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Olanzapine (Zyprexa), an example of a second-generation antipsychotic An antipsychotic (or neuroleptic ) is a psychiatric medication primarily used to manage psychosis (including delusions , hallucinations , or disordered thought ), particularly in schizophrenia and bipolar disorder , and is increasingly being used in the management of non-psychotic disorders ( ATC code N05A). A first generation of antipsychotics, known as typical antipsychotics , was discovered in the 1950s.
The atypical antipsychotics (AAP) (also known as second generation antipsychotics ) are a group of antipsychotic tranquilizing drugs used to treat psychiatric conditions.
Amisulpride (sold as Solian , Sulpitac , Amitrex , Soltus or Amazeo ), is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder .
Asenapine ( INN , trade names Saphris , Sycrest ) is an atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder by Schering-Plough after its November 19, 2007 merger with Organon International .
Ziprasidone (marketed as Geodon , Zeldox by Pfizer ) was the fifth atypical antipsychotic to gain approval (February 2001) in the United States .
Risperidone ( / r ɨ ˈ s p ɛər ɨ d oʊ n / ri- SPAIR -i-dohn ) (trade name Risperdal , and generics) is an antipsychotic drug which is mainly used to treat schizophrenia (including adolescent schizophrenia), schizoaffective disorder , the mixed and manic states associated with bipolar disorder , and irritability in people with autism .
Olanzapine (trade name Zyprexa or in combination with fluoxetine Symbyax ) is an atypical antipsychotic , approved by the U.S.
Quetiapine ( pron.: / k w ɨ ˈ t aɪ . ə p iː n / kwi- TY -ə-peen ) (branded as Seroquel , Xeroquel , Ketipinor ), is an atypical antipsychotic approved for the treatment of schizophrenia , bipolar disorder , and in the XR version along with an SSRI to treat major depressive disorder . Annual sales are approximately $5.7 billion worldwide, with $2.9 billion in the United States. [ 1 ] The U.S. patent, [ 2 ] which was set to expire in 2011, received a pediatric exclusivity extension which pushed its expiration to March 26, 2012. [ 1 ] [ 3 ] The patent has already expired in Canada.
Clozapine is an atypical antipsychotic medication used in the treatment of schizophrenia , and is also sometimes used off-label for the treatment of bipolar disorder .
Aripiprazole ( pron.: / ˌ ɛər ɨ ˈ p ɪ p r ə z oʊ l / AIR -i- PIP -rə-zohl ; brand names: Abilify , Aripiprex ) is a partial dopamine agonist of the second generation class of atypical antipsychotics with additional antidepressant properties that is used in the treatment of schizophrenia , bipolar disorder , and clinical depression . It was approved by the U.S. Food and Drug Administration (FDA) for schizophrenia on November 15, 2002 and the European Medicines Agency on 4 June 2004; for acute manic and mixed episodes associated with bipolar disorder on October 1, 2004; as an adjunct for major depressive disorder on November 20, 2007; and to treat irritability in children with autism on 20 November 2009. [ 1 ] [ 2 ] Aripiprazole was developed by Otsuka in Japan , and in the United States , Otsuka America markets it jointly with Bristol-Myers Squibb .
Cannabidiol ( CBD ) is a cannabinoid found in cannabis .
Typical antipsychotics (sometimes referred to as first generation antipsychotics , conventional antipsychotics , classical neuroleptics , traditional antipsychotics , or major tranquilizers ) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia ). Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions.
Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs. It has the formula S(C 6 H 4 ) 2 NH.
Chlorpromazine (as chlorpromazine hydrochloride , abbreviated CPZ ; marketed in the United States as Thorazine and elsewhere as Largactil or Megaphen ) is a dopamine antagonist of the typical antipsychotic class of medications possessing additional antiadrenergic , antiserotonergic , anticholinergic and antihistaminergic properties used to treat schizophrenia . [ 1 ] [ 2 ] First synthesized on December 11, 1950, chlorpromazine was the first drug developed with specific antipsychotic action, and would serve as the prototype for the phenothiazine class of drugs, which later grew to comprise several other agents.
Perphenazine is a typical antipsychotic drug . Chemically, it is classified as a piperazinyl phenothiazine . It has been in clinical use for decades.