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Healthy Food, Eating, and Nutrition Cannabis eases multiple sclerosis (MS) stiffness per study published in neurology journal Yellowj/Shuttertsock.com Use of cannabis extract helps ease painful muscle stiffness among patients with multiple sclerosis (MS), according to a large trial published on Tuesday in the Journal of Neurology, Neurosurgery and Psychiatry. The "Phase III" test -- the final stage in a process to vet a new drug or medical process -- took place among 22 centres in Britain. Over 12 weeks, 144 patients were given daily tablets of tetrahydrocannabinol, which is the active ingredient in cannabis, and 135 were given a dummy pill, also called a placebo. Doses were gradually escalated, from 2.5 milligrams to a maximum of 25 mg for two weeks, following top-up doses for the remaining two weeks. At the end of the study, 29.4 percent of people in the cannabis group said they had experienced relief from muscle spasms, compared to 15.7 percent in the placebo group, according to an 11-point rating. They also reported improvement in sleep quality.