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Genome Research

Genome Research
Related:  Integrative Medicine

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PRKRA Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or Protein ACTivator of the interferon-induced protein kinase (PACT) is a protein that in humans is encoded by the PRKRA gene.[1][2][3] PACT heterodimerizes with and activates protein kinase R.[2][4] PRKRA mutations have been linked to a rare form of dystonia parkinsonism. [5] References[edit] Further reading[edit]

Birth and expression evolution of mammalian microRNA genes + Author Affiliations + Author Notes ↵Present addresses: 4GenoSplice technology, 75010 Paris, France; ↵5 Harvard Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA; ↵6 Broad Institute, Cambridge, Massachusetts 02142, USA. Abstract MicroRNAs (miRNAs) are major post-transcriptional regulators of gene expression, yet their origins and functional evolution in mammals remain little understood due to the lack of appropriate comparative data.

Systems Biology Markup Language Human Givens Institute: Holistic & Scientific Approach To Your Needs Human Phenotype Ontology Website - The Human Phenotype Ontology Popular press wildly overblows “gene for humanity” I’m about to describe one of the worst examples of science journalism I’ve seen in ages. It is a lesson on how the popular press overblows interesting scientific findings into world-shaking discoveries. miRNAs, or “microRNAs”, are small molecules of RNA, produced by the DNA, that have recently been discovered to play an important role in gene regulation, usually by binding to a “regulatory portion” of a gene and silencing that gene (i.e., preventing its expression). A new paper in Nature Communications by Hai Yang Hu and others (some of them from the University of Edinburgh) report a new miRNA that is specific to the human lineage: it’s not present in our closest relative, chimpanzees, or in 10 other species. And indeed they did find one, which is what their report is about. First, what did Hu et al. find? MicroRNA-mediated gene regulation is important in many physiological processes. True, but as the authors note, that “microdeleted region” contains a lot more genes than just miR-941:

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