background preloader

Personalised Medicine

Facebook Twitter

Melbourne Genomics Health Alliance. Rare Cancers Australia - Genomic Testing Blueprint. Home. Macquarie University - GenIMPACT: Centre for Economic Impacts of Genomic Medicine. GenIMPACT: Centre for Economic Impacts of Genomic Medicine focuses primarily on the potential of genomics and similarly path-breaking new innovations that improve human health, where these advances have significant impacts on the economy and society.

Macquarie University - GenIMPACT: Centre for Economic Impacts of Genomic Medicine

The impacts not only have the potential to transform individual lives but also have marked impacts across multiple Federal and State government portfolios addressing health, economic, and social policy priorities as well as the economy. Stem cell and genetic engineering - Cell Therapies. Scale Down and Scale Up: How to Mass Customize Personalized Care. Photo by Gerhard Bögner | Pixabay Helen Bevan is Chief Transformation Officer, NHS Horizons England, and known around the globe for her efforts to build learning networks to energize large-scale change in health and care.

Scale Down and Scale Up: How to Mass Customize Personalized Care

In the following interview, she addresses the challenge of providing personalized care for individuals (scaling down) while also improving care or health for a large population (scaling up). Bevan will share more on this topic at the IHI/BMJ International Forum on Quality and Safety in Healthcare: Asia Pacific in Taipei (September 18–20, 2019). What does it mean to scale down and scale up in health care improvement?

I’ll start with an example from my own country in the National Health Service in England. There’s a tension at the heart of the plan because, on the one hand, it talks about how we’ll create personalized and individualized care and support for people that is based on what matters to patients. Alipogene tiparvovec. Gene therapy using an AAV vector. A new gene is inserted into a cell using the AAV protein shell. Once inside the nucleus, the new gene makes functional protein to treat a disease. Alipogene tiparvovec (marketed under the trade name Glybera) is a gene therapy treatment designed to reverse lipoprotein lipase deficiency (LPLD), a rare inherited disorder which can cause severe pancreatitis.[1] In July 2012, the European Medicines Agency recommended it for approval (the first recommendation for a gene therapy treatment in either Europe or the United States), and the recommendation was endorsed by the European Commission in November 2012.[2][3] The drug is administered via a series of injections into the leg muscles—as many as 60, all in one session.[4] It is a one-time treatment intended to last at least ten years.

History[edit] GeneTherapy.ISTH.org - Gene Therapy in Hemophilia: An ISTH Education Initiative. Big Data for Precision Medicine. The electronic patient health record (EHR) is a source of big data containing information regarding socio-demographics, medical conditions, genetics, and treatments; yet the human ability to process this data without effective decision support is finite.

Big Data for Precision Medicine

For healthcare, the goal is to provide a continually learning infrastructure with real-time knowledge production and to develop a system that is preventative, predictive, and participatory [2]. In order to achieve this goal, computer models are required to help clinicians organize the data, recognize patterns, interpret results, and set thresholds for actions.

Examples of big data analytics for new knowledge generation, improved clinical care, and streamlined public health surveillance are already apparent. For example, the EHR has been successfully mined for post-market surveillance of medications and improved pharmacovigilance. In the United Kingdom, the National Health Service intends to be paperless by 2018. Science of mitochondrial donation and related matters. Global Organisation for Bioinformatics Learning, Education & Training. The Undergraduate Training in Genomics (UTRIG) Initiative: early & active training for physicians in the genomic medicine era. About Us — Precision Medicine Advisors. Jeanette McCarthy, MPH, PhD is a UC Berkeley trained genetic epidemiologist and spent the early part of her career in industry at Millennium Pharmaceuticals before transitioning to academia.

About Us — Precision Medicine Advisors

She currently holds adjunct faculty positions at UCSF and Duke University. Her previous research had focused on the genetic underpinnings of complex diseases, both infectious and chronic. More recently, she has become a leading educator in the field of genomic and precision medicine. Jeanette helped launch the first consumer-facing magazine in this field, Genome, and served as Editor-in-Chief from 2014-2016. She developed the first MOOC on precision medicine, offered through Coursera, and teaches at UCSF and UC Berkeley Extension as well. OMIM - Online Mendelian Inheritance in Man. European Society of Human Genetics: News. For immediate release: Thursday 16 March 2017 A Bill that would allow companies to require employees to undergo genetic testing and disclose the results to their employers, or risk having to make health insurance payments of thousands of dollars extra, was recently approved by the US House of Representatives Committee on Education and the Workforce, with all 22 Republicans supporting it and all 17 Democrats opposing.

