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For example, many viruses produce double-stranded (ds)RNA during their life cycle and the RNA interference (RNAi) mechanism is thought to recognize this structural feature to initiate a silencing response. Now, UMass Medical School researchers have identified a mechanism related to RNAi that scans for intruders not by recognizing dsRNA or some other aberrant feature of the foreign sequence, but rather by comparing the foreign sequences to a memory of previously expressed native RNA. Once identified, an “epigenetic memory” of the foreign DNA fragments is created and can be passed on from one generation to the next, permanently silencing the gene.
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Kseniakrasileva : Gary Schroth provides an h... Life_Sciences_ : Struc... Bio_Network : Struc... Life_Sciences_ : Deter... Bio_Network : Deter...