Alnylam ATTR Program on Track as Company Explores Subcutaneous Delivery for Cholesterol Drug. qPCR & NGS 2013 - confirmed talks. MiRview® lung – Final Approval for Rosetta Genomics’ microRNA Diagnostic Allows Identification of Four Major Subtypes of Lung Cancer. PHILADELPHIA and REHOVOT, Israel, Nov. 6, 2012 /PRNewswire/ – Rosetta Genomics (NASDAQ: ROSG), a leading developer and provider of microRNA-based molecular diagnostic assays, announces that the New York State Department of Health has given the Company final approval for its miRview® lung assay following conditional approval issued in June 2012.
With this final approval, Rosetta Genomics can continue to offer the miRview® lung assay in all 50 U.S. states. New York is the only U.S. state that requires an independent regulatory review process for laboratory-developed tests. RNA-Seq: Differential Expression in Depth - Day 1 - XGen Congress Expo. RNA-Seq is perhaps the most complex NGS application.
The range, depth, and complexity of a human transcriptome is far from fully characterized. RNA transcripts, by nature, are moving targets, making their characterization and quantification difficult. A single RNA-Seq experiment can provide relatively unbiased sequence information for analysis of gene expression, novel transcripts, novel isoforms, alternative splice sites, allele-specific expression, cSNPs, and rare transcripts, depending on read depth.
CHI’s Third Annual RNA-Sequencing: Differential Expression in Depth conference centers on NGS technical improvements providing new insights into our active genome. STAR: ultrafast universal RNA-seq aligner. Life Sciences & Mathematics & Physical Sciences. Cell Stem Cell - Attenuation of miR-126 Activity Expands HSC In Vivo without Exhaustion. <div class="msgBox" style="margin-top:10px;"><span class="errMsg"><div>JavaScript is disabled on your browser.
Please enable JavaScript to use all the features on this page. </div></span></div><br /> Article. Alnylam. Workshop: LC Sciences / Norgen Biotek - Degradome Sequencing / Plant RNA Extraction Methods (Plant and Animal Genome XXI Conference) Regulus Announces $80.9 Million in Total Gross Proceeds from IPO and Other Recent Financial Transactions. LA JOLLA, Calif., Nov. 5, 2012 /PRNewswire/ – Regulus Therapeutics Inc. ( NASDAQ : RGLS), a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, summarized today its recent financing activity that the company expects will enable Regulus to execute its current strategic objectives for the foreseeable future.
In connection with Regulus’ Initial Public Offering (IPO), which closed on October 10, 2012, and other recent financial transactions, Regulus has raised $80.9 million in gross proceeds, including: “We are excited to have reached this important point in Regulus’ life,” said Kleanthis G. Xanthopoulos, Ph.D., President and CEO of Regulus. ”With the company well capitalized for the foreseeable future, we are focused on building a meaningful clinical portfolio and realizing the transformative potential of microRNA therapeutics.”
About Regulus Regulus Therapeutics Inc. Forward-Looking Statements SOURCE Regulus Therapeutics Inc. MicroBEnet: The microbiology of the Built Environment network. Key Facts Ribosomal RNAs (rRNA) perform critical functions in the ribosome that allow protein synthesis to occur.The genes that encode rRNAs evolve (i.e. change sequence over time) in a very unique manner that makes them excellent “markers” to trace evolutionary history and powerful tools to identifying species from sequence data.
The Ribosome The ribosome is a cellular machine found in all organisms. It serves to convert the instructions found in messenger RNA (mRNA, which itself is made from instructions in DNA) into the chains of amino-acids that make up proteins. That is, the ribosome is responsible for the synthesis of proteins. 02. Reducing sequencing bias of small RNAs. Reducing sequencing bias of small RNAs The use of nucleic acid modifying enzymes has driven the rapid advancement in molecular biology.
