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Take note, DNA and RNA: it's not all about you. Life on Earth may have begun with a splash of TNA – a different kind of genetic material altogether. Because RNA can do many things at once, those studying the origins of life have long thought that it was the first genetic material. But the discovery that a chemical relative called TNA can perform one of RNA's defining functions calls this into question. Instead, the very first forms of life may have used a mix of genetic materials.
Glowing genes: White arrows show hot spots of ADAR activation; courtesy of Reenan Lab/Brown University It’s a long way from gene to protein. The dogmatic scenario is: DNA gets transcribed into RNA, which gets translated into protein . But in real life, and in real living things, the workings aren’t quite that simple.
Our colleagues over at Nature Reviews Genetics have put together this very cool animation of RNA interference. Check it out. RNA interference (RNAi) is an important pathway that is used in many different organisms to regulate gene expression. This animation introduces the principles of RNAi involving small interfering RNAs (siRNAs) and microRNAs (miRNAs).
The geneticist whose claimed to find a new mechanism of genetic regulation is defending her work against critics. Vivian Cheung of the University of Pennsylvania in Philadelphia says that her team stands by a May paper in which it reported that it had found more than ten thousand sites where transcribed RNA differed from an individual’s corresponding DNA sequence. The paper raised the possibility of an as-yet unknown mechanism that performs a new form of “ RNA editing” in our cells. Cheung also says that new data from her own group and from others ( PDF ) supports the finding.
hi, sitara Your solution is hazy because of contamination with chloromphenecol For to rectify this problem you give IPA teatment once more time and washing of 70% IPA must be done at room temprature. it will provide environmnet to washout the protein and other contamination. after that you dry it properly, not over dry. Only IPA smell should be going out from the tube
A paper that appeared to find evidence for a new mechanism of genetic regulation has been challenged by an analysis released today. In May, a team led by Vivian Cheung of the University of Pennsylvania in Philadelphia reported that in an analysis of 27 people, it had found 10,210 sites where transcribed RNA differed from an individual’s corresponding DNA sequence . The finding was startling because it implied that there might be an as-yet undiscovered mechanism of ‘ RNA editing’ that could disrupt the central dogma, the process whereby DNA is faithfully transcribed into matching sequences of RNA , which are translated into proteins.