Staging and Grading Cancer. If left untreated, cancers often go through three stages: 1.
Local growth and damage to nearby tissues Cancer cells multiply quickly. Stages of Colorectal Cancer with Dukes and TNM staging system. 1. Older colorectal cancer stages is based on Dukes staging system. Stage 1: (Dukes'A): 0) lesions limited to mucosal layer (carcinoma in situ). Union for International Cancer Control.