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URMC » People » Paul Spencer Brookes, Ph.D. Research Profile Journal Articles Paul Spencer Brookes, Ph.D. Contact Information
Collaborators Publications Fleming A, Noda T, Yoshimori T, Rubinsztein DC (2011) , “Chemical modulators of autophagy as biological probes and potential therapeutics.” Nat Chem Biol 7(1):9-17 Details Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, Imarisio S, Jahreiss L, Sarkar S, Futter M, Menzies FM, O'Kane CJ, Deretic V, Rubinsztein DC (2011) , “Lysosomal positioning coordinates cellular nutrient responses.”
Research José Viña was born in Valencia, Spain in 1953. After pursuing his studies in Medicine at the University of Valencia, and doing research work under the auspices of Prof Hans Krebs (Krebs cycle) in Oxford, he obtained his PhD in 1976. After teaching Physiology at Extremadura University (Spain) he returned to Valencia and took up his position as Professor of Physiology at the University of Valencia where he still works. Here Prof Viña combines his teaching duties with research work, the latter in two main lines: Ageing and exercise. José Viña leads a successful research group working on different aspects of oxidative stress with whom he has won numerous prizes for research work; he has published widely on glutathione, mitochondria, oxidative stress, free radicals and nutrition.
Professor Manuel Mayr MD PhD Professor of Cardiovascular Proteomics The James Black Centre King's College, University of London 125 Coldharbour Lane, London SE5 9NU, UK Phone: +44 (0) 20 7848 5132 Fax: +44 (0) 20 7848 5296 Biography Prof Manuel Mayr received his first degree in medicine from the University of Innsbruck, Austria, where he graduated “sub ausspiciis presidentis rei publicae”, the highest distinction awarded for academic education.
Research Interests For over thirty years, Professor Griffin's major research area has been geared towards understanding the biochemistry, molecular biology and physiology of a group of enzymes referred to as transglutaminases. This group of enzymes is commonly referred to as “protein biological glues” since it can crosslink proteins into stable, high molecular weight structures such as those found in skin, in fibrin cross linking during blood coagulation and in hair. Focus has been mostly on the tissue transglutaminase (TG2), and in particular, the importance of this enzyme in cell death, matrix deposition and cell adhesion and the relationship of these functions to wound healing, tissue fibrosis and scarring, tumour progression and cystic fibrosis.
The Cambridge SENS Foundation project. Regenerative medical therapies are ones that rebuild or repair the body, rather than trying to ‘reset’ its control systems (like drugs) or get rid of diseased bits (like surgery). Most regenerative medicine focuses on stem cells, but this is not the limit of the regenerative medicine idea. Our approach to regenerative medicine treats the body as a chemical system, and looks at where that has gone wrong and how we might ‘patch’ it to fix it.
Uncovering genes and small molecules that prolong lifespan through enhanced molecular stability Dr. Lithgow sheds light on the mechanisms of aging by identifying agents that extend lifespan or prevent age-related disease. He has discovered a range of factors that can lengthen life in the microscopic worm Caenorhabditis elegans , and he applies these findings to studies in human cell cultures. Much evidence points to stress contributing to a breakdown in the ability to maintain optimal molecular stability resulting in aging and disease. Certain life-extending agents help C. elegans respond to lifelong stress by remodeling the natural stress fighting cellular mechanisms, the Lithgow lab has found.
Home Innovative therapies The group is working with cells from the liver, skin, bone marrow, neuronal cells and stem cells (adult, fetal, embryonic). The clinical focus is on the development of systems for temporary liver support from outside the body and on growing human liver cells in bioreactors for progenitor cell transplantation. Clinical perspective We take a systems approach, to bridge basic sciences with technological and clinical disciplines.
The images in the top bar are (left to right): mandrill (by Malene Thyssen ), stained telomeres, DNA capillary sequencing, endothelial cells, 3D structure of the ras protein, roundworm, cell undergoing mitosis, and Charles Darwin. On the main image (again from left to right): a 3D plot of microarray data, a microarray, human embryonic stem cell colonies (by Nissim Benvenisty from PLoS ), and an agarose gel (by TransControl ), all over a DNA multiple alignment. Keywords: Ageing; Bioinformatics; Cell & Molecular Biology; Evolution; Genetics; Genome Analysis; Senescence; Systems Biology; Transcriptomics <p style="text-align:right;color:#A8A8A8"></p>
The garage is the paradigm for the Silicon Valley startup—think Apple or HP. However, real garages are not suitable for biology experiments. Biotech entrepreneurs have a much harder time moving from idea to prototype, which reduces the rate of innovation. To address this challenge, QB3 created two incubators that allow startups access to rental laboratory space close to UC faculty. These incubators, the QB3 Garage@UCSF and the QB3 Garage@Berkeley, are the biotech equivalent of garages: small spaces for entrepreneurs to lay the foundations for companies that may spearhead new industries.
For almost two decades, Cambia has created new biological enabling technologies, distributed, and supported these technologies globally. In 2005, we launched BioForge.net as a experimental prototype for online collaborations to improve and extend our technologies under BiOS licensing schemes. In 2008, BioForge as a web facility was re-integrated into CambiaLabs. Unfortunately, the forum discussions are no longer available.
Regenerative Medicine, Tissue Engineering and associated disciplines at Imperial College span many Departments in the Faculties of Medicine, Natural Science and Engineering. The Tissue Engineering and Regenerative Medicine Centre (TERM) based at Chelsea and Westminster Hospital was Imperial’s first example of a collaborative enterprise between translational biological research and Material science to stimulate new paradigms in tissue engineering. This was the pioneering enterprise of Dame Julia Polak who, although officially retired, is still active as an Emeritus Professor and has recently been elected to the Steering Committee of the UK Stem Cell Collaboration.
An International Leader in Regenerative Medicine The Wake Forest Institute for Regenerative Medicine (WFIRM) is a leader in translating scientific discovery into clinical therapies. Physicians and scientists at WFIRM were the first in the world to engineer laboratory-grown organs that were successfully implanted into humans. Today, this interdisciplinary team is working to engineer more than 30 different replacement tissues and organs and to develop healing cell therapies-all with the goal to cure, rather than merely treat, disease.
The Centre for Synthetic Biology and Innovation (CSynBI) is developing the foundational tools for synthetic biology and using these to generate innovative biological applications for cutting-edge research, healthcare and industry. Along with our research and development of synthetic biology we also integrate our science with emerging ethical, legal and societal issues to responsibly mature this powerful new technology. The research laboratories of CSynBI opened in April 2010 and have already produced many exciting publications in synthetic biology.
Founded in 1973, the Foundation for Liver Research (formerly called the Liver Research Trust) has supported research programmes into liver disease for more than thirty years including much of the early pioneering work at King’s College Hospital into liver transplantation and acute liver failure. Professor Roger Williams, CBE, has been the Director of Research since 1973 and continues in that role. In 1997 the Foundation established an Institute of Hepatology at University College London under the continuing direction of Professor Williams, in a purpose-designed three storey new building of just under 7000 square feet. In 2000 the Foundation purchased premises immediately behind the Institute in Huntley Street which have been refurbished as rental accommodation for students and essential workers and which will also provide much needed meeting and common room facilities for the research staff.