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Full article: The gut microbiota as a target to control hyperuricemia pathogenesis: Potential mechanisms and therapeutic strategies

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2020 American College of Rheumatology Guideline for the Management of Gout - FitzGerald - 2020 - Arthritis Care & Research Methods This guideline follows the ACR guideline development process ( using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology to rate the certainty of evidence and develop recommendations 15-17, with an emphasis on developing actionable guidelines. ACR policy guided the management of conflicts of interest and disclosures ( A full description of the methods is presented in Supplementary Appendix 1 (available on the Arthritis Care & Research web site at The Core Team prespecified outcomes as critical or important for each PICO question for the systematic literature review. Outcomes varied across PICO topic (for details, see Supplementary Appendix 3, at Gout flare and serum urate (SU) concentration (and tophus for PICO question 1) were specified as critical outcomes for all PICO questions specific to ULT. Pain was identified as critical for PICO questions specific to gout flare.

Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis Fibromyalgia syndrome (FMS) is characterised by chronic widespread pain alongside fatigue, poor sleep quality and numerous comorbidities. It is estimated to have a worldwide prevalence of 1.78%, with a predominance in females. Treatment interventions for fibromyalgia have limited success, leading to many patients seeking alternative forms of treatment, including modifications to their diet and lifestyle. The effectiveness of dietary changes in fibromyalgia has not been widely researched or evaluated.

11 Simple Ways to Improve Your Memory Whether you want to be a Jeopardy! champion or just need to remember where you parked your car, here are 11 things you can do right now to turn your mind from a sieve into a steel trap. These days we’re all about things being faster. That’s why this advice is invaluable: When you really need to remember something, concentrate on it for at least 8 seconds. Economic Impact of Implementing Malnutrition Screening and Nutritional Management in Older Adults in General Practice This service evaluation demonstrates practically the positive impact of following the Malnutrition Pathway for patients at risk of malnutrition in primary care, over a short period of time. It highlights the importance of screening and appropriate management which includes using oral nutrition support and reviewing patients against goals. It highlights the greatest impact for both the patient and healthcare economy is in the management of those at HR, who received DA and high protein ready to drink ONS. Overall patients at HR achieved the greatest reductions in hospital admissions, length of stay, GP contacts, and antibiotic prescriptions, all of which were significantly reduced. Alongside the economic benefits, malnutrition risk was reduced and patients reported being highly satisfied with the interventions (DA and ONS), and had excellent compliance to ONS. The reason for the greatest benefit in the HR group may be linked to them receiving a combined approach to nutrition support.

Genetic and Physiological Factors Affecting Human Milk Production and Composition HMOs, a structurally complex and diverse group of glycans, represent the third most abundant component in human milk right after lactose and lipids (excluding water) [115]. HMOs are thought to participate in numerous functions including metabolism, probiotic and prebiotic, antimicrobial, modulation of infant intestinal epithelial cell responses, immune response, nutritional effects, as well as brain development [70,115,116,117,118,119]. Like blood groups, the composition of HMOs depends on the expression of certain glycosyltransferases. Benefits of Probiotics in Rheumatic Diseases Rheumatic diseases are chronic conditions which affect a large proportion of the population worldwide (1). Among them, inflammatory chronic diseases including rheumatoid arthritis (RA), spondyloarthritis (SpA), crystal-induced arthritis (CIA), and connective tissue autoimmune diseases, such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), are the most common. Chronic inflammation has been recognized to play a role also in osteoarthritis (OA), classically considered a non-inflammatory form of arthritis. Although different risk factors influence their onset and development, these heterogeneous conditions share common clinical outcome including joint pain, disability, and comorbidities (2). Over the last years increasing attention have been paid to the role of diet in the pathogenesis and progression of rheumatic diseases.

Dietary Patterns and Interventions to Alleviate Chronic Pain Pain is one of the main problems for modern society and medicine, being the most common symptom described by almost all patients. When pain becomes chronic, the life of the patients is dramatically affected, being associated with significant emotional distress and/or functional disability. A complex biopsychosocial evaluation is necessary to better understand chronic pain, where good results can be obtained through interconnected biological, psychological, and social factors. The aim of this study was to find the most relevant articles existent in the PubMed database, one of the most comprehensive databases for medical literature, comprising dietary patterns to alleviate chronic pain.

The Two Minutes It Takes To Read This Will Improve Your Writing Forever – For The Interested You’re busy, so I’ll keep this quick. Following are the simplest tips I can give you to easily — and forever — improve the quality of your writing. Delete the word “that.” At least 90% of the times you use the word “that” can be removed from your writing and it will instantly make your sentence stronger. Example: “You believe that I’m lying, but I’m not.” becomes “You believe I’m lying, but I’m not.”

The World Health Organization (WHO) approach to healthy ageing - Maturitas Highlights •The ageing global population is the important medical and social demographic problem.•WHO underlines the importance of maintaining functional ability in older age.•WHO identified strategic objectives and priorities to promote healthy ageing.•Person-oriented long-term integrated care is the key issue. Barriers to Breastfeeding: Supporting Initiation and Continuation of Breastfeeding Number 821 (Replaces Committee Opinion 570, August 2013) Committee on Health Care for Underserved Women Breastfeeding Expert Work Group This Committee Opinion was developed by the American College of Obstetricians and Gynecologists’ Committee on Health Care for Underserved Women and the Breastfeeding Expert Work Group in collaboration with committee member Caroline E. Rouse, MD, and work group member Lauren E. Hanley, MD, IBCLC.

Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts Abstract Objective To systematically test dietary components for association with serum urate levels and to evaluate the relative contributions of estimates of diet pattern and inherited genetic variants to population variance in serum urate levels. Design Meta-analysis of cross sectional data from the United States.

Nutritional Interventions in the Management of Fibromyalgia Syndrome Fibromyalgia (FM) is a multifactorial syndrome of unknown etiology, characterized by widespread chronic pain and various somatic and psychological manifestations. The management of FM requires a multidisciplinary approach combining both pharmacological and nonpharmacological strategies. Among nonpharmacological strategies, growing evidence suggests a potential beneficial role for nutrition. This review summarizes the possible relationship between FM and nutrition, exploring the available evidence on the effect of dietary supplements and dietary interventions in these patients. Analysis of the literature has shown that the role of dietary supplements remains controversial, although clinical trials with vitamin D, magnesium, iron and probiotics’ supplementation show promising results.

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