Zentralblatt-math. Lifes First Spark Re-Created in the Laboratory. New-Findings-Challenge-Assumptions-about-Origins-of-Life. Origin of amino acid homochirality: Relationship with the RNA world and origin of tRNA aminoacylation. Abstract The origin of homochirality of l-amino acids has long been a mystery. Aminoacylation of tRNA might have provided chiral selectivity, since it is the first process encountered by amino acids and RNA. An RNA minihelix (progenitor of the modern tRNA) was aminoacylated by an aminoacyl phosphate oligonucleotide that exhibited a clear preference for l- as opposed to d-amino acids. A mirror-image RNA system with l-ribose exhibited the opposite selectivity, i.e., it exhibited an apparent preference for the d-amino acid. The selectivity for l-amino acids is based on the stereochemistry of RNA. Keywords Homochirality; Amino acids; tRNA; RNA world; Minihelix; Aminoacylation; Stereochemistry; Origin of life Copyright © 2008 Elsevier Ireland Ltd.
RNA World 3%.avi. RNA world<span class='subt'>en</span> on The Tweeted Times. RNA World. A molecular model for the origin of protein translation in an RNA world. Abstract The RNA world hypothesis requires a ribozyme that was an RNA-directed RNA polymerase (ribopolymerase). A model for this, based on the core of the large subunit of the ribosome, is developed further. The geometry of a potential active site for this ribopolymerase suggests that it contained a cavity (now occupied by the aminoacyl-tRNA) and that an amino acid binding in this might have “poisoned” the ribopolymerase by cross-reacting with the nucleoside triphosphate before polymerization could occur. Based on a similarity to the active site components of the class-I tRNA synthetase enzymes it is proposed that the amino acid could become attached to the nascent RNA transcript producing a variety of amino-acylated tRNA-like products.
Keywords RNA world; Ribosome; Translation; Genetic code Copyright © 2006 Elsevier Ltd. The RNomics-RNA World #Paper. Project: Laboratory Studies of the Origins of an RNA World « CUB « 2004 « Annual Reports « Library of Resources « NAI « NASA Astrobiology. RNA world<span class='subt'>en</span> on The Tweeted Times. An Error Occurred Setting Your User Cookie. RNA world<span class='subt'>en</span> on The Tweeted Times. Project: Initiation of an RNA world « CUB « 2003 « Annual Reports « Library of Resources « NAI « NASA Astrobiology.
Project: Laboratory Studies of the Origins of an RNA World « CUB « 2004 « Annual Reports « Library of Resources « NAI « NASA Astrobiology. Project: From Proto-Metabolism to the RNA World « CUB « 2007 « Annual Reports « Library of Resources « NAI « NASA Astrobiology. RNA World (2) 3%.avi. Elsevier. Carcinogenesis is regarded as a mutagenesis, a process of continuous generation of mutations in a cancerous cell.
The basis of this process contains a carcinogenic hyper-cycle as one of the forms of the RNA world progress. On the one side, this hyper-cycle ensures self-reproduction, on the other side, generation of mutations of DNA oligo-nucleotides, which, on its part, leads to its re-programming and a cancerous transformation of the cell. Carcinogenic hyper-cycle is generated at the beginning as an autonomous process of RNA replication in the cytoplasm of a cell which has stopped the cooperation with the DNA replication.
Under influence of different factors, it gets the ability for concurrence with the DNA replication, becomes a new organizer of the order in the cell, and gradually supersedes and represses the latter one (DNA replication). Cancer as a carcinogenic hyper-cycle and a RN... [Med Hypotheses. 2013. The coevolutionary roots of bioch... [J Mol Microbiol Biotechnol. 2013. Exploring the RNA world in hematopoietic cells through the lens of RNA-binding proteins - Yuan - 2013 - Immunological Reviews. An RNA World under Hydrothermal Environments as the Basis. PNAs targeting the RNA world micro RNA next. Origin of life emerged from cell membrane bioenergetics. A coherent pathway which starts from no more than rocks, water and carbon dioxide and leads to the emergence of the strange bio-energetic properties of living cells, has been traced for the first time in a major hypothesis paper in Cell this week.
