Diethyltryptamine Chemistry DET is an analogue of the common tryptamine hallucinogen N,N-Dimethyltryptamine or DMT. Pharmacology The mechanism of action is thought to be serotonin receptor agonism, much like other classic psychedelics. DET is sometimes preferred over DMT because it can be taken orally whereas DMT cannot. Biochemistry Though DET is a synthetic compound with no known natural sources it has been used with mycelium of Psilocybe cubensis to produce the synthetic chemicals 4-PO-DET (Ethocybin) and 4-HO-DET (Ethocin), as opposed to the naturally occurring 4-PO-DMT (Psilocybin) and 4-HO-DMT (Psilocin). Psychosis model See also References External links
Modern Shamanism, by Serge Kahili King Article Modern Shamanism by Serge Kahili King "You look more modern than I thought you'd be," said the visitor as we sat in my comfortable living room overlooking the ocean that surrounds the island of Kaua'i. His remark was typical of many visitors who expect - perhaps even hope - to find me wearing some kind of robe or sarong and living in primitive simplicity in a cave or a forest far away from the amenities of civilization. In the old and ancient days the shaman - who was a healer of mind, body and circumstances - was right in the midst of tribal or village life. Now shamanism is experiencing a revival of interest and freedom. A modern shaman (or "urban" shaman, as I often say) is one who uses the ancient knowledge in the context of our present social and cultural environment. Shaman knowledge has to do with an awareness of, and the ability to direct, the powers of mind and the forces of nature. Integration is more difficult in today's society because of its variety and complexity.
Nuciferine References Jump up ^ Bhattacharya SK, Bose R, Ghosh P, Tripathi VJ, Ray AB, Dasgupta B (Sep 1978). "Psychopharmacological studies on (—)-nuciferine and its Hofmann degradation product atherosperminine". Psychopharmacology (Berl.) 59 (1): 29–33. doi:10.1007/BF00428026. See also Ayahuasca Videos | Just another WordPress.com site Psychoactive Vaults : Psychedelic Crisis FAQ This FAQ is not regularly updated or maintained. It may include out-of-date information. Please check the version date to see when it was most recently revised. For current information, see Erowid's summary pages in the substance's main vault. Disclaimer This FAQ is presented for informational purposes only. Credits The information contained in this FAQ has been culled from a variety of sources. Revision History 0.5 - 09/10/97 - Assembled emails and passed around for comment 1.0 - 05/03/98 - Created the basic HTML, FAQ. 1.1 - 11/07/98 - Added index, disclaimer, credits, and significantly improved organization. 1.2 - 12/18/99 - Updated Antidotes section. 2.0 - 08/22/01 - Reorganized from a realtime usage perspective, added Assessment section 2.1 - 08/01/05 - Changed reference to CPR/Rescue Breathing in "Critical or Life Threatening Situation" section 2.2 - 02/17/14 - Added Tripsit link Introduction Assessment Type of Situation Is there immediate or potential physical danger? Quick List Summary
Indole alkaloid History The action of some indole alkaloids has been known for ages. Aztecs used the psilocybin mushrooms which contain alkaloids psilocybin and psilocin. The flowering plant Rauwolfia serpentina which contains reserpine was a common medicine in India around 1000 BC. Consumption of rye and related cereals contaminated with the fungus Claviceps purpurea causes ergot poisoning and ergotism in humans and other mammals. The first indole alkaloid, strychnine, was isolated by Pierre Joseph Pelletier and Joseph Bienaimé Caventou in 1818 from the plants of the Strychnos genus. Classification Depending on their biosynthesis, two types of indole alkaloids are distinguished; isoprenoids and non-isoprenoids. Non-isoprenoid: Simple derivatives of indoleSimple derivatives of β-carbolinePyrroloindole alkaloidsIsoprenoid: Non-isoprenoid indole alkaloids The number of known non-isoprenoid indole alkaloids is small compared to the number of indole alkaloids. Pyrolo-indole alkaloids
Ayahuasca and the Vines of Politics « Psychedelic Press UK Salvation by drfranken The following article has been written and contributed to PsypressUK by the Reverend Nemu, author of Nemu’s End: The History, Psychology, and Poetry of the Apocalypse and the Nemu’s End blog, with special thanks to the other Devilish Dan. We’d like to extend our thanks to the Reverend for his time and effort writing this article. After bubbling and brewing away for millennia in the Amazon, ayahuasca began seeping out through the foliage at the turn of the 20th century. Ayahuasca contains N,N-Dimethyltryptamine (DMT), which is internationally scheduled under the Convention on Psychotropic Substances. Media interest in the UK began in 1996. The press tended to follow this format, beginning with confusion, nausea, or occasionally terror, and concluding with a degree of respect for the “gentle, kind and thoughtful” [iv] members of the community, or asking “why shouldn’t they do what they do?” Mr. Demeter by drfranken Canadian customs seized some tea in 2000.
