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Science-Based Medicine – Exploring issues and controversies in the relationship between science and medicine

Science-Based Medicine – Exploring issues and controversies in the relationship between science and medicine

https://sciencebasedmedicine.org/

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Hydroxychloroquine and azithromycin for coronavirus study – does not work Because of an awful study from France published on 20 March 2020, Donald Trump and other non-scientists pushed hydroxychloroquine and azithromycin for coronavirus. Of course, this old dinosaur and many others like Orac, who has written several articles about it, found the evidence that hydroxychloroquine, usually with the antibiotic azithromycin, had any effect on COVID-19 was very weak. But a small retrospective study showed hydroxychloroquine and azithromycin had no positive effect on the course or outcomes from severe cases of COVID-19. Let’s take a look.

UW experts on novel coronavirus (COVID-19) The University of Washington is home to many experts on topics related to the COVID-19 pandemic. Expand each topic to see their names and specific expertise. Click on an expert’s name to view their contact information, recent media mentions and more. Public health Click on an expert’s name to view their contact information, recent media mentions and more. Medicine and virology

UW researchers respond to novel coronavirus (COVID-19) COVID-19 experts for reporters US coronavirus predictions are shifting — here’s why Things are still getting worse. The US death toll crossed 14,000 on Wednesday, with a record 1,858 deaths reported just on Tuesday. No, COVID-19 Is Not Like The Flu—And We Have To Stop Comparing Them I don’t know why everyone is freaking out. The flu kills tens of thousands of people each year, and no one is shutting down borders because of that. Sound familiar? Coronavirus mutations and vaccines – worse than murder hornets I am skeptical of the wild claims about getting a COVID-19 vaccine in 12-18 months, and now there is powerful research about coronavirus mutations that makes me very concerned about getting an effective vaccine. And you thought murder hornets were bad? These coronavirus mutations could mean a disaster for current vaccine research – if we’re developing vaccines for a previous strain of COVID-19, rather than more current (and apparently, more virulent) coronavirus vaccines. This makes the murder hornets look like a ladybug. A recent paper looks at a particularly dangerous strain of coronavirus mutations that should make us reassess any optimism about getting a new COVID-19 vaccine.

The Risks - Know Them - Avoid Them It seems many people are breathing some relief, and I’m not sure why. An epidemic curve has a relatively predictable upslope and once the peak is reached, the back slope is also predictable. Assuming we have just crested in deaths at 70k, that would mean that if we stay locked down, we lose another 70,000 people over the next 6 weeks as we come off that peak. That's what's going to happen with a lockdown.

New Immune Cell on the Block During Viral Lung Infections Scientists have identified a novel group of immune cells in the lungs that are associated with the control of inflammation during viral infections, like influenza or possibly coronavirus. This discovery may help to advance the development of therapeutics to treat inflammation-related lung conditions such as bronchitis, influenza and potentially even COVID-19. Macrophages are an important subset of phagocytic immune cells found throughout the body that form part of our body’s first line of defense against invading foreign material, including bacteria and viruses. Alveolar macrophages (AMs) are a well-known inhabitant of the lungs and are responsible for direct clearance of viruses. This new group of immune cells, identified in the lungs of mice, are a distinct group of macrophages, dubbed NAMs (nerve and airway associated macrophages), that appear instead to moderate inflammation in the lungs during viral infection.

Covid-19 death statistics say little about susceptible population Richard A. Goldstein¹, Asif U. Tamuri², David D. Pollock³ ¹Division of Infection and Immunity, University College London; ²Research IT Services, University College London; ³Biochemistry and Molecular Genetics, University of Colorado School of Medicine Our experts are closely following and analyzing updates on this COVID-19 outbreak. Coronaviruses are a family of RNA viruses that typically cause mild respiratory disease in humans. A novel coronavirus (COVID-19) was identified in Wuhan, China in December 2019. Our experts are closely following and analyzing updates on this outbreak. The following resources will be routinely updated.

Understanding global health governance as a complex adaptive system: Global Public Health: Vol 6, No 6 Introduction While it is difficult to point to a specific turning point in the evolution from international health towards global health, the changes that have lead Rosenau (2003, pp. 410–414) to relinquish the use of the term ‘international’ in his conceptualisation of world affairs are evident also within the health sector. The past decade and a half has seen a substantial increase in the numbers of stakeholders in health, and in the configuring of their relationships. Non-Government Organisations (NGOs) have proliferated, particularly at the local level, and bilateral donors have moved from project-based engagement to offer leadership in programmatic and sectoral approaches (Buse and Walt 1997Buse, K. and Walt, G. 1997.

Coronavirus: Research, Commentary, and News The Science journals are striving to provide the best and most timely research, analysis, and news coverage of COVID-19 and the coronavirus that causes it. All content is free to access. News Science's COVID-19 reporting is supported by the Pulitzer Center. “Gradually, then suddenly” — 4 ways to think about Coronavirus The current situation around the coronavirus epidemic is evolving rapidly. In some of my social circles the most pressing worry is, however, not centered on what we ought to be doing to get this under control. For many people the overriding concern is seemingly not to be seen as worried or, God forbid, as “panicking”. From what I can tell this doesn’t derive from a sober analysis of the facts but from some sort of magical thinking which says that bad things haven’t happened here in a long time and therefore surely this cannot be bad. Mental models, like the one just mentioned above, are the things which help us think about the world. That’s why, in situations like these, it may be helpful to examine and challenge our mental models.

COVID-19 Authorities, Contract Vehicles, and Initiatives (a) Micro-purchase threshold. The threshold increases when the head of the agency determines the supplies or services are to be used to facilitate defense against or recovery from cyber, nuclear, biological, chemical, or radiological attack; to facilitate provision of international disaster assistance; or to support response to an emergency or major disaster. (See 2.101) 13 Coronavirus myths busted by science As the novel coronavirus continues to infect people around the world, news articles and social media posts about the outbreak continue to spread online. Unfortunately, this relentless flood of information can make it difficult to separate fact from fiction — and during a viral outbreak, rumors and misinformation can be dangerous. Here at Live Science, we've compiled a list of the most pervasive myths about the novel coronavirus SARS-CoV-2 and COVID-19, the disease it causes, and explained why these rumors are misleading, or just plain wrong. Myth: Face masks can protect you from the virus

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