At the origin of life the first protocells must have needed a vast amount of energy to drive their metabolism and replication, as enzymes that catalyse very specific reactions were yet to evolve. Most energy flux must have simply dissipated without use. So where did it all that energy come from on the early Earth, and how did it get focused into driving the organic chemistry required for life? The answer lies in the chemistry of deep-sea hydrothermal vents. In their paper Nick Lane (UCL, Genetics, Evolution and Environment) and Bill Martin (University of Dusseldorf) address the question of where all this energy came from - and why all life as we know it conserves energy in the peculiar form of ion gradients across membranes. The non-coding RNA world of the bacterial pathogen ... [RNA Biol. 2012.
Molecular biology: Circles reshape the RNA world. [Nature. 2013. DRIVER Document. Molecular biology: Circles reshape the RNA world. British Library Direct: Order Details. British Library Direct: Order Details. The (Noncoding) RNA World. [Nucleic Acid Ther. 2013. British Library Direct: Order Details. Forskningsdatabasen.dk. Search in more than 500.000 records from all Danish universities and a number of Danish research institutions. more document types Search tips You can make more precise and/or complex search queries by using DDFs prefixes and search operators – get tips on how to make your searches better below. A combination of search terms, e.g. Water Technical University will return records that have all words present somewhere in their data (metadata). Use “” quotations for a precise search – for instance if you want to look up a specific title. Use = as an OR search making it possible to combine AND / OR queries, e.g.
Use ? Use prefixes to search in specific bibliographic elements e.g.: TI:university will return records that has the word “university” in the title. Search codes To search for words in specific parts for the records, i.e. titel. author etc. please use the prefixes like this TI:"the diffusion of innovation" using the "" to search for a specific title. Search for Use prefix Note Author Title Code db. A new era for the RNA world. Non-Coding RNA Genes and the Modern RNA World. British Library Direct: Order Details.
British Library Direct: Order Details. The RNA–Protein World. The RNA-Protein World. [RNA. 2013. British Library Direct: Order Details. Exploring the RNA world in hematopoietic cells through the lens of RNA-binding proteins - Yuan - 2013 - Immunological Reviews. The "Strong" RNA World Hypothesis: Fifty Years Old. Footprints of a trypanosomatid RNA wor... [Mem Inst Oswaldo Cruz. 2012. Exploring the RNA world in hematopoietic cells t... [Immunol Rev. 2013. The "Strong" RNA World Hypothesis: Fifty Years ... [Astrobiology. 2013. British Library Direct: Order Details. Molecular biology: Circles reshape the RNA world. [Nature. 2013. Molecular biology: Circles reshape the RNA world. Ageing Research Reviews - Ageing and the small, non-coding RNA world. Volume 12, Issue 1, January 2013, Pages 429–435 Special Issue: Invertebrate Models of Aging Edited By Mark Wilson, Sige Zou and Mark P Mattson Review Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA Received 16 December 2011 Revised 12 March 2012 Accepted 29 March 2012 Available online 6 April 2012 Choose an option to locate/access this article: Check if you have access through your login credentials or your institution Check access Abstract MicroRNAs, a class of small, non-coding RNAs, are now widely known for their importance in many aspects of biology.
Highlights Keywords Aging; MicroRNA; Small non-coding RNA; RNA editing; C. elegans Figures and tables from this article: Fig. 2. A novel non-coding RNA role for tRNA-derived RNA fragments: A specific ribonuclease cleaves tRNA transcripts in response to stress (e.g. heat or oxidative stress), producing a nearly half-sized tRNA fragments (half-tRNAs). Fig. 3. Copyright © 2012 Elsevier B.V. Biochimie - Coenzymes, viruses and the RNA world. Abstract The results of a detailed bioinformatic search for ribonucleotidyl coenzyme biosynthetic sequences in DNA- and RNA viral genomes are presented. No RNA viral genome sequence available as of April 2011 appears to encode for sequences involved in coenzyme biosynthesis. In both single- and double-stranded DNA viruses a diverse array of coenzyme biosynthetic genes has been identified, but none of the viral genomes examined here encodes for a complete pathway.
