Biomarker & drug development opportunities in telomerase cancer. Over 10 million new cancer cases will be diagnosed worldwide over the next year and there is an unmet need for effective, less toxic cancer therapeutics. Our rapidly expanding understanding of how cellular immortality contributes to cancer progression offers an opportunity for the exploitation of the underlying molecular mechanisms into safe and effective new therapies. Telomerase activation is a hallmark of cancer. Advancement of telomerase as a therapeutic drug target has paved the way for translational opportunities in the related fields of senescence and cancer stem cells. Here, lessons may be learnt that can be applied to drug discovery, particularly with regard to the need to appreciate the relationships between telomerase, senescence, and cancer stem cells.
Nicol Keith. Home. Nicol Keith | Grants and Research | Cancer Research UK. Profile. Profile for Nicol Keith. Nicol Keith D-3325-2009 - ResearcherID.com.