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Microb Drug Resist. 2016 Jun;22(4):342-6. Emergence of Carbapenemase-Producing Escherichia coli Isolated from Companion Animals in Algeria. Annals of Clinical Microbiology and Antimicrobials 06/04/16 Phenotypic and genotypic characteristics of carbapenem-resistant Enterobacteriaceae in a tertiary-level reference hospital in Turkey. CRE are increasingly isolated from community-acquired and nosocomial infections [6].

Annals of Clinical Microbiology and Antimicrobials 06/04/16 Phenotypic and genotypic characteristics of carbapenem-resistant Enterobacteriaceae in a tertiary-level reference hospital in Turkey

CRE can spread clonally from person to person or genes which encode carbapenemases can spread horizontally between isolates [2]. This is an important health concern because plasmid-encoded and easily transferable carbapenemases are involved [10]. The most important carbapenemases are KPC, VIM, NDM and OXA-48 [6]. CRE infections are highly mortal, and treatment options are narrow [7, 10]. Rapid identification of carbapenemase-producing strains is crucial for preventing hospital infections and outbreaks [7]. Certain risk factors were found to be related to the acquirement of CRE infections. The rate of CRE in our hospital during the study period was found as 2.82 %. The most common CRE species isolated in the US and European countries are K. pneumoniae followed by E. aerogenes and E. coli [2, 18].

Klebsiella pneumonia résistant au Carbapenem. AFSCA 24/02/17 Bactéries CPE dans la viande de porc. Des bactéries productrices de carbapénémases (CPE) ont été détectées dans le haché de porc en vente au détail en Belgique dans le cadre de la surveillance de l’antibiorésistance chez les bactéries indicatrices.

AFSCA 24/02/17 Bactéries CPE dans la viande de porc

L’information a été publiée dans un rapport récent de l’EFSA et de l’ECDC. L’utilisation de l’antibiotique carbapénème n’est pas autorisée chez les animaux de rente en Europe et donc en Belgique. Il pourrait s’agir d’une contamination croisée de la viande avec les bactéries CPE lors de la production, ou lors de la manipulation de la viande par un porteur des bactéries CPE. Dans le rapport publié la détection de CPE sur la viande ou animaux vivants en Europe est décrite comme très faible. Les contrôles effectués en Belgique dans le cadre de la surveillance obligatoire de la résistance aux antibiotiques chez les animaux de rente (échantillons prélevés en élevage et à l’abattoir) n’ont jusqu’à présent jamais permis de détecter des CPE à partir d’animaux vivants.

EUROSURVEILLANCE 09/02/17 Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014. L Dortet 1 2 3 4 , G Cuzon 1 2 3 4 , V Ponties 5 , P Nordmann 6 7 8 + Author affiliations Citation style for this article: Dortet L, Cuzon G, Ponties V, Nordmann P.

EUROSURVEILLANCE 09/02/17 Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014

Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014. Euro Surveill. 2017;22(6):pii=30461. Prevention & Infection Control via YOUTUBE 10/10/14 The Global Spread of Carbapenemases. ANTIMICROB. AGENTS CHEMOTHER 06/09/16 Carbapenem-Producing Enterobacteriaceae in Canada: Results from the Canadian Nosocomial Infection Surveillance Program, 2010-2014. JCM 06/01/16 The Problem of Carbapenemase Producing Carbapenem-Resistant Enterobacteriaceae Detection. REFLEXIONSIPC 09/06/16 Preventing carbapenem-resistant Salmonella or E.coli in foods. We welcome another guest post from Prof Peter Collignon (bio below) on the risk of antibiotic resistance in the food chain… Codex has recently announced they are doing more work on antimicrobial resistance.

