Dimethyltryptamine History Another historical milestone is the discovery of DMT in plants frequently used by Amazonian natives as additive to the vine Banisteriopsis caapi to make ayahuasca decoctions. Biosynthesis Biosynthetic pathway for N,N-dimethyltryptamine This transmethylation mechanism has been repeatedly and consistently proven by radiolabeling of SAM methyl group with carbon-14 (14C-CH3)SAM). Evidence in mammals In 2013, researchers first reported DMT in the pineal gland microdialysate of rodents. A study published in 2014 reported the biosynthesis of N,N-dimethyltryptamine (DMT) in the human melanoma cell line SK-Mel-147 including details on its metabolism by peroxidases.  In a 2014 paper, a group first demonstrated the immunomodulatory potential of DMT and 5-MeO-DMT through the Sigma-1_receptor of human immune cells. INMT Endogenous DMT The first claimed detection of mammalian endogenous DMT was published in June 1965: German researchers F.
Psychonautics Psychonautics (from the Greek ψυχή (psychē "soul/spirit/mind") and ναύτης (naútēs "sailor/navigator")—a sailor of the mind/soul) refers both to a methodology for describing and explaining the subjective effects of altered states of consciousness, including those induced by meditation or mind-altering substances, and to a research paradigm in which the researcher voluntarily immerses himself or herself into an altered mental state in order to explore the accompanying experiences. The term has been applied diversely, to cover all activities by which altered states are induced and utilized for spiritual purposes or the exploration of the human condition, including shamanism, lamas of the Tibetan Buddhist tradition, sensory deprivation, and archaic/modern drug users who use entheogenic substances in order to gain deeper insights and spiritual experiences. A person who uses altered states for such exploration is known as a psychonaut. Etymology and categorization Peter J.
Uttar Pradesh Association of Dead People The Uttar Pradesh Association of Dead People (Uttar Pradesh Mritak Sangh) is a northern Indian pressure group that seeks to reclaim the legal rights of those falsely listed by the Indian government as being dead. In the overcrowded regions of Uttar Pradesh, many have resorted to bribing officials to have the owner of a plot declared deceased and the land transferred to their ownership. The process to undo this is long, arduous, as well as often hopelessly inefficient and corrupt — not to mention that those least able to fight back make excellent victims. The Association seeks to reverse the declarations, call attention to the problem and prevent others from being exploited in similar fashion. The founder and president is Lal Bihari, who was "dead" from 1976 to 1994 and used the word Mritak (Dead) in his name during the period. History Lal Bihari In 1976 15 year old Lal Bihari's application for loan in a bank in Azamgarh was denied. External links
Endocrine system In addition to the specialised endocrine organs mentioned above, many other organs that are part of other body systems, such as bone, kidney, liver, heart and gonads, have secondary endocrine functions. For example the kidney secretes endocrine hormones such as erythropoietin and renin. A number of glands that signal each other in sequence are usually referred to as an axis, for example, the hypothalamic-pituitary-adrenal axis. As opposed to endocrine factors that travel considerably longer distances via the circulatory system, other signaling molecules, such as paracrine factors involved in paracrine signalling diffuse over a relatively short distance. The word endocrine derives from the Greek words ἐνδο- endo- "inside, within," and κρίνειν krinein "to separate, distinguish". Endocrine organs and known secreted hormones Endocrine glands in the human head and neck and their hormones Hypothalamus Pineal body (epiphysis) Pituitary gland (hypophysis) Thyroid Skin
Indole alkaloid History The action of some indole alkaloids has been known for ages. Aztecs used the psilocybin mushrooms which contain alkaloids psilocybin and psilocin. Consumption of rye and related cereals contaminated with the fungus Claviceps purpurea causes ergot poisoning and ergotism in humans and other mammals. The first indole alkaloid, strychnine, was isolated by Pierre Joseph Pelletier and Joseph Bienaimé Caventou in 1818 from the plants of the Strychnos genus. Classification Depending on their biosynthesis, two types of indole alkaloids are distinguished; isoprenoids and non-isoprenoids. Non-isoprenoid: Simple derivatives of indoleSimple derivatives of β-carbolinePyrroloindole alkaloidsIsoprenoid: There are also purely structural classifications based on the presence of carbazole, β-carboline or other units in the carbon skeleton of the alkaloid molecule. Some 200 dimeric indole alkaloids are known with two indole groups. Non-isoprenoid indole alkaloids
