Home : PSI-Nature Structural Biology Knowledgebase. Structural Biochemistry and Bioinformatics 2001: Lecture notes. 18.417: Introduction to Computational Molecular Biology. Syllabus Computational Molecular Biology, also known as Bioinformatics, applies computational methods to molecular biology.
Computation has become essential for biological and bio-medical research to deal with the ever-growing amount of biological data and complexity of biological systems. The class focuses on structural bioinformatics, which refers to the analysis and prediction of the three-dimensional structure of biological macromolecules such as DNA, RNA, and proteins. Concerning RNA structure, we will discuss fundamental and advanced techniques for its prediction and analysis. Introducing advanced comparative approaches, the class will cover pairwise and multiple sequence alignment. The class addresses grad students, senior and junior undergrads interested in the application of mathematical and computational methods to structural biology and also for biologists and biochemists interested in the algorithmic foundations of the approaches used in this field. Topics Course information. Free Online MIT Course Materials for High School.
Nucleic Acids - Structure Components and structure of the nucleic acids.
Polymerization occurs through the condensation of the phosphate on the 5' carbon and OH on the 3' carbon linkage. 7.012 Introduction to Biology, Fall 2004 Prof. Eric Lander, Prof. Robert Weinberg, Dr. Course Material Related to This Topic: Back to Top Nucleic Acids - Bases and Nomenclature Structure and nomenclature of the five nitrogenous bases that form parts of DNA and RNA-thymine, adenine, cytosine, guanine, and uracil. Nucleic Acids - Polymerization Polymerization occurs by formation of phosphodiester bonds in the 5' to 3' direction. Exploring Life's Origins: Resources for Educators. Please note that animations and illustrations from the Exploring Life's Origins project are licensed under a Creative Commons License, and may be freely downloaded for non-commercial uses with proper attribution.
See bottom of page for more information. DOWNLOAD MOVIES click to view movies in your browser, or right click to download movie. RNA folding movie, as shown in the "What is RNA? " section. - download Quicktime movie (9 MB) Movie of RNA polymerization on clay, as shown in the "Nucleic Acids" section Non-enzymatic RNA polymerization movie, as shown in the "Nucleic Acids" section Replicase ribozyme movie, as shown in the "Nucleic Acids" section. - download Quicktime movie (26 MB) Movie describing the need for compartmentalization, as shown in the "Fatty Acids" section. - download Quicktime movie (18 MB) Formation of fatty acids in a geyser movie, as shown in the "Fatty Acids" section. - download Quicktime movie (191 MB) DNA, RNA and protein illustration, as shown in the "What is RNA?