Could a male fertility pill adversely affect inhibition via allopregnanolone levels? - sci.med.prostate.bph. Seriphos Experience? Female First Forum • View topic - is atypical depression caused by PEA deficit? L-deprenyl (DPR) is a drug developed in the 1960s by Dr. Joseph Knoll. Research has shown DPR to be a safe and multi-faceted drug. At doses of 10-15mg/day or less for humans, DPR is a selective MAO-B inhibitor.
MAO-A enzymes break down 5-HT and NA, while MAO-B enzymes break down DA and phenylethylamine (PEA). Classic MAOIs, such as phenelzine and tranylcypromine, inhibit both MAO-A and MAO-B. In 1980 Mendelwicz and Youdin reported results from a double-blind study comparing placebo, 300mg 5HTP, and 5HTP plus DPR. Quitkin and co-workers found DPR to be superior to placebo in a 6 week trial with 17 atypical depressive patients, and relatively free of side effects. 9/10 positive DPR responders required a 30mg/day DPR dosage. J. Based on a double blind, crossover study of placebo vs. 3 weeks of DPR at 60mg/day dosage, T.
All of the preceding studies were relatively short-term, typically 3 to 6 weeks. In 1984 W. In 1991 H.C. Love and Fear. Sociopaths and Aspies - Autism Politics, Activism, and Media Representation. If you lacked the ability to feel remorse that could put you in the category. The lack of fear is what allows some to engage in the psychopathic behavior that is stereotyped with psychopaths. Testosterone is linked to muscle mass, aggression, and psychopathy also. Fear levels and empathy levels are reduced in those with high testosterone levels, statistically. Interestingly when a child is born in a family the father's testosterone levels will naturally reduce to enhance the nuturing aspects that come with greater levels of empathy and lower levels of testosterone.
Oxytocin levels normally rise. Not to say here that high levels of testosterone cause psychopathy, but you won't see too many non-aggressive individuals on front line combat that can control their empathy and fear well enough to kill another human being. Of course, it's not psychopathic behavior to kill in combat because it is accepted within society; pride is often felt rather than remorse. What about dopamine/prolatin in multiorgasmic women? Narcissistic Personality Disorder (NPD) : Traits discussed. Almost everyone has some narcissistic traits, but being conceited, argumentative, or selfish sometimes (or even all the time) doesn't amount to a personality disorder.
Narcissistic Personality Disorder is a long-term pattern of abnormal thinking, feeling, and behavior in many different situations. The traits on this page will seem peculiar or disturbing when someone acts this way -- i.e., you will know that something is not right, and contact with narcissists may make you feel bad about yourself. It's not unusual for narcissists to be outstanding in their field of work. But these are the successful people who have a history of alienating colleagues, co-workers, employees, students, clients, and customers -- people go away mad or sad after close contact with narcissists. How many narcissists does it take to change a light bulb?
(a) Just one -- but he has to wait for the whole world to revolve around him. The most telling thing that narcissists do is contradict themselves. Oxytocin release and social drugs [Archive] I was poking around google scholar trying to learn about MDMA and its relationship to oxytocin release when I found this interesting little article: The test subjects are just rats of course, but they observe increased social interaction after MDMA administration and then a similar increase in social interation after the administration of another oxytocin releaser, 8-HO-DAPT.
The article suggests that for these compounds 5-HT1a agonism is the route to oxytocin release. This got me thinking about this compound and other similar ones being used as social drugs, both recreationally and for utility to deal with shyness, etc. Does anyone know of this kind of thing being done, or perhaps have thoughts to share on the matter? Here's the abstract from the article if you don't want to go to the link.
COMT Inhibitor Synergy. Careful with COMT inhibitors. You don't want to get too much dopamine going through the MAO pathway or else you may build up the DOPAL intermediary which can be neurotoxic if alcohol dehydrogenase can't get to it fast enough. Here's the study that talks about MAO degrading dopamine into DOPAL and then the non-neurotoxic DOPAC via alcohol dehydrogenase: Quote Chem Biol Interact. 2011 Jun 30;192(1-2):118-21. Epub 2011 Jan 13.Dopamine-derived biological reactive intermediates and protein modifications: Implications for Parkinson's disease.Jinsmaa Y, Florang VR, Rees JN, Mexas LM, Eckert LL, Allen EM, Anderson DG, Doorn JA.SourceDivision of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242-1112, USA.AbstractDopamine (DA) undergoes monoamine oxidase catalyzed oxidative deamination to 3,4-dihydroxyphenylacetaldehyde (DOPAL), which is metabolized primarily to 3,4-dihydroxyphenylacetic acid (DOPAC) via aldehyde dehydrogenase (ALDH).
5-HT1A Pre-synaptic and Post-synaptic Neuromodulation -> Novel antidepressants. [Archive] Some novel serotonergic compounds: Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B. RATIONALE: The delay in onset and treatment resistance of subpopulations of depressed patients to conventional serotonin reuptake inhibitors has lead to new drug development strategies to produce agents with improved antidepressant efficacy. OBJECTIVES: We report the in vivo characterization of the novel 5-HT(1A/1B) autoreceptor antagonist/5-HT transporter inhibitor (6-[(1-{2-[(2-methyl-5-quinolinyl)oxy]ethyl}-4-piperidinyl)methyl]-2H-1,4- benzoxazin-3(4H)-one), SB-649915-B. Lu AA21004: a novel potential treatment for mood disorders. In vitro binding affinities and functional activities were determined in membranes and whole cells expressing cloned receptors and transporters.
Phase of Development: Phase II. Serotonin receptors involved in vasopressi... [J Neuroendocrinol. 2003. 5-HT2A Receptors Stimulate ACTH, Corticosterone, Oxytocin, Renin, and Prolactin Release and Activate Hypothalamic CRF and Oxytocin-Expressing Cells. Louis D. Van de Kar1,2, Adil Javed1,3, Yahong Zhang1,2, Florence Serres1,2, Danı́ K. Raap1,2, and Thackery S. Gray1,3 +Show Affiliations The Journal of Neuroscience, 15 May 2001, 21(10): 3572-3579; Abstract The 5-HT2A/2C agonist (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI) stimulates hypothalamic neurons to increase the secretion of several hormones. Dysfunction of serotonergic neurons is associated with neuropsychiatric disorders such as depression, anxiety, and premenstrual syndrome (Joffe and Cohen, 1998; Lucki, 1998).
The neuroendocrine responses to serotonergic activation have been used as a diagnostic tool to examine the functioning of serotonergic neurons in the brains of patients suffering from mood disorders (Cowen, 1998). Fos, the protein product of the immediate early gene c-fos, is considered a reliable marker of synaptic activation (Hoffman et al., 1993; Luckman, 1995). Animals. Drugs. Experiment 1: neuroendocrine challenge tests. Immunocytochemistry.