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JAMDA - JUILLET 2009 - Probiotics and the Nursing Home : Should we give bacteria for breakfast? NATURE 11/09/06 Are Probiotics Effective for Treating Clostridium Difficile Disease and Antibiotic-Associated Diarrhea? Nature Clinical Practice Gastroenterology & Hepatology (2006) 3, 606-607doi:10.1038/ncpgasthep0627 Received 7 June 2006 | Accepted 18 August 2006 Mario Guslandi About the author Correspondence Hepatogastroenterology Unit, San Raffaele University Hospital, Via Olgettina 60, 20132 Milan, Italy Email guslandi.mario@hsr.it.

NATURE 11/09/06 Are Probiotics Effective for Treating Clostridium Difficile Disease and Antibiotic-Associated Diarrhea?

THE JOURNAL OF NUTRITION - 2007 - Prebiotics: The Concept Revisited. Testing methodologies If reliable and biologically meaningful data are to be collected on different prebiotics, rigorous testing of candidate molecules must be performed using standardized methodologies.

THE JOURNAL OF NUTRITION - 2007 - Prebiotics: The Concept Revisited

For each candidate prebiotic, these methodologies should demonstrate resistance to gastric acidity, hydrolysis by mammalian enzymes and gastrointestinal absorption, fermentation by intestinal microflora, and selective stimulation of growth and/or activity of intestinal bacteria. Nondigestibility: testing of prebiotic resistance to gastric acidity, hydrolysis by mammalian enzymes, and gastrointestinal absorption.

In vitro methods include determining resistance to acidic conditions and enzymatic (salivary, pancreatic, and small intestinal) hydrolysis (4–6). In vivo models are used to measure the recovery in feces of an oral dose given to germ-free rats or to rats pretreated with an antibiotic to suppress the intestinal flora (6). Fermentation by intestinal microflora. Inulin. Food safety and quality: Probiotiques. Les professionnels de la santé reconnaissent de plus en plus les effets bénéfiques, pour la santé et la nutrition humaines, des aliments auxquels des micro-organismes vivants (probiotiques) ont été ajoutés.

Food safety and quality: Probiotiques

De récents travaux scientifiques sur les propriétés et la fonctionnalité des micro-organismes dans les aliments donnent à penser que les probiotiques jouent un rôle important dans les fonctions immunologiques, digestives et respiratoires et qu’elles sont susceptibles d’aider à lutter contre les maladies infectieuses chez les enfants et d’autres groupes à risque élevé. Compte tenu de la popularité croissante des aliments probiotiques et du manque de consensus international sur une méthode permettant d’évaluer leur efficacité et leur sécurité, la FAO et l’OMS ont commencé à examiner les preuves scientifiques disponibles sur les aspects fonctionnels et les questions de sécurité sanitaire des probiotiques dans les denrées alimentaires. CSPI - Helpful bacteria - DEC 2006 - Should you take probiotics? UNIVERSITE DE MASSEY - 2005 - Thèse en lign eEnterococci in Milk Products. Global probiotics leader, Danone, has submitted a new disease reduction article 14 health claim linking consumption of its probiotic drinking yoghurt, Actimel, and diarrhoea, after withdrawing three article 13.5 immunity and digestive health claims in April.

UNIVERSITE DE MASSEY - 2005 - Thèse en lign eEnterococci in Milk Products

The new claim submitted to the European Food Safety Authority (EFSA) is centred on an independent, clinical trial published in June, 2007, in the British Medical Journal (BMJ), part-funded by Danone, that employed Actimel and demonstrated diarrhoea benefits. To see NutraIngredients.com coverage of that study click here . Danone vice president of external affairs and head of EU regulatory affairs, Patrick O'Quin, said Danone decided to pursue the diarrhoea claim because of the strength of the BMJ study, whose conclusions could only be pursued along the article 14 disease reduction path.

MEDICAL NEWS 29/06/07 Probiotic Drinks Can Help Reduce Diarrhoea Associated With Antibiotics. Probiotic. Élie Metchnikoff first suggested the possibility of colonizing the gut with beneficial flora in the early 20th century.

Probiotic

Probiotics are microorganisms that some have claimed provide health benefits when consumed.[1] The term probiotic is currently used to name ingested microorganisms associated with beneficial effects to humans and animals.[2] Introduction of the concept is generally attributed to Nobel Prize recipient Eli Metchnikoff, who in 1907 suggested that "the dependence of the intestinal microbes on the food makes it possible to adopt measures to modify the flora in our bodies and to replace the harmful microbes by useful microbes".[3] A significant expansion of the potential market for probiotics has led to higher requirements for scientific substantiation of putative beneficial effects conferred by the microorganisms. Etymology[edit] Definition[edit] Probiotics must have undergone controlled evaluation to document health benefits in the target host. History[edit] OMS - AVRIL 2002 - Guidelines for the Evaluation of Probiotics in Food.

PRNEWSWIRE 29/06/07 Danone Position Statement Re: BMJ Publication. LONDON, June 29 /PRNewswire/ -- - With Photo Danone welcomes the findings of the study published today in the British Medical Journal (29/06/07 - BMJ.com).

PRNEWSWIRE 29/06/07 Danone Position Statement Re: BMJ Publication

Dr Jean-Michel Antoine, science director at Danone, said: "There is already a host of clinical evidence that demonstrates the benefits of Actimel, however, Danone believes that the results of this trial are particularly significant. This study supports the fact that Actimel is scientifically proven to help support the body's natural defences. Danone would certainly support the researchers' observation that substantial savings could be made by the routine use of this specific probiotic. " He continued "The findings of this study are specific to Actimel and its unique strain Lactobacillus casei DN-114 001, and can't be extrapolated to other probiotic products".

Clostridium difficile Background Information Introduction What are the cost implications associated with Clostridium difficile? The American Society for Nutrition J. Nutr. 137:803S-811S, March 2007 Probiotics and Prebiotics: Effects on Diarrhea.