REFLEXIONSIPC 09/06/16 Preventing carbapenem-resistant Salmonella or E.coli in foods

PLoS One. 2016; 11(1): Carbapenem-Resistant Bacteria Recovered from Faeces of Dairy Cattle in the High Plains Region of the USA. J Clin Microbiol. 2016 Mar;54(3):529-34. The Problem of Carbapenemase-Producing-Carbapenem-Resistant-Enterobacteriaceae Detection. PIGSITE 07/12/16 Resistance to Drug of Last Resort Found in Farm Animals in US (Carbapenem) News Resistance to Drug of Last Resort Found in Farm Animals in US 07 December 2016 US - Carbapenems are one of the most important classes of antibiotics used in humans, and are an important agent against multi-drug resistant bacteria.

PIGSITE 07/12/16 Resistance to Drug of Last Resort Found in Farm Animals in US (Carbapenem)

Now, for the first time, bacteria that carry a transmissible carbapenem resistance gene have been found in agricultural animals in the United States. The research is published in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology. CDC EID - Volume 22, Number 9—September 2016. Au sommaire notamment: Carbapenem-Resistant Enterobacter spp. in Retail Seafood Imported from Southeast Asia to Canada. Suggested citation for this article To the Editor: Carbapenems, antimicrobial drugs of last resort, are recommended only for severe community- and healthcare-associated multidrug-resistant bacterial infections.

CDC EID - Volume 22, Number 9—September 2016. Au sommaire notamment: Carbapenem-Resistant Enterobacter spp. in Retail Seafood Imported from Southeast Asia to Canada

In Canada, carbapenem-resistant infection rates in hospitals remained low (<0.25 cases/1,000 patient admissions) over 5 years’ (2009–2014) surveillance (1). Carbapenemase-producing bacteria have rarely been detected in the food chain in industrialized countries. However, carbapenemase genes were detected in bacteria isolated from produce in Switzerland (2) and seafood in Canada (3); implicated food items originated from Southeast Asia.

EUROSURVEILLANCE 23/06/16 Active surveillance scheme in three Romanian hospitals reveals a high prevalence and variety of carbapenamase-producing Gram-negative bacteria: a pilot study, December 2014 to May 2015. Introduction The worldwide emergence of carbapenemase-producing Gram-negative bacteria (CP-GNB) is widely accepted as a major public health threat that has caused international concern.

EUROSURVEILLANCE 23/06/16 Active surveillance scheme in three Romanian hospitals reveals a high prevalence and variety of carbapenamase-producing Gram-negative bacteria: a pilot study, December 2014 to May 2015.

The rapid spread of CP-GNB provides many challenges for healthcare systems, with implications that span from laboratory detection and infection control, to identifying suitable treatment options for organisms that are now starting to exhibit co-resistance to multiple last-resort antimicrobials [1]. EUROSURVEILLANCE 14/04/16 Carbapenem-resistant isolates of Acinetobacter baumannii in a municipal wastewater treatment plant, Croatia, 2014. , , , .

EUROSURVEILLANCE 14/04/16 Carbapenem-resistant isolates of Acinetobacter baumannii in a municipal wastewater treatment plant, Croatia, 2014

Virulence. ;():-. DOI: 10.4161/viru.19700 PMID: 22546906 Croatian Academy of Medical Sciences (CAMS). Antibiotic resistance in Croatia, 2012. Zagreb: CAMS; 2013:90-4. ECDC 14/04/16 ECDC rapid risk assessment: carbapenem-resistant Enterobacteriaceae (CRE) are a threat to patients and healthcare systems in EU/EEA Member States. ​The rapid spread of carbapenem-resistant Enterobacteriaceae (CRE) poses a significant threat to patients and healthcare systems in all EU/EEA Member States.

ECDC 14/04/16 ECDC rapid risk assessment: carbapenem-resistant Enterobacteriaceae (CRE) are a threat to patients and healthcare systems in EU/EEA Member States

CRE infections are associated with high mortality, primarily due to delays in administration of effective treatment and the limited availability of effective treatment options. New antibiotics capable of replacing carbapenems, a last-line group of antibiotics used to treat patients infected with multidrug-resistant bacteria, are not likely to become available in the near future. Furthermore, CRE are adapted to spread in healthcare settings as well as in the community. This ECDC risk assessment outlines the current and possible future risks for human health, the potential for spread both in healthcare settings and in the community, and cross-border aspects that must be taken into consideration both in EU/EEA Member States and in third countries.

