Am J Dent Sci. 1896 Sep; 30(5): 204–206. "Borism," or the Toxic Effects of Borax. King Saud University - 2001 - Thèse en ligne : Boric acid enhances in vivo Ehrlich ascites carcinoma cell proliferation in Swiss albino mice. Virginia Polytechnic Institute and State University 09/11/09 Thèse en ligne: Effect of Alternative Household Sanitizing Formulations Including: Tea Tree Oil, Borax, and Vinegar, to Inactivate Foodborne Pathogens on Food Contact Surfaces. CFS_GOV_HK - JULY 2009 - Use of Boric Acid and Borax in Food. Introduction Boric acid (H 3BO 3) and borax (Na 2B 4O 7‧10H 2O) are both boron-containing compounds which are widely used in a wide range of consumer products such as glass and fire retardants.
They have also been used in food preparations to give food a better texture and prolong its shelf life.Food surveillance findings in the past have revealed that boric acid had been added to food including rice dumplings and root starch jelly as a preservative. Safety of Boric Acid and Borax At low concentrations, borax can be converted to boric acid in body prior to absorption.Boric acid can produce toxic symptoms including vomiting, diarrhoea and abdominal pain in humans upon excessive intake. Animal studies indicate that ingestion of large amount of boric acid may cause adverse reproductive and developmental effects. Testicular lesions and sterility have been observed in experimental animals. Regulatory Control Advice to the Public Advice to the Trade Do not use boric acid or borax in food. Vlaams Diergeneeskundig Tijdschrift, 2009, 78 Antimicrobial activity of an acetic and boric acid solution against Staphylococcus pseudintermedius.
PRO LIGNO - DEC 2007 - EVALUATION OF BORIC ACID/VEGETABLE OIL COMBINATIONS FOR WOOD BIOLOGICAL RESISTANCE AND REDUCTION OF BORON. Florent LYON PhD student-Laboratory of mechanics and civil engineering-University of Montpellier II Adress: CC 048 Place Eugene Bataillon, 34095 Montpellier Cedex 5, France. Tel : 0033 (0) 467149344. Fax : 0033 (0) 467144792. E_mail: email@example.com Marie France THEVENON PhD. -CIRAD PERSYST - UPR 40. Laboratoire de préservation des bois Adress: TA B-40/16. 73, rue Jean Francois Breton. 34398 Montpellier Cedex 5 - France. Tel : 0033 (0) 467616523.
Won Joung HWANG PhD student-Research Institute of Sustainable Humanosphere, Kyoto University Adress: Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan. Yuji IMAMURA Prof. Joseph GRIL Prof. Antonio PIZZI Prof. Abstract: In the light of European directive (98/8/CE) on efficacy and toxicity of biocides coming into force on 2008, wood preservation research is now focussing on environmentally-friendly wood preservatives. Key words: boric acid, vegetable oil, wood preservation, termite test, fungi test. J. Antimicrob. Chemother. (2009) Antifungal mechanisms supporting boric acid therapy of Candida vaginitis.
+ Author Affiliations *Corresponding author. Tel: +1-515-271-1559; Fax: +1-515-271-1644; E-mail: firstname.lastname@example.org Received June 13, 2008. Revision requested August 4, 2008. Revision received September 24, 2008. Accepted October 28, 2008. Abstract Background Boric acid is a commonly cited treatment for recurrent and resistant yeast vaginitis, but data about the extent and mechanism of its antifungal activity are lacking. Objectives The aim of this study was to use in vitro methods to understand the spectrum and mechanism of boric acid as a potential treatment for vaginal infection. Methods Yeast and bacterial isolates were tested by agar dilution to determine the intrinsic antimicrobial activity of boric acid. Results C. albicans strains (including fluconazole-resistant strains) were inhibited at concentrations attainable intravaginally; as were bacteria.
