Amyotrophic lateral sclerosis

Signs and symptoms[edit] The disorder causes muscle weakness and atrophy throughout the body due to the degeneration of the upper and lower motor neurons. Unable to function, the muscles weaken and exhibit atrophy. Individuals affected by the disorder may ultimately lose the ability to initiate and control all voluntary movement, although bladder and bowel sphincters and the muscles responsible for eye movement are usually, but not always, spared until the final stages of the disease.[1] Cognitive function is generally spared for most patients, although some (about 5%) also have frontotemporal dementia.[2] A higher proportion of patients (30–50%) also have more subtle cognitive changes which may go unnoticed, but are revealed by detailed neuropsychological testing. Initial symptoms[edit] The earliest symptoms of ALS are typically obvious weakness and/or muscle atrophy. About 25% of cases are "bulbar onset" ALS. Progression[edit] Late stage[edit] Cause(s)[edit] Genetics[edit] SOD1[edit]

Lou Gehrig Early life[edit] Gehrig was born in the East Harlem neighborhood of Manhattan,[10] weighing almost 14 pounds (6.4 kg) at birth. He was the second child out of four to German immigrants.[11] His father Heinrich was a sheet metal worker by trade, but frequently unemployed due to alcoholism, and his mother Christina was a maid, the main breadwinner and disciplinarian in the family.[12] His two sisters died from whooping cough and measles at an early age; a brother also died in infancy.[13] Young Gehrig helped his mother with her work, doing tasks such as folding laundry and picking up supplies from the local stores.[14] In 1910, Gehrig lived with his parents at 2266 Amsterdam Avenue in Washington Heights.[15] In 1920, the family resided on 8th Avenue in Manhattan.[16] Gehrig first garnered national attention for his baseball ability while playing in a game at Cubs Park (now Wrigley Field) on June 26, 1920. Major League career[edit] New York Yankees (1923-1939)[edit] 1927[edit] 1932[edit]

Fourth of July Events on Long Island 2012 Sunday, July 3 - Riverhead 5:30 p.m. Independence Day celebration on the Peconic Riverfront, Riverhead, NY. Family concert with Who Are Those Guys, followed by Brady Rymer and The Little Band That Could, and rock and roll superstars tribute band, Rock & Roll Review. Saturday, July 6, 2013 - Sag Harbor Fireworks At 9 p.m. in Sag Harbor, fireworks will soar to the sky from a barge. Sunday, July 7, 2013 - Belmont Park - Family Fun Day Bring the whole family to Family Fun Day activities in Belmont's backyard. Saturday, July 13, 2013 - Fireworks on Crescest Beach, Shelter Island If you missed the fireworks on Independence Day, you can still see those vibrant colors light up the sky at Crescent Beach on Shelter Island, NY. Sunday, July 21, 2013 - Huntington Independence Day Huntington Independence Day Reenactment on Huntington Green.This FREE event isn't exactly on the Fourth of July, but it does have relevance to Independence Day. More info: huntingtonmilitia.com.

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