Options for action addressing these areas are presented in the risk assessment. PHARMACEUTICA - 2015 - Emergence of Carbapenemase Producing Pathogens in Animals. MEDCRAVE 13/08/15 New Targets for Treatment, Prevention and Control of Carbapenem-Resistant A. baumannii Isolates Causing Nosocomial Infections. MBIO - JULY / AUGUST 2015 - Genomically Informed Surveillance for Carbapenem-Resistant Enterobacteriaceae in a Health Care System. Journal of Global Antimicrobial Resistance Volume 3, Issue 2, June 2015, Isolation of carbapenem-resistant Pseudomonas spp. from food.

PLOS 12/05/15 Carbapenemase producing bacteria in the food supply escaping detection. Abstract Carbapenem antimicrobials are critically important to human health and they are often the only remaining effective antibiotics for treating serious infections.

PLOS 12/05/15 Carbapenemase producing bacteria in the food supply escaping detection

Resistance to these drugs mediated by acquired carbapenemase enzymes is increasingly encountered in gram-negative bacteria and is considered a public health emergency. Animal origin food products are recognized as a potential source of resistant organisms, although carbapenem resistance has only recently been reported. In western countries there are active resistance surveillance programs targeting food animals and retail meat products. These programs primarily target beef, pork and poultry and focus exclusively on E. coli, Salmonella, Campylobacter spp. and Enterococcus spp.

Citation: Morrison BJ, Rubin JE (2015) Carbapenemase Producing Bacteria in the Food Supply Escaping Detection. Academic Editor: John Conly, University of Calgary, CANADA Received: December 10, 2014; Accepted: April 7, 2015; Published: May 12, 2015. J Antimicrob Chemother 18/12/14 Exploring the epidemiology of carbapenem-resistant Gram-negative - bacteria in west London and the utility of routinely collected hospital microbiology data. CDC EID - JUILLET 2014 - Carbapenemase-producing Organism in Food, 2014. Suggested citation for this article To the Editor: Carbapenem antimicrobial drugs are the line of defense against multidrug-resistant gram-negative bacterial infections.

The global emergence of carbapenemase-producing organisms is a public health emergency because these enzymes confer resistance to nearly all β-lactam drugs and are often associated with multidrug or pandrug resistance (1). Alarmingly, reports of carbapenemase-producing organisms from environmental and animal sources, including food animals, are increasing (1). Recently, clinical isolates of Salmonella enterica serotype Kentucky that produce VIM-2 and OXA-48 were reportedly isolated from patients in France with a travel history to Africa and the Middle East, suggesting foodborne transmission of carbapenemase producers (2).

Among other items, the squid was purchased from a Chinese grocery store in Saskatoon, Canada, in January 2014 as part of a drug-resistance surveillance pilot study. Acknowledgment References Table. ASPC - Rapport de surveillance sur résultats 2007 - 2013 - Les Entérobactéries résistant aux carbapénèmes (ERC) EUROSURVEILLANCE 12/11/15 Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries, May 2015. CDC EID – NOV 2015 – Au sommaire notamment: Carbapenem-Resistant Enterobacteriaceae in Children, United States, 1999–2012 ; Author affiliations: Rush University Medical Center, Chicago, Illinois, USA (L.K. Logan, R.A. Weinstein); John H. Stroger, Jr. Hospital of Cook County, Chicago (L.K.

Logan, R.A. Suggested citation for this article Abstract. PLOS 30/03/15 Carbapenem-Resistant Acinetobacter baumannii from Serbia: Revision of CarO Classification. Abstract Carbapenem-resistant A. baumannii present a significant therapeutic challenge for the treatment of nosocomial infections in many European countries. Although it is known that the gradient of A. baumannii prevalence increases from northern to southern Europe, this study provides the first data from Serbia.

