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http://drupal.org/project/blueprint

Blueprint

Blueprint is a starter Drupal theme meant to make development of custom themes faster. Version 2.0 is now out! The big improvements are added customization settings on the theme settings page, right-to-left language support, and a more robust system for sub-theming, including a basic starter theme.
Blueprint is a CSS framework that can save you time and headaches when working on any project that involves HTML and CSS, whether it be with Rails, PHP, or just laying out an HTML page.

A Closer Look At the Blueprint CSS Framework

http://net.tutsplus.com/tutorials/html-css-techniques/a-closer-look-at-the-blueprint-css-framework/
This theme is based on the 960 Grid System by Nathan Smith. Details on its background can be found in a journal entry . http://drupal.org/project/ninesixty

NineSixty (960 Grid System)

Which CSS Grid Framework Should You Use for Web Design?

http://net.tutsplus.com/tutorials/html-css-techniques/which-css-grid-framework-should-you-use-for-web-design/ Ever wondered how all those slick “magazine” themes for WordPress and other platforms were created? Many, if not all, were designed using a CSS Grid Framework – at least in essence if not in actual fact. That is, you can use an existing CSS framework or build your own from scratch.