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The Biological Computation group is conducting research to uncover fundamental principles of biological computation: what cells compute, how and why.
What is Systems Biology? Systems Biology is a rapidly evolving discipline that seeks to determine how complex biological systems function by integrating experimentally derived information through mathematical and computing solutions. Through an iterative process of experimentation and modelling, systems biology aims to understand how individual components interact to govern the functioning of the system as a whole.
Integrated genetic and computation methods for in planta cytometry Fernán Federici, Lionel Dupuy, Laurent Laplaze, Marcus Heisler & Jim Haseloff Nature Methods , 9, 483–485 (2012). The paper describes the coupled use of specifically localized fluorescent gene markers and image processing for automated quantitative analysis of cell growth and genetic activity across living plant tissues.
The Ellis Lab is actively involved in advancing foundational synthetic biology and applying synthetic biology to a variety of different research areas. Our research is interdisciplinary, with members coming from biology, chemistry, maths and engineering backgrounds.
We work in three areas: a) Synthetic Biology: We work on the fundamentals of designing novel multi-enzyme reaction networks for the production of high-value-added chemicals in vivo and in vitro >> If you want to find out more about synthetic biology, you can do that here or here .
Our ambition is to understand living systems on the scale of individually active and interactive molecules such as proteins, lipids and nucleic acids. To this end, single molecule optical techniques as well as AFM are developed and combined to the point where static and dynamic molecular heterogeneity in cells and membranes can be resolved in real time. To quantitatively understand the intricate relationships of biomolecules in their native environments, it is often required to reconstitute selected subsystems in biomimetic environments and investigate them under defined conditions.