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RNAi
Three groups 1–3 today throw fuel on the debate surrounding a researcher’s claim to have discovered a twist in the mechanism whereby genes are translated into proteins. The paper, published in Science last May 4 , suggested a revision in the central dogma, which holds that the RNA transcripts used as templates for protein assembly are generally faithful matches to the original DNA.
RNA editing study under intense scrutiny
Modular regulatory principles of large non-coding RNAs : Nature
It is clear that RNA has a diverse set of functions and is more than just a messenger between gene and protein.
An alternative mode of microRNA target recognition : Nature Structural & Molecular Biology
MicroRNAs (miRNAs) regulate mRNA targets through perfect pairing with their seed region (positions 2–7). Recently, a precise genome-wide map of miRNA interaction sites in mouse brain was generated by high-throughput sequencing and analysis of clusters of ~50-nucleotide mRNA tags cross-linked to Argonaute (Ago HITS-CLIP). By analyzing Ago HITS-CLIP 'orphan clusters'—Ago binding regions from HITS-CLIP that cannot be explained by canonical seed matches—we have now identified an alternative binding mode used by miRNAs.Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activation : Nature Chemical Biology
Following ribosomal peptide bond formation, the reaction products, peptidyl-tRNA and deacylated tRNA, need to be translocated from the A- and P-sites to the P- and E-sites, respectively. This process is facilitated by the GTPase elongation factor G (EF-G).
Primary authors
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides : Nature
Biophysicist at Yale University in New Haven, Connecticut. Shared 2009 Nobel Prize in Chemistry for knowledge of the structure and function of the ribosome — the intracellular machine that builds proteins from instructions carried by RNA.
Lunchtime science : Nature
Pathogenic exon-trapping by SVA retrotransposon and rescue in Fukuyama muscular dystrophy : Nature
Primary authorsSUMO1-dependent modulation of SERCA2a in heart failure : Nature
Primary authors These authors contributed equally to this work.Primary authors These authors contributed equally to this work. Blake Wiedenheft & Gabriel C.
Structures of the RNA-guided surveillance complex from a bacterial immune system : Nature
Primary authors