 1960 by McNeil Laboratories.[1] It is also known by its street names "U4Euh" ("Euphoria") and "Ice". It is banned in many countries as a stimulant. 4-Methylaminorex has effects comparable to methamphetamine but with a longer duration. The results of animal experiments conducted with this drug suggest that it has an abuse liability similar to cocaine and amphetamine. Chemistry[edit] 4-Methylaminorex exists as four stereoisomers : (±)-cis and (±)-trans. Dosage[edit] There is a patent about the use of 4-methylaminorex "as a nasal decongestant which, when administered orally, does not produce adverse central nervous system stimulant effects as experienced with other decongestants and anorexiants." Effects[edit] There has been one reported death due to 4-methylaminorex and diazepam. Neurotoxicity studies[edit] References[edit] External links[edit]
List of fentanyl analogues This is a list of fentanyl analogues (sometimes referred to as Fentalogs),[1][2][3] including both compounds developed by pharmaceutical companies for legitimate medical use, and those which have been sold as designer drugs and reported to national drug control agencies such as the DEA, or transnational agencies such as the EMCDDA and UNODC.[4][5][6][7][8][9] This is not a comprehensive listing of fentanyl analogues, as more than 1400 compounds from this family have been described in the scientific and patent literature,[10][11][12][13][14] but it includes all notable compounds that have reached late-stage human clinical trials, or which have been identified as having been sold as designer drugs, as well as representative examples of significant structural variations reported in the scientific and patent literature. Chemical structures of various fentanyl analogues[edit] Analogue controls[edit] (a) an acetyl, propionyl, butenoyl or butanoyl radical, attached to the aniline nitrogen atom:
3,4-Methylenedioxyamphetamine Empathogen-entactogen, psychostimulant, and psychedelic drug of the amphetamine family 3,4-Methylenedioxyamphetamine (also known as MDA and sass) is an empathogen-entactogen, psychostimulant, and psychedelic drug of the amphetamine family that is encountered mainly as a recreational drug. In its pharmacology, MDA is a serotonin–norepinephrine–dopamine releasing agent (SNDRA). In most countries, the drug is a controlled substance and its possession and sale are illegal. MDA is rarely sought as a recreational drug compared to other amphetamines; however, it remains widely used due to it being a primary metabolite,[2] the product of hepatic N-dealkylation,[3] of MDMA (ecstasy). Uses[edit] Medical[edit] MDA currently has no accepted medical use. Recreational[edit] Adverse effects[edit] MDA produces serotonergic neurotoxic effects,[8][9] thought to be activated by initial metabolism of MDA.[3] In addition, MDA activates a response of the neuroglia, though this subsides after use.[8] Overdose[edit]
Lisdexamfetamine CNS stimulant (prodrug) Lisdexamfetamine, sold under the brand name Vyvanse among others, is a stimulant medication that is mainly used to treat attention deficit hyperactivity disorder (ADHD) in people over the age of five as well as moderate-to-severe binge eating disorder in adults.[11] Lisdexamfetamine is taken by mouth. Its effects generally begin within 2 hours and last for up to 14 hours.[11][12] In the United Kingdom, it is usually less preferred than methylphenidate for the treatment of children.[13] Lisdexamfetamine is an inactive prodrug that works after being converted by the body into dextroamphetamine, a central nervous system (CNS) stimulant.[11][15] Chemically, lisdexamfetamine is composed of the amino acid L-lysine, attached to dextroamphetamine.[16] Uses[edit] Medical[edit] Part of this section is transcluded from amphetamine. Enhancing performance[edit] Cognitive performance[edit] Physical performance[edit] Available forms[edit] Contraindications[edit] Adverse effects[edit]
3,4-Methylenedioxy-N-ethylamphetamine From Wikipedia, the free encyclopedia Chemical compound 3,4-Methylenedioxy-N-ethylamphetamine (MDEA; also called MDE and colloquially, Eve) is an empathogenic psychoactive drug. MDEA is a substituted amphetamine and a substituted methylenedioxyphenethylamine. MDEA acts as a serotonin, norepinephrine, and dopamine releasing agent and reuptake inhibitor.[1] Possession of MDEA is illegal in most countries. Uses[edit] Medical[edit] MDEA currently has no accepted medical uses. Recreational[edit] Adverse effects[edit] Reported adverse effects from MDEA include the following: Overdose[edit] Reported overdose symptoms of MDEA include the following: Chemistry[edit] Synthesis[edit] MDEA is typically synthesized from essential oils such as safrole or piperonal. History, society, and culture[edit] Alexander Shulgin conducted research on methylenedioxy compounds in the 1960s. See also[edit] References[edit]