Understanding their function is important for modifying or improving their activity. However, functional analysis usually relies upon low-throughput experiments. Here we present a method for functional analysis of nucleic acid modifying enzymes using next generation sequencing. The Kuhn Laboratory at TSRI:Home page - Kuhn Lab at The Scripps Research Institute. The Art of MicroRNA Research. Abstract Originally identified as moderate biological modifiers, microRNAs have recently emerged as powerful regulators of diverse cellular processes with especially important roles in disease and tissue remodeling.
The rapid pace of studies on microRNA regulation and function necessitates the development of suitable techniques for measuring and modulating microRNAs in different model systems. This review summarizes experimental strategies for microRNA research and highlights the strengths and weaknesses of different approaches. The development of more specific and sensitive assays will further illuminate the biology behind microRNAs and will advance opportunities to safely pursue them as therapeutic modalities. Key Words: Over the past decade, it has become progressively more clear that a large class of small noncoding RNAs, known as microRNAs (miRNAs), function as important regulators of a wide range of cellular processes by modulating gene expression.
RNA therapy to control gene expression. Multimedia Marketing Solutions - Thomson Reuters Corporate Solutions. You’re in the Information Business Global markets. 24-hour news cycles.
Alnylam Pharmaceuticals, Inc. : Alnylam Pharmaceuticals, Inc. share news and information. RegRNA: A Regulatory RNA Motifs and Elements Finder. Sequence View. Mrh6esjy?utm_source=dlvr. Arrowhead Reports Fiscal 2012 Fourth Quarter and Year-End Financial Results. Mirna Division Of Genomics And Rnomics Biocenter Innsbruck Pdf. Least stressful job of 2013: writing for Forbes. This morning I was alerted to a Forbes piece written by Susan Adams on the Least Stressful Jobs of 2013.
Number one on the list? University Professor. Chemical probe finds fungal organism function: Activity-based protein profiling suggests how fungus becomes pathogenic. (Phys.org)—Two unique chemical probes designed at Pacific Northwest National Laboratory are helping scientists find how a pathogenic organism responsible for a severe lung infection thrives in human serum.
These probes use multiplexed activity-based protein profiling (ABPP), which revealed significant changes in Aspergillus fumigatus metabolism and stress response when placed in culture with human serum over time. A. fumigatus spores are ubiquitous in the atmosphere, and everybody inhales an estimated several hundred spores each day. But for people whose immune response is compromised from taking immunosuppressive drugs, by irradiation or malnutrition, or by diseases such as cancer or AIDS, this opportunistic pathogen is responsible for pulmonary invasive aspergillosis (IA). Patients with IA are usually critically ill, and the disease is difficult to cure. 'Universal' personality traits don't necessarily apply to isolated indigenous people. Five personality traits widely thought to be universal across cultures might not be, according to a study of an isolated Bolivian society.
Researchers who spent two years looking at 1,062 members of the Tsimane culture found that they didn't necessarily exhibit the five broad dimensions of personality – openness, conscientiousness, extraversion, agreeableness and neuroticism – also known as the "Big Five. " The American Psychological Association's Journal of Personality and Social Psychology published the study online Dec. 17. While previous research has found strong support for the Big Five traits in more developed countries and across some cultures, these researchers discovered more evidence of a Tsimane "Big Two:" socially beneficial behavior, also known as prosociality, and industriousness. These Big Two combine elements of the traditional Big Five, and may represent unique aspects of highly social, subsistence societies.
Korean Society of Plant Pathology. New study defines the long-sought structure of a protein necessary for cell-cell interaction. Scientists know that cells in all higher organisms cells need to bind to each other for the development, architecture, maintenance and function of tissues. Mysteries have remained, however, about exactly how cells manage this feat.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have now solved part of this puzzle by defining the structure of a protein known as α-catenin, which is essential to this process. The work was published online ahead of print on January 6, 2012, by the journal Nature Structural & Molecular Biology. Scientopia. Questcor Pharmaceuticals to Acquire BioVectra Inc. Codelivery of zoledronic acid and double-stranded RNA from core-shell. Researchers reveal an RNA modification influences thousands of genes. May 18, 2012Over the past decade, research in the field of epigenetics has revealed that chemically modified bases are abundant components of the human genome and has forced us to abandon the notion we've had since high school genetics that DNA consists of only four bases. Now, researchers at Weill Cornell Medical College have made a discovery that once again forces us to rewrite our textbooks.