Abiogenesis Scientific hypotheses about the origins of life can be divided into a number of categories. Many approaches investigate how self-replicating molecules or their components came into existence. On the assumption that life originated spontaneously on Earth, the Miller–Urey experiment and similar experiments demonstrated that most amino acids, often called "the building blocks of life", can be racemically synthesized in conditions which were intended to be similar to those of the early Earth. Several mechanisms have been investigated, including lightning and radiation. Other approaches ("metabolism first" hypotheses) focus on understanding how catalysis in chemical systems in the early Earth might have provided the precursor molecules necessary for self-replication. Early conditions The Hadean Earth is thought to have had a secondary atmosphere, formed through degassing of the rocks that accumulated from planetesimal impactors. The earliest life on Earth Current models
Melatonin Melatonin The hormone can be used as a sleep aid and in the treatment of sleep disorders. It can be taken orally as capsules, tablets, or liquid. It is also available in a form to be used sublingually, and there are transdermal patches. There have been few clinical trials, particularly long-term ones, in the use of melatonin in humans. Discovery Biosynthesis Melatonin biosynthesis involves four enzymatic steps from the essential dietary amino acid tryptophan, which follows a serotonin pathway. In bacteria, protists, fungi, and plants melatonin is synthesized indirectly with tryptophan as an intermediate product of the shikimic acid pathway. Regulation In vertebrates, melatonin secretion is regulated by norepinephrine. It is principally blue light, around 460 to 480 nm, that suppresses melatonin, proportional to the light intensity and length of exposure. Animals Plants Functions Circadian rhythm Antioxidant Immune system Medical uses
Psilocin Psilocin (also known as 4-OH-DMT, psilocine, psilocyn, or psilotsin), is a substituted tryptamine alkaloid and a serotonergic psychedelic substance. It is present in most psychedelic mushrooms together with its phosphorylated counterpart psilocybin. Psilocin is a Schedule I drug under the Convention on Psychotropic Substances. The mind-altering effects of psilocin are highly variable and subjective and resemble those of LSD and DMT. Chemistry Psilocin and its phosphorylated cousin, psilocybin, were first isolated and named in 1958 by Swiss chemist Albert Hofmann. Psilocin is relatively unstable in solution due to its phenolic hydroxy (-OH) group. Structural analogs Sulphur analogs are known with a benzothienyl replacement as well as 4-SH-DMT. N1-methylpsilocin is a functionally 5-HT2C receptor preferring agonists. 4-fluoro-N,N-dimethyltryptamine is known. O-Acetylpsilocin is an acetylized analog of psilocin, also known as 4-AcO-DMT. Pharmacology
Kaspar Hauser Kaspar Hauser (30 April 1812 (?) – 17 December 1833) was a German youth who claimed to have grown up in the total isolation of a darkened cell. Hauser's claims, and his subsequent death by stabbing, sparked much debate and controversy. Theories propounded at the time linked him with the grand ducal House of Baden. History First appearance There was another short letter enclosed purporting to be from his mother to his prior caretaker. A shoemaker named Weickmann took the boy to the house of Captain von Wessenig, where he would repeat only the words "I want to be a cavalryman, as my father was" and "Horse! He spent the following two months in Vestner Gate Tower (de) in the care of a jailer named Andreas Hiltel. Statue of Kaspar, old city centre, Ansbach, Germany Hauser's story about his life in a dungeon He claimed that he found bread and water next to his bed each morning. This tale aroused great curiosity and made Hauser an object of international attention. Burial