European Society of Human Genetics: News

Genetic tests can predict health risks. In the US, where companies cover significant parts of the health insurance of their employees they may, understandably, want to minimise these risks. In the past, however, decisions on whether or not to undergo genetic testing have been the voluntary choices of individuals. GC-CANCRSC Graduate Certificate in Cancer Sciences - 2017. The Centre for Genetics Education — Centre for Genetics Education. GetSharedSiteSession?rc=4&redirect= To view the full text, please login as a subscribed user or purchase a subscription.

getSharedSiteSession?rc=4&redirect=

Click here to view the full text on ScienceDirect. Fig. 1 Schematic overview of the INFORM workflow and timelines. The mean time intervals are given on top of the boxes, followed by the median time needed for each step and the range with minimal and maximal values (indicated by square brackets). Tartu Ülikooli Eesti geenivaramu. Theconversation. Our Test. You are unique, your medication should be too Your unique genetic profile determines how your body processes certain medications.

Our Test

Chemmart agrees to improve its promotion of “myDNA” tests. The Australian Competition and Consumer Commission has accepted an administrative undertaking on behalf of Chemmart in relation to representations regarding the effectiveness of a myDNA genetic test in identifying an individual’s response to certain drugs.

Chemmart agrees to improve its promotion of “myDNA” tests

The ACCC was concerned that statements in Chemmart’s catalogues, television infomercials, in-store brochures and other promotional materials about the myDNA test risked conveying a false or misleading impression regarding the usefulness of the genetic test, and the consumers for whom it may be appropriate. A person’s genetic profile is just one of a wide range of factors that may be considered by a medical practitioner in determining the type and dose of drug that is suitable for an individual.

“Consumers place a high level of trust in pharmacists and the information they provide. Chemmart withdrew all of the promotional materials containing the statements of concern to the ACCC following contact by the ACCC. The National Academies Press. 'Customized Care' MyDNA. Fulfilling the Promise of Personalized Medicine? Systematic Review and Field Synopsis of Pharmacogenetic Studies. Abstract Background.

Fulfilling the Promise of Personalized Medicine? Systematic Review and Field Synopsis of Pharmacogenetic Studies

Precision Medicine Is A Needed Goal That Will Benefit Cancer Patients. Since last month’s post on precision medicine in oncology, Americans continue to worry about prescription drug costs, a poll confirmed.

Precision Medicine Is A Needed Goal That Will Benefit Cancer Patients

Most cancer meds approved by the FDA in recent years don’t extend life but do cost more, a JAMA study found. These indicators – along with news that “miracle” drugs remain unlikely to be truly miraculous – take us back to the question of whether precision medicine is a valid goal. Today an oncologist-policy-maker-and-medical-ethicist reminds us that, in effect, we’re all paying for the sky-high price of new drugs. Which begs the question, if patients – or society – can’t afford the cancer treatments we’ve already got, why search for new ones?

My bottom line: Precision medicine will help cancer patients. Database Access - UNSW Library. NUS Engineering team develops novel technology to “print” customised tablets for personalised medicine. A team of researchers from the National University of Singapore (NUS) have found a way to make personalised medicine cheaper and easier. Imagine if you could combine the myriad of pills you need to take for your ailment in just one tablet; or if you need only to take the medication once a day and the drug will be slowly released throughout the day at different rates to treat your illness; or if doctors could easily make tablets on the spot that are tailored to each patient’s needs. All these could become a reality with a new method of tablet fabrication designed by Assistant Professor Soh Siow Ling and PhD student Ms. Sun Yajuan from the Department of Chemical and Biomolecular Engineering at the NUS Faculty of Engineering.

The novel system can make customisable pills that release drugs with any desired release profiles. Untitled. As we find out more about our genes and how we react differently to diseases and to treatment, personalised medicine becomes increasingly important. Genomic medicine is the use of genomic information in clinical decision-making and patient care. This type of personalised medicine can be used to support more accurate diagnosis and prognosis, to identify patients at a greater risk of disease or complications, to select and prioritise therapy and in the prevention and control of outbreaks of infections.

Murdoch Childrens has always been at the forefront of genetics and, using in-house genetic technologies, our researchers have been able to discover many new disease genes. Gene discovery is the first step towards developing effective treatments. However, whilst this technology is being used in a research laboratory setting, these dramatic advances in genomic research are not yet routinely available in the clinical setting. AGRF. Genomics: National Insights of Australians. Database Access - UNSW Library. Pharmacogenetics and Stratified Medicine MSc. The Dr. John T. Macdonald Foundation Department of Human Genetics at Miller School of Medicine.

