Anxiolytic
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An anxiolytic (also antipanic or antianxiety agent ) [ 1 ] is a drug used for the treatment of anxiety and its related psychological and physical symptoms. Anxiolytics have been shown to be useful in the treatment of anxiety disorders .
Anxiolytic - Wikipedia, the free encyclopedia
Azapirone - Wikipedia, the free encyclopedia
Azapirones are a class of drugs used as anxiolytics and antipsychotics . [ 1 ] [ 2 ] [ 3 ] [ 4 ] They are commonly employed as augmentations to antidepressants like the selective serotonin reuptake inhibitors (SSRIs) as well. [ 5 ] [ 6 ] [ 7 ] [ 8 ] [ 9 ]
Tandospirone ( Sediel ), also known as metanopirone , is an anxiolytic and antidepressant used in China and Japan , where it is marketed by Dainippon Sumitomo Pharma . It is a member of the azapirone and piperazine chemical classes and is closely related to other agents like buspirone and gepirone .
Tandospirone - Wikipedia, the free encyclopedia
Gepirone - Wikipedia, the free encyclopedia
Gepirone ( Ariza , Variza ; BMY-13,805 , ORG-13,011 ) is a psychoactive drug and research chemical of the piperazine and azapirone chemical classes .
Eptapirone ( F-11,440 ) is a very potent and highly selective 5-HT 1A receptor full agonist of the azapirone class. [ 1 ] [ 2 ] Its affinity for the 5-HT 1A receptor is 4.8 nM (K i ) or 8.33 (pK i ), and its intrinsic activity is 100% or equal to that of serotonin . [ 1 ] Eptapirone and its relatives such as F-13,640 and F-15,599 were developed under the notion that high receptor-activating efficacy is required for the maximal therapeutic benefits of 5-HT 1A receptor agonists to be realized, underlying the poor clinical effectiveness of currently marketed agents like buspirone and tandospirone which act as mere weak-moderate partial agonists . [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ edit ] Rodent studies
Eptapirone - Wikipedia, the free encyclopedia
Buspirone - Wikipedia, the free encyclopedia
Buspirone (pronounced / ˈ b juː s p ɨ r oʊ n / BEW -spi-rohn ; trade name Buspar , pronounced BYOO -spar ) is an anxiolytic psychoactive drug of the azapirone chemical class , and is primarily used to treat generalized anxiety disorder (GAD) Bristol-Myers Squibb (BMS) gained FDA approval of buspirone in 1986 for treatment of GAD. The patent on Buspar by Bristol-Myers Squibb expired in 2001, and buspirone is available as a generic .
Pregabalin ( INN ) ( / p r ɨ ˈ ɡ æ b əl ɨ n / ) is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults. [ 1 ] It has also been found effective for generalized anxiety disorder and is (as of 2007) approved for this use in the European Union. [ 1 ] It was designed as a more potent successor to gabapentin . Pregabalin is marketed by Pfizer under the trade name Lyrica .
Pregabalin - Wikipedia, the free encyclopedia
Venlafaxine ( brand name : Effexor or Efexor ) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. [ 2 ] [ 3 ] [ 4 ] First introduced by Wyeth in 1993, now marketed by Pfizer , it is licensed for the treatment of major depressive disorder (MDD), as a treatment for generalized anxiety disorder , and comorbid indications in certain anxiety disorders with depression. In 2007, venlafaxine was the sixth most commonly prescribed antidepressant on the U.S. retail market, with 17.2 million prescriptions. [ 5 ]
Venlafaxine - Wikipedia, the free encyclopedia
Hydroxyzine - Wikipedia, the free encyclopedia
Hydroxyzine ( / h aɪ ˈ d r ɒ k s ɨ z iː n / ; sold as Vistaril , Atarax ) is a first-generation antihistamine of the diphenylmethane and piperazine classes. It was first synthesized by Union Chimique Belge in 1956 and was marketed by Pfizer in the United States later the same year, [ 2 ] and is still in widespread use today. Hydroxyzine is used primarily as an antihistamine for the treatment of itching , allergies , hyperalgesia , motion sickness -induced nausea , and insomnia , as well as notably for the treatment of mild anxiety . [ 3 ] Even though it is an effective sedative , hypnotic , analgesic , and tranquilizer , it shares almost none of the abuse , dependence , addiction , and toxicity potential of other drugs used for the same range of therapeutic reasons. [ citation needed ]Meclozine - Wikipedia, the free encyclopedia
Meclozine ( INN , [ 1 ] or meclizine ) is an antihistamine considered to be an antiemetic .Buclizine - Wikipedia, the free encyclopedia
From Wikipedia, the free encyclopedia Buclizine is an antihistamine and anticholinergic of the piperazine derivative family.Cyclizine - Wikipedia, the free encyclopedia
Cyclizine is an antihistamine drug used to treat nausea , vomiting and dizziness associated with motion sickness , vertigo and post-operatively following administration of general anaesthesia and opioids .A benzodiazepine / ˌ b ɛ n z ɵ d aɪ ˈ æ z ɨ p iː n / (sometimes colloquially " benzo "; often abbreviated " BZD ") is a psychoactive drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring. The first benzodiazepine, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955, and made available in 1960 by Hoffmann–La Roche , which has also marketed diazepam (Valium) since 1963. [ 1 ] Benzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA), which results in sedative , hypnotic ( sleep-inducing ), anxiolytic (anti-anxiety), anticonvulsant , muscle relaxant and amnesic action. [ 2 ] These properties make benzodiazepines useful in treating anxiety , insomnia , agitation , seizures , muscle spasms , alcohol withdrawal and as a premedication for medical or dental procedures. [ 3 ] Benzodiazepines are categorized as either short-, intermediate- or long-acting.