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The regrowth of amputated limbs and the distal tips of digits represent models of tissue regeneration in amphibians, fish and mice. For decades it had been assumed that limb regeneration derived from the blastema, an undifferentiated pluripotent cell population thought to be derived from mature cells via dedifferentiation.
Affiliations Carnegie Museum of Natural History, Pittsburgh, Pennsylvania 15213, USA Zhe-Xi Luo Chinese Academy of Geological Sciences, Beijing 100037, China Chong-Xi Yuan & Qiang Ji Beijing Museum of Natural History, Beijing 100050, China Qing-Jin Meng
Affiliations School of International and Public Affairs, Columbia University, New York, New York 10027, USA Solomon M.