Overview Congratulations to the 2015 MD/MS Genomic Medicine students Be a part of the future of genomic and personalized medicine! This 4-year concurrent master’s degree in Genomic Medicine will provide you with the background, knowledge, and understanding to integrate the ever expanding field of genomics into your practice. No matter which medical specialty you choose, genomic medicine is increasingly becoming an integral part of patient care with the use of predictive clinical sequencing, pharmacogenetics, and whole genome analysis. Educational Mission of the MD/MS Program in Genomic Medicine The educational mission of the program is to graduate clinicians with the ability to integrate genomic knowledge into their clinical practice. UCSF Steps Forward to Lead Advances in Precision Medicine. UC San Francisco convened 170 of the world’s foremost thinkers, creators and innovators last month at the OME Precision Medicine Summit to identify new approaches and spur action to make medicine more predictive, preventive and precise.

Now, the ideas generated at the summit in May are moving ahead across the University and the nation as part of many focused efforts to make precision medicine a reality. The promise of precision medicine – the next revolution in health – is described by leaders, including Francis Collins, MD, PhD, director of the National Institutes of Health, in a newly released four-minute video highlighting the urgent need to fundamentally transform the practice of medicine to improve health and save lives. Pharmacogenomics and Personalised Health Care (PHAR4201) / Course / The University of Newcastle, Australia. TEDMED - Home. Theconversation.

Drink red wine to prevent cancer. Targeted Agent & Profiling Utilization Registry Study (TAPUR) NCI-Molecular Analysis for Therapy Choice Program (NCI-MATCH) Mayo Clinic to Study 10,000 Patients for Drug-Gene Safety. “Why Do We Have to Learn This Stuff?”—A New Genetics for 21st Century Students. Mayo Clinic to Study 10,000 Patients for Drug-Gene Safety. NYU CENTER FOR HEALTH INFORMATICS AND BIOINFORMATICS. Editorial Virtual Special Issue: Health Behavior Change. DCCPS: Health Behavior Constructs: Theory, Measurement, & Research. Integrated Theory of Health Behavior Change. Collins and Varmus Outline Potential of Precision Medicine Initiative in NEJM Perspective. Clinical Pharmacology & Therapeutics - Volume 95 Supply Chain Management & Personalized Medicine - February 2014. Clinical Pharmacology & Therapeutics - Volume 94 Genomic Medicine - August 2013. Hepatitis C (chronic) - sofosbuvir [ID654] Hepatitis C (chronic) - sofosbuvir [ID654]

NICE consults on further draft guidance on the drug sofosbuvir (Sovaldi) for treating hepatitis C. Hepatitis C is a virus that infects the liver. It is spread by contact with infected blood, for instance by using contaminated needles for injecting drugs or sharing razors or toothbrushes. The virus can cause inflammation of, and damage to the liver, preventing it from working properly. Although 15 to 20% of people infected with the hepatitis C virus naturally clear their infections within 6 months, the remainder develop chronic hepatitis which can be life-long. Figures from 2012 suggest that around 160,000 people are chronically infected with the hepatitis C virus in England. Pharmacogenetics, Pharmacogenomics, and Individualized Medicine. David R. Sibley, ASSOCIATE EDITOR. VEGF and EGFR pathways in detail: Target for new therapies against cancer.

Epidermal growth factor receptor EGFR Tyrosine kinase. Higher Education. Marks-Clerk-Life-Sciences-Report-2014.pdf. Social Media Push to Get Experimental Drugs on the Rise. <br/><a href=" more news videos</a> | <a href=" from the US</a> Copy For a growing number of gravely ill patients running out of options, social media has become their last bastion of hope. And they're sharing their private struggles to motivate public action. A young newlywed woman smiles for a blog photo despite obvious signs of illness: a cannula in her nose, and a bald head. A group of doctors pose in their scrubs holding signs bearing hashtags to support a sick teen.

They are dying. When patients don’t qualify for clinical trials to get experimental drugs, they try to get them via compassionate use programs, meaning they can take the drugs on their own with their doctor’s oversight and approval from the U.S. Bowing to public outrage, pharma company to give dying boy experimental drug. Josh Hardy Going Home After Getting Chimerix Anti-Viral Drug. Genes and inheritance. Learn Genetics. Resources, Animations, Interviews, + Tools. We are enhancing our most popular resources by building collections around them.

First up: Polymerase Chain Reaction! The DNA Learning Center has been developing multimedia animation programs since 1990. These popular programs feature some of the most common molecular processes such as PCR, sequencing, and DNA restriction. View online or download for play from your computer. Refining Processes for the Co-Development of Genome-Based Therapeutics and Companion Diagnostic Tests: Workshop Summary. Genomics > Table of Pharmacogenomic Biomarkers in Drug Labeling. Personalized Medicine. Genetics Home Reference - Your guide to understanding genetic conditions.

Walter and Eliza Hall Institute of Medical Research. Personalized Medicine and You - The Jackson Laboratory. Genomic testing paves way for personalised medicine. Ucm372421.pdf. Personalized Medicine Coalition.