Twenty-eight carbapenem-resistant A. baumannii clinical isolates were collected at a Serbian pediatric hospital during a 2-year period. The majority of isolates (67.68%) belonged to the sequence type Group 1, European clonal complex II. All isolates harbored intrinsic OXA-51 and AmpC cephalosporinase. Citation: Novovic K, Mihajlovic S, Vasiljevic Z, Filipic B, Begovic J, et al. (2015) Carbapenem-Resistant Acinetobacter baumannii from Serbia: Revision of CarO Classification. Academic Editor: Feng Gao, Tianjin University, CHINA Received: October 16, 2014; Accepted: February 23, 2015; Published: March 30, 2015. WIKIPEDIA - Carbapenem resistant enterobacteriaceae. Incidence and epidemiology[edit] According to the U.S. Centers for Disease Control, CRE was first detected in a North Carolina hospital in 2001.[4] Since that time, it has been identified in health care facilities in 41 other states. Studies showed that in 2012, 3% of patients in Chicago-area ICUs carried CRE.[1] The same data indicated a 30% infection rate in long-term care facilities (e.g. nursing homes), though not all patients are symptomatic.

Washington State Department of Health - MARS 2014 - Carbapenem-Resistant Enterobacteriaceae (CRE) MICHIGAN_GOV 06/03/14 Statewide Surveillance of Carbapenem-Resistant Enterobacteriaceae in Michigan. PIG PROGRESS 12/12/13 Pigs found to carry carbapenem-resistant bacteria. A novel type of antibiotic resistant bacteria has been causing worries in the German livestock industry. The bacteria, resistant to carbapenems, has been found in poultry and pigs. Carbapenems are usually considered to be last-line antibiotics for hospitalised patients suffering from severe microbial infections.

Until now, it used to be possible to combat resistant ESBL and MRSA bacteria by using carbapenems. Prof Dr Dick Mevius, Utrecht University, the Netherlands, recently expressed his worries about this development. The type of resistance is simply exchangeable between different types of bacteria. Recent publications in 2012 and 2013 by the German Federal Institute for Risk Assessment (BfR) pointed to the discovery of resistant E.coli at a pig farm and resistant Salmonella enterica at two finishing pig farms as well as a broiler farm.

Up until now, the problem of carbapenem resistance had only been a problem of humans, mostly by ignoring prudent use and unhygienic circumstances. Iranian Journal of Pharmaceutical Research (2013), 12 (3): 503-509 Carbapenem Restriction and its Effect on Bacterial Resistance in an Intensive Care unit of a Teaching Hospital. UNIVERSITY OF NEVADA 05/01/14 Thèse en ligne : Determining the Presence of Carbapenem Antibiotic Resistance in Clinical Isolates. Abstract Carbapenems are β-lactam antibiotics reserved for the treatment of severe microbial infections, especially those targeting the Enterobacteriaceae. Introduced in the 1980s, carbapenems have been used successfully in hospitals, and in the 1990s resistance was discovered. Carbapenem resistance is conferred through the production of carbapenemases.

In the U.S., the most common carbapenemase is Klebsiella pneumoniae carbapenemase (KPC). In 2012, the National Healthcare Safety Network reported a carbapenem resistance rate of 13.0% among Klebsiella pneumoniae infections, and indicated that the mortality rate associated with carbapenem resistant Enterobacteriaceae (CRE) infections ranged from 48.0-71.9%. Keywords Antibiotics, Beta lactam antibiotics, Drug resistance in microorganisms, Klebsiella pneumoniae Repository Citation. CDC EID - DEC 2013 - New Delhi Metallo-β-Lactamase-1 in Carbapenem-Resistant Salmonella Strain, China. CDC EID - OCT 2011 - Global Spread of Carbapenemaseproducing Enterobacteriaceae. CDC - 2012 - Guidance for Control of Carbapenem-resistant Enterobacteriaceae (CRE) Chemotherapy Research and Practice Volume 2014 (2014) Carbapenem Resistance among Enterobacter Species in a Tertiary Care Hospital in Central India. Jundishapur J Microbiol. 2014 November; 7(11) Detection of Metallo-Beta Lactamases Among Carbapenem-Resistant Pseudomonas aeruginosa.

