background preloader

Uni Science

Facebook Twitter

Human Telomerase and Its Regulation. The telomere is a special functional complex at the end of linear eukaryotic chromosomes, consisting of tandem repeat DNA sequences and associated proteins.

Human Telomerase and Its Regulation

It is essential for maintaining the integrity and stability of linear eukaryotic genomes. Telomere length regulation and maintenance contribute to normal human cellular aging and human diseases. The synthesis of telomeres is mainly achieved by the cellular reverse transcriptase telomerase, an RNA-dependent DNA polymerase that adds telomeric DNA to telomeres. Expression of telomerase is usually required for cell immortalization and long-term tumor growth. In humans, telomerase activity is tightly regulated during development and oncogenesis.

Molecular characterization using DNA markers / Conserving diversity / Innehåll / Farm Animals / NordGens webbplats - Nordic Genetic Resource Center. DNA studies shed light on relationships and diversity among animal breeds.

Molecular characterization using DNA markers / Conserving diversity / Innehåll / Farm Animals / NordGens webbplats - Nordic Genetic Resource Center

The extent and nature of genetic diversity of Nordic and Baltic farm animals has been investigated by typing DNA markers in a set of individuals belonging to several breeds. To date, cattle, sheep, horse and poultry breeds have been studied and research on goat breeds was initiated in 2011. The most useful markers for these studies have been microsatellites, from sire to son inherited Y-chromosome’s markers and from dam to daughter and son inherited mitochondrial DNA. In addition, the structure and action of important genes have been analyzed. Textbook of pediatric infectious diseases.