Sator_arepo: Давно не даёт покоя термин click reacti. Ratamaque: Научное, click chemistry. Click Chemistry: Diverse Chemical Function from a Few Good Reactions - Kolb - 2001 - Angewandte Chemie International Edition. A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes - Rostovtsev - 2002 - Angewandte Chemie International Edition. Drug Discovery Today - Drug Discovery Today Citation Classic: The growing impact of click chemistry on drug discovery. Since its publication in December 2003, to the time of writing this article in August 2009, it has been cited some 527 times and has never been out of our quarterly top 25 most downloaded articles. In a nutshell, Click chemistry is a highly reliable modular approach utilising the most efficient and reliable chemical transformations. It has found wide utility throughout drug discovery, but has probably found most benefit with medicinal chemists in hit and lead generation through combinatorial and target-templated in situ chemistry, as well as in proteomics and DNA research, through the use of bioconjugation reactions.
The approach is best illustrated by the linking reaction involving copper-(I)-catalyzed 1,2,3-triazole formation from azides and terminal acetylenes. This reaction is particularly powerful as a result of its high dependability, complete specificity and the bio-compatibility of the reactants. Drug Discovery Today Citation Classic.