1 Department of Microbiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran 2 Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran 3 Department of Biomolecular and Biochemistry, School of Veterinary Medicine, Shahid Chamran University, Ahvaz, IR Iran 4 Department of Genetic, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran 5 Nosocomial Infections Research Centre, Isfahan University of Medical Sciences, Isfahan, IR Iran 6 Department of Biostatistics and Epidemiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.

World J Gastrointest Endosc. Oct 16, 2014; 6(10): 457–474. Risk of transmission of carbapenem-resistant Enterobacteriaceae and related “superbugs” during gastrointestinal endoscopy. GIZMODO 12/06/14 Why the First Antibiotic-Resistant Superbug Found in Food Is a Big Deal. JOURNAL OF THE ASSOCIATION OF PHYSICIANS OF INDIA 19/01/10 New Delhi Metallo-b lactamase (NDM-1) in Enterobacteriaceae: Treatment options with Carbapenems Compromised. Payal Deshpande*, Camilla Rodrigues**, Anjali Shetty**, Farhad Kapadia***, Ashit Hedge***, Rajeev Soman*** *Dept of Research, **Dept of Lab Medicine, ***Dept of Medicine, P.D.Hinduja National Hospital & Medical Research Centre, Mumbai, India. Received: 14.12.2009; Revised: 18.01.2010; Accepted: 19.01.2010 Abstract Background : Carbapenems are among the few useful antibiotics against multidrug resistant gram negative bacteria particularly those with extended spectrum beta lactamase.

However resistance to carbapenems occurs and is mediated by mechanisms like loss of outer membrane proteins and production of beta lactamase that is capable of hydrolyzing carbapenems. Antimicrobial Resistance and Infection Control 2013, 2:6 The rise of carbapenem resistance in Europe: just the tip of the iceberg? NATURE 24/07/13 Antibiotic resistance: The last resort - Health officials are watching in horror as bacteria become resistant to powerful carbapenem antibiotics — one of the last drugs on the shelf.

As a rule, high-ranking public-health officials try to avoid apocalyptic descriptors. So it was worrying to hear Thomas Frieden and Sally Davies warn of a coming health “nightmare” and a “catastrophic threat” within a few days of each other in March. BFR 14/01/14 Antibiotics Resistance: Carbapenemase-producing germs in livestock populations. PARLEMENT EUROPEEN - Réponse à question E-000042-14 : Appearance of carbapenem-resistant Enterobacteria in the EU. Research has provided evidence of the possible threats posed by carbapenem-resistant nterobacteria (CRE) in humans and animals.

If spread on a large scale, the mortality rate caused by CRE is expected to be much higher than that resulting from Escherichia coli, breakouts of which occurred in 2007 and 2011. The most dangerous associated pathogen to have been identified is NDM-1, which is resistant to all antibiotics. PARLEMENT EUROPEEN - Réponse à question P-014429-13 Abuse of antibiotics in intensive rearing of fattening pigs. The European Food Safety Authority (EFSA) recently asked its Panel on Biological Hazards (BIOHAZ) to issue a scientific opinion on carbapenem resistance in food-producing animal ecosystems.

Carbapenem is an antibiotic that is normally used when other antibiotics are no longer effective, and it is therefore considered a last resort in the fight against harmful microorganisms. According to Regulation (EC) No 1831/2003, which prohibited the use of antibiotics as growth promoters, the use of carbapenem should be permitted only for therapeutic purposes. EFSA Journal 2013;11(12):3501 [70 pp.]. Scientific Opinion on Carbapenem resistance in food animal ecosystems. EFSA Journal 2013;11(12):3501 [70 pp.]. doi:10.2903/j.efsa.2013.3501.