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Three groups 1–3 today throw fuel on the debate surrounding a researcher’s claim to have discovered a twist in the mechanism whereby genes are translated into proteins. The paper, published in Science last May 4 , suggested a revision in the central dogma, which holds that the RNA transcripts used as templates for protein assembly are generally faithful matches to the original DNA.
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It is clear that RNA has a diverse set of functions and is more than just a messenger between gene and protein.
MicroRNAs (miRNAs) regulate mRNA targets through perfect pairing with their seed region (positions 2–7). Recently, a precise genome-wide map of miRNA interaction sites in mouse brain was generated by high-throughput sequencing and analysis of clusters of ~50-nucleotide mRNA tags cross-linked to Argonaute (Ago HITS-CLIP). By analyzing Ago HITS-CLIP 'orphan clusters'—Ago binding regions from HITS-CLIP that cannot be explained by canonical seed matches—we have now identified an alternative binding mode used by miRNAs.
Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activation : Nature Chemical BiologyFollowing ribosomal peptide bond formation, the reaction products, peptidyl-tRNA and deacylated tRNA, need to be translocated from the A- and P-sites to the P- and E-sites, respectively. This process is facilitated by the GTPase elongation factor G (EF-G).
Biophysicist at Yale University in New Haven, Connecticut. Shared 2009 Nobel Prize in Chemistry for knowledge of the structure and function of the ribosome — the intracellular machine that builds proteins from instructions carried by RNA.
Primary authors These authors contributed equally to this work.
Primary authors These authors contributed equally to this work. Blake Wiedenheft & Gabriel C.