A genome-wide RNAi screen identifies novel targets of neratinib resistance leading to identification of potential drug resistant genetic markers. A genome-wide RNAi screen identifies novel targets of neratinib sensitivity leading to neratinib and paclitaxel combination drug treatments. Analysis of miRNA regulation suggests an explanation for ‘unexpected’ increase in target protein levels. Characterization of non-8â17 sequences uncovers structurally diverse RNA-cleaving deoxyribozymes. Long chains give new life to RNA world hypothesis. PNA-based artificial nucleases as antisense and anti-miRNA oligonucleotide agents. Positive regulatory dynamics by a small noncoding RNA: speeding up responses under temperature stress. Probabilistic RNA partitioning generates transient increases in the normalized variance of RNA numbers in synchronized populations of Escherichia coli. Real time RNA transcription monitoring by Thiazole Orange (TO)-conjugated Peptide Nucleic Acid (PNA) probes: norovirus detection.
Stochastic analysis of a miRNAâprotein toggle switch. Synthetic antibodies as tools to probe RNA-binding protein function. A Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8 E-mail: howard.lipshitz@utoronto.ca; Fax: 416-971-2494 ; Tel: 416-946-5296 b Department of Cell & Systems Biology and Department of Biology, University of Toronto at Mississauga, 3359 Mississauga Road, Mississauga, Ontario, Canada L5L 1C6 c Department of Biochemistry, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada E-mail: c.smibert@utoronto.ca; Fax: 416-978-8548 ; Tel: 416-946-5538 d Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, 160 College Street, Toronto, Ontario, Canada M5S 3E1.
The TNA world that came before the RNA one. Transcriptional regulation by miRNA mimics that target sequences downstream of gene termini.