Cocaine Cocaine (INN) (benzoylmethylecgonine, an ecgonine derivative) is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" and the alkaloid suffix "-ine", forming "cocaine". It is a stimulant, an appetite suppressant, and a nonspecific voltage gated sodium channel blocker, which in turn causes it to produce anaesthesia at low doses. Biologically, cocaine acts as a serotonin–norepinephrine–dopamine reuptake inhibitor, also known as a triple reuptake inhibitor (TRI). It is addictive due to its effect on the mesolimbic reward pathway. It is markedly more dangerous than other CNS stimulants, including the entire amphetamine drug class, at high doses due to its effect on sodium channels, as blockade of Nav1.5 can cause sudden cardiac death. Unlike most molecules, cocaine has pockets[clarification needed] with both high hydrophilic and lipophilic efficiency, violating the rule of hydrophilic-lipophilic balance. Medical effects Acute
"Ayahuasca and Creativity" -- Benny Shanon, Ph.D. Ayahuasca and Creativity Benny Shanon, Ph.D., Department of Psychology, The Hebrew University PDF version of this document As indicated in previous publications (Shanon, 1997, 1998a, 1999) I am a cognitive psychologist who is studying the phenomenology of the ayahuasca experience. My study is based on extended firsthand experience as well as on the interviewing of a great number of persons in different places and contexts. In the publications cited the reader can find background information about both ayahuasca and the program of my research; for further theoretical discussion, see my forthcoming book The Antipodes of the Mind: Charting the Phenomenology of the Ayahuasca Experience. Phenomenologically, the effects of ayahuasca are multifarious -- they include hallucinatory effects in all perceptual modalities, psychological insights, intellectual ideations, spiritual uplifting and mystical experiences. As explained in Shanon (1998b), ayahuasca can also induce very impressive ideations.
The Heroine of Heroin – Upvoted Tracey Helton (Reddit user traceyh415) is the focus of this week’s episode. We discuss her depression growing up, how she became addicted to heroin, life as a homeless heroin addict, being the subject of the HBO documentary Black Tar Heroin, how she got clean, her involvement in harm reduction, how she got involved in Reddit’s opiates community, Naloxone, and how she saved the lives of over 120 users by sending naloxone to those with no access. Hold On "I lived in an all-female Pentecostal 'discipleship program' in rural Arkansas ... The Wave "Sailing remains one of the best things in my life. Four Walls and a Roof (Part One) "Our tent is a house. Tryptoline Tryptoline, also known as tetrahydro-β-carboline and tetrahydronorharmane, is a natural organic derivative of beta-carboline. It is an alkaloid chemically related to tryptamines. Derivatives of tryptoline have a variety of pharmacological properties and are known collectively as tryptolines. Pharmacology Tryptolines are also potent reuptake inhibitors of serotonin and epinephrine, with a significantly greater selectivity for serotonin. Although the in vivo formation of tryptolines has been a matter of controversy, they have profound pharmacological activity. There is evidence that tryptolines may be potent neurotoxins that may play a role in Parkinson's Disease See also References H.
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