This time, however, the findings pertain to RNA, which like DNA carries information about our genes and how they are expressed. The researchers have identified a novel base modification in RNA which they say will revolutionize our understanding of gene expression. Uncovering the role of sperm RNA in early post-fertilization development. Sperm give new embryos more than just a copy of their genes: they also contribute RNAs, molecules similar to DNA that play many essential roles in switching genes on or off, and in regulating how much protein is produced from each gene.
However, very little is known about sperm RNAs or their functions. Now, a RIKEN team led by Mitsuoki Kawano of the Omics Science Center, Yokohama, Japan, has identified two novel RNAs that may influence the early development of the embryo. Kawano, now at Niigata University of Pharmacy and Applied Life Sciences, and colleagues surveyed the RNA complement of mouse sperm using deep sequencing, which identifies both the sequence and frequency of each RNA.
Bacterial Pathogenomics. Sequencing data: I want the truth! (You can’t handle the truth!) Two sequencing papers caught my eye this week. Non_coding_rna_detail_180811.pdf?utm_source=dlvr. Epigenetics Market is Growing at a CAGR of 25% & Expected to Reach $8 Billion by 2017 by MarketsandMarkets. (PRWEB) January 09, 2013 The report “Epigenetics Market (Epigenomics, DNA Methylation, Histone Modifications, RNA interference, Cancer Therapeutics, Personalized Medicine) (2012 - 2017)” analyses the global epigenetics market by region, applications and epigenetic mechanisms with five year revenue forecasts. It also identifies the factors driving and restraining the global epigenetics market with analysis of trends, opportunities and challenges. The market is segmented and the revenue is forecasted on the basis of major regions such as America, Europe, Asia and Rest of the World (ROW) covering the key countries for each region.
Synthetic Biology / EteRNA is a browser based game, that engages users to solve puzzles related to the folding of RNA molecules. The seven wonders of the RNA world. By Manny Ares and Tracy Johnson. Citation Query PB, Steitz TA: The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution. The origin and evolution of the ribosome. Silence Therapeutics raises £5mln as Henderson buys in.
SBI Holdings, Inc. : SBI Holdings, Inc. share news and information. Microsponge-rna-delivery-0227. Professor develops program to decode RNA - News. Published: Sunday, February 26, 2012 Updated: Sunday, February 26, 2012 16:02. Turning off Small RNA: Michigan Tech Scientist Designs a New Tool for Breaking the Epigenetic Code. February 28, 2012— For the last dozen years, scientists have known that minuscule strings of genetic material called small RNA are critically important to our genetic makeup.
Did an earlier genetic molecule predate DNA and RNA. In the chemistry of the living world, a pair of nucleic acids-DNA and RNA-reign supreme. As carrier molecules of the genetic code, they provide all organisms with a mechanism for faithfully reproducing themselves as well as generating the myriad proteins vital to living systems. Two RNA studies give clues to neurodegeneration. Two independent studies have suggested new targets for treating neurodegenerative diseases. Errors in a process known as splicing, where the sections of a gene that don't code for the final protein product are cut out of a 'raw' copy of DNA (known as pre-mRNA), is known to produce dysfunctional proteins.
Scientists create novel RNA repair technology. v329567_8-k.htm?utm_source=dlvr. RNA-only genes: The origin of species? Structural Biochemistry/RNA World Hypothesis. U.S. Securities and Exchange Commission. How Cells Remove RNA from DNA Strands. The Plasmodium genome resource. 10 rules-of-thumb in genomics. Rare, not rare, rare, not rare (and this is not about burgers, it's about ocean bacteria) Internship - Scientific Data Visualisation. Osher UCSD: Redrawing Lines Between Chimps and Humans - UCSD-TV - University of California Television. Illuminating life: How RNA, after a century in the shadows, emerged into the spotlight.