Conclusions Boric acid is fungistatic to fungicidal depending on concentration and temperature. Keywords Introduction Methods Table 1. PAN Pesticides Database - Boric acid - Identification, toxicity, use, water pollution potential, ecological toxicity and regulat. WIKIPEDIA - Boric acid. Boric acid, also called hydrogen borate, boracic acid, orthoboric acid and acidum boricum, is a weak, monobasic Lewis acid of boron often used as an antiseptic, insecticide, flame retardant, neutron absorber, or precursor to other chemical compounds. It has the chemical formula H3BO3 (sometimes written B(OH)3), and exists in the form of colorless crystals or a white powder that dissolves in water.
When occurring as a mineral, it is called sassolite. Occurrence Boric acid, or sassolite, is found natively in its free state in some volcanic districts, for example, in the Italian region of Tuscany, the Lipari Islands and the US state of Nevada. In these volcanic settings it issues, mixed with steam, from fissures in the ground. It is also found as a constituent of many naturally occurring minerals – borax, boracite, boronatrocaicite and colemanite. Preparation Na2B4O7·10H2O + 2 HCl → 4 B(OH)3 [or H3BO3] + 2 NaCl + 5 H2O BX3 + 3 H2O → B(OH)3 + 3 HX (X = Cl, Br, I) Properties NATIONAL TOXICOLOGY PROGRAM - OCT 1987 - TOXICOLOGY AND CARCINOGENESIS STUDIES OF BORIC ACID (CAS NO. 10043-35-3) IN B6C3Fi MICE.
J Clin Pathol. 1990 June; 43(6): 484–487. Bacteriostatic and bactericidal actions of boric acid against bacteria and fungi commo. NATIONAL PESTICIDE INFORATION CENTER - Boric acid technical fact sheet. Pesticide Biochemistry and Physiology 84, 1 (2006) 17-24 Boric acid toxicity to the German cockroach, Blattella germanica: Alter. EUROPE 10/02/99 Opinion on the safety of boric acid in medicinal products adopted on 10 February 1999. Question The Committee is asked the following three questions: Does the safety profile of boric acid support its use in parenteral medications intended for neonates ? Should the current contraindication for boric acid in the guideline on the excipients in the label and package leaflet of medicinal products for human use remain in its current form ? Does the safety profile and clinical experience of boric acid support the establishment of threshold dose levels below which the contraindication should not be labelled ?
Context of the question The question is asked in the frame of a "Guideline on the excipients in the label and package leaflet of medicinal products for human use" approved by the Pharmaceutical Committee which became applicable from 1st September 1997. According to this guideline, any medicinal product containing boric acid, its salts and esters is contraindicated for infants or young children up to 3 years old. Assessment. EPA – Boric acid. OMS - Boron in drinking-water. Effects on experimental animals and in vitro test systems Acute exposure The oral LD50 values for boric acid or borax in mice and rats are in the range of about 400–700 mg of boron per kg of body weight (Pfeiffer et al., 1945; Weir & Fisher, 1972).
Oral LD50 values in the range of 250–350 mg of boron per kg of body weight for boric acid or borax exposure have been reported for guinea-pigs, dogs, rabbits, and cats (Pfeiffer et al., 1945; Verbitskaya, 1975). Signs of acute toxicity for both borax and boric acid in animals given single large doses orally include depression, ataxia, convulsions, and death; kidney degeneration and testicular atrophy are also observed (Larsen, 1988).
Short-term exposure In a 13-week study, mice (10 per sex per dose) were fed diets containing boric acid at approximately 0, 34, 70, 141, 281, or 563 mg of boron per kg of body weight per day. Boric acid or borax was also fed to beagle dogs for 90 days or for 2 years. Long-term exposure Carcinogenicity. J. Econ. Entomol. 95(5): 1110Ð1112 (2002) Development of Granular Boric Acid Sugar Baits for House Flies (Diptera: Muscidae) J. Econ. Entomol. 96(5): 1559Ð1562 (2003) Boric Acid Bait Kills Adult Mosquitoes (Diptera: Culicidae) J Econ Entomol. 2004 Jun;97(3):1137-41. Influence of adding borax and modifying pH on effectiveness of food attractants for melo.