Although our conclusions may be constrained by the unexplored diversity of viral genomes and the biases in the construction of viral genome databases, our results do not support the possibility that RNA viruses are direct holdovers from an ancient RNA/protein world. Extrapolation of our results to evolutionary epochs prior to the emergence of DNA genomes suggest that during those early stages living entities may have depended on discontinuous genetic systems consisting of multiple small-size RNA sequences. Highlights Keywords. The RNA worlds in context. The RNomics #Paper Daily. PipelineReview.com - Biotech News & Online Store - Home. Astrobiology: Life in the Universe. Close Entire Site NAI ASTEP ASTID Exobiology Login Go! HOME NAI ASTEP ASTID Exobiology NASA: National Aeronautics and Space Administration Astrobiology: Life in the Universe nai You are here: NASA Astrobiology Institute » Reports » Annual Reports » 2006 » University of Colorado, Boulder » From Proto-Metabolism to the RNA World Articles About this Site About Astrobiology Astrobiology in Missions Roadmap Ask an Astrobiologist 2006 Annual Report University of Colorado, Boulder Reporting | JUL 2005 – JUN 2006 From Proto-Metabolism to the RNA World Project Summary View smaller map View: Field Sites | Collaborators View smaller map View: Field Sites | Collaborators ( known locations of 2) 4 Institutions 3 Teams 0 Publications Field Site View larger map View: Field Sites | Collaborators 10000 km Leaflet | © OpenStreetMap contributors View larger map View: Field Sites | Collaborators ( known locations of 2) Download Project Report This Project Report is also available to download as a PDF.
Project Progress Publications. Computational biology of RNA interactions - Dieterich - 2012 - Wiley Interdisciplinary Reviews: RNA. Stability Studies on Random Folded RNAs (‘Never Born RNAs’), Implications for the RNA World - Anella - 2011 - Chemistry & Biodiversity. Home - Springer. 1211.0413. Project: From Proto-Metabolism to the RNA World « CUB « 2006 « Annual Reports « Library of Resources « NAI « NASA Astrobiology. The Tweeted Times - personal newspaper generated from your Twitter account. Astrobiology: Life in the Universe. Project: Initiation of an RNA world « CUB « 2003 « Annual Reports « Library of Resources « NAI « NASA Astrobiology. Whence Flavins? Redox-Active Ribonucleotides Link Metabolism and Genome Repair to the RNA World - Accounts of Chemical Research. Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850, United States Acc.
Chem. Res., 2012, 45 (12), pp 2151–2159 DOI: 10.1021/ar300222j Publication Date (Web): October 10, 2012 Copyright © 2012 American Chemical Society Biography Khiem Van Nguyen was raised in Vietnam and received his B.S. degree in Chemistry from Hanoi National University in 2005. Cynthia J. Section: Abstract Present-day organisms are under constant environmental stress that damages bases in DNA, leading to mutations. Photolyase is a widespread and phylogenetically ancient enzyme that utilizes longer wavelength light to cleave thymine dimers in DNA produced via photodamage.
Citing Articles View all 3 citing articles Citation data is made available by participants in CrossRef's Cited-by Linking service. This article has been cited by 1 ACS Journal articles (1 most recent appear below). Coenzymes, viruses and the RNA world. [Biochimie. 2012. The origins of the RNA world. [Cold Spring Harb Perspect Biol. 2012. Primordial soup or vinaigrette: did the RNA worl... [Biol Direct. 2012.
Landes Bioscience Journals: RNA Biology. "Hypothesis for the modern RNA world":... [Orig Life Evol Biosph. 2011. Progress in studies on the RNA world. [Orig Life Evol Biosph. 2011. Primordial ocean chemistry and its com... [Orig Life Evol Biosph. 2011. Aptamers and the RNA world, p... [Cold Spring Harb Perspect Biol. 2012.