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Service d'authentification de l'Inist-CNRS. Service d'authentification de l'Inist-CNRS. Service d'authentification de l'Inist-CNRS. Reports: Detailed mechanism for transposition by TnpA transposase involves DNA shape rather than direct protein-DNA recognition to generate an active nucleoprotein complex. A universal code for RNA recognition by PUF proteins. An Eyeful of RNA. Editor's Choice in Physiology Human retina showing the yellowish "horseshoe-shaped" atrophic region in the center, where the RPE cells have died, revealing the underlying choroid.

J. AMBATI, B. GELFAND, AND M. HANSON The paper H. The finding Millions of people suffer from macular degeneration, an aging-associated disease that slowly destroys central vision. The RNA Three years ago, while studying angiogenesis in the mouse eye, Ambati’s lab found that injecting short, double-helical fragments of RNA prevented new blood vessel growth. The enzyme Ambati’s lab tested different RNA-processing enzymes, and found that DICER1, which cuts pre-miRNA into its functional form, was reduced in the eyes of human patients suffering from late-stage macular degeneration. The therapy Preventing Alu accumulation with antisense drugs “offers hope for some kind of targeted therapy,” according to Orly Reiner of the Weizmann Institute of Science. An RNA-zipcode-independent mechanism that localizes Dia1 mRNA to the perinuclear ER through interactions between Dia1 nascent peptide and Rho-GTP. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.

Disease-associated mutations that alter the RNA structural ensemble. ExoCarta: A compendium of exosomal proteins and RNA. F1000 Research: post-publication peer review and data sharing. What are scientists doing to promote open access to data?

F1000 Research: post-publication peer review and data sharing

Rebecca Lawrence discusses a new publishing venture by one group of scientists, looking to shake up scientific publishing. Disclaimer: F1000 is not affiliated with the Wellcome Trust. Views expressed in this article are the author’s own. You only need to look at the recent increase in the number of meetings and workshops dedicated to the issues surrounding open science, open data and novel ways of sharing and communicating science (e.g. Wellcome Trust’s eLife) to see that we are on the verge of a transformation in scholarly communication. I work for Faculty of 1000, a post-publication review service, with a peer-nominated ‘Faculty’ of 10,000 experts that identifies important publications in biological and medical research. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. High throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Molecular insights into the ligand-controlled organization of the SAM-I riboswitch. Proteome-wide search reveals unexpected RNA-binding proteins in Saccharomyces cerevisiae. Reports: Chemical signaling in the gastrointestinal tract. Reports: CRISPR-Cas: an adaptive immunity system in prokaryotes. Reports: Emerging technologies for the genomic analysis of cancer. Reports: Recent advances in RNA sequence analysis. Reports: Structure of spliceosomal ribonucleoproteins. Reports: Sweet memories: epigenetic control in flowering. Reports: Ubiquitous antisense transcription in eukaryotes: novel regulatory mechanism or byproduct of opportunistic RNA polymerase?

RNA methylation by Radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift. Service d'authentification de l'Inist-CNRS. Service d'authentification de l'Inist-CNRS. Service d'authentification de l'Inist-CNRS. Service d'authentification de l'Inist-CNRS. Service d'authentification de l'Inist-CNRS. Service d'authentification de l'Inist-CNRS.

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