Serotonin Serotonin /ˌsɛrəˈtoʊnɨn/ or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract (GI tract), platelets, and the central nervous system (CNS) of animals, including humans. It is popularly thought to be a contributor to feelings of well-being and happiness. Serotonin secreted from the enterochromaffin cells eventually finds its way out of tissues into the blood. There, it is actively taken up by blood platelets, which store it. When the platelets bind to a clot, they release serotonin, where it serves as a vasoconstrictor and helps to regulate hemostasis and blood clotting. In addition to animals, serotonin is found in fungi and plants. Serotonin's presence in insect venoms and plant spines serves to cause pain, which is a side-effect of serotonin injection. Functions Receptors Gauge of food availability (appetite) Effects of food content 
Psilocybin Psilocybin[nb 1] (/ˌsɪləˈsaɪbɪn/ SIL-ə-SY-bin) is a naturally occurring psychedelic compound produced by more than 200 species of mushrooms, collectively known as psilocybin mushrooms. The most potent are members of the genus Psilocybe, such as P. azurescens, P. semilanceata, and P. cyanescens, but psilocybin has also been isolated from about a dozen other genera. As a prodrug, psilocybin is quickly converted by the body to psilocin, which has mind-altering effects similar (in some aspects) to those of LSD, mescaline, and DMT. In general, the effects include euphoria, visual and mental hallucinations, changes in perception, a distorted sense of time, and spiritual experiences, and can include possible adverse reactions such as nausea and panic attacks. History Early Modern Albert Hofmann (shown here in 1993) purified psilocybin and psilocin from Psilocybe mexicana in the late 1950s. Occurrence
Doctor Sleep (novel) I mentioned two potential projects while I was on the road, one a new Mid-World book (not directly about Roland Deschain, but yes, he and his friend Cuthbert are in it, hunting a skin-man, which are what werewolves are called in that lost kingdom) and a sequel to The Shining called Doctor Sleep. Are you interested in reading either of these? If so, which one turns your dials more? [We] will be counting your votes (and of course it all means nothing if the muse doesn't speak). Voting ended on December 31, 2009, and it was revealed that Doctor Sleep received 5,861 votes, while The Wind Through the Keyhole received 5,812. In an interview with Entertainment Weekly, King revealed that he had hired researcher Rocky Wood to work on the continuity between The Shining and Doctor Sleep. On May 8, 2012, Stephen King's official website announced a tentative publication date of January 15, 2013 for Doctor Sleep.
Conifer cone The male cone (microstrobilus or pollen cone) is structurally similar across all conifers, differing only in small ways (mostly in scale arrangement) from species to species. Extending out from a central axis are microsporophylls (modified leaves). Under each microsporophyll is one or several microsporangia (pollen sacs). The female cone (megastrobilus, seed cone, or ovulate cone) contains ovules which, when fertilized by pollen, become seeds. The female cone structure varies more markedly between the different conifer families, and is often crucial for the identification of many species of conifers. Female cones of the conifer families Pinaceae cones Intact and disintegrated fir cones The members of the pine family (pines, spruces, firs, cedars, larches, etc.) have cones that are imbricate (that is, with scales overlapping each other like fish scales). Araucariaceae cones Podocarpaceae cones Berry-like Podocarpus cone Cupressaceae cones Sciadopityaceae cones
2C-B History 2C-B was synthesized from 2,5-dimethoxybenzaldehyde by Alexander Shulgin in 1974. It first saw use among the psychiatric community as an aid during therapy. Internationally, 2C-B is a Schedule II drug under the Convention on Psychotropic Substances. In the Netherlands, 2C-B became a list I substance of the Opium Law despite no health incidents occurring. Patterns of use 2C-B first became popularized in the United States as a short-lived legal substitute for the street drug Ecstasy when MDMA became illegal in 1985. Many 2C-B users are young adults who attend raves. Though 2C-B is still used in the rave subculture, commonly mistaken for and/or sold as Ecstasy, its intentional use has become more common. In recent years, 2C-B has emerged as the drug of choice for club drug users in Colombia. Street prices range between $10–30 per tablet in the United States when bought in small quantities. Larger retail purchases cost between $200 and $500 per gram.