MPD - SNP / genotype variation query. Below are some user hints.
For resource documentation click here. Video tutorial sessions 12, 13 and 10 demonstrate some SNP retrievals. Standard retrievals use Sanger1 (SNPs, 56+ million locations, 19 inbred strains) except for queries on rs numbers and other exact locations in which case the 5 larger inbred strain SNP data sets are searched. MPD - Strain polymorphism: Smad5. Smad5 MGI Mouse Gene Detail - MGI:1328787 - SMAD family member 5. The discovery of how gender influences age immu... [Immun Ageing. 2012. Live Longer: The One Anti-Aging Trick That Works. Anti-Aging Protein Extends Life Span in Mice, and Maybe Humans.
Things are looking up for aging mice and, if this research pays off, for aging humans, too.
Researchers have found that a long-suspected anti-aging protein called sirtuin can make male mice live about 16 percent longer than average, the first such advance for mammals in a field that has thus far only offered the blessings of extended life span to yeast, nematodes and fruit flies. The findings, by scientists at Bar-Ilan University in Israel, appear today (Feb. 22) online in the journal Nature.
Although the Israeli scientists cannot explain why female mice didn't also live longer like the males, an accompanying commentary describes the findings as bringing the field of anti-aging research to a new level of maturity. Bullying, Child Abuse Hasten Aging in Kids. Children exposed to multiple instances of violence age faster on a cellular level than children without violent experiences, a new study finds.
Although childhood stress has long been linked with later disease risk and health problems, the study is the first to show accelerated biological aging in childhood as a result of stress. Bees Do It: Brain Aging Reversed. When older honeybees take on tasks usually handled by younger bees, aging of their brains is effectively reversed, a new study finds.
The discovery suggests that in humans, social intervention ought to be considered in addition to drugs as a way to treat age-related dementia. "We knew from previous research that when bees stay in the nest and take care of larvae — the bee babies — they remain mentally competent for as long as we observe them," explained Gro Amdam, who led the research at Arizona State University. “However, after a period of nursing, bees fly out gathering food and begin aging very quickly. " DNA Protein Has Dual Purpose. This Research in Action article was provided to LiveScience in partnership with the National Science Foundation.
Although our cells have many different purposes, they adhere to the same general agenda — the cell cycle. Over four phases, cells grow, copy their genetic material and divide. Helping the process is a plethora of proteins, each with a specific job in the cell’s intricate reproductive process. If a protein isn’t at the right place at the right time, the resulting new cells can have mutations that get passed on and on. Progressive supranuclear palsy. Progressive supranuclear palsy (PSP) (or the Steele-Richardson-Olszewski syndrome, after the Canadian physicians who described it in 1963) is a degenerative disease involving the gradual deterioration and death of specific volumes of the brain. Males and females are affected approximately equally and there is no racial, geographical or occupational predilection.
Approximately 6 people per 100,000 population have PSP. It has been described as a tauopathy. Symptoms and signs This patient presented with progressive dementia, ataxia and incontinence. Atherosclerosis. Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a specific form of arteriosclerosis in which an artery wall thickens as a result of the accumulation of calcium and fatty materials such as cholesterol and triglyceride.
It reduces the elasticity of the artery walls and therefore allows less blood to travel through. This also increases blood pressure. It is a syndrome affecting arterial blood vessels, a chronic inflammatory response in the walls of arteries, caused largely by the accumulation of macrophages and white blood cells and promoted by low-density lipoproteins (LDL, plasma proteins that carry cholesterol and triglycerides) without adequate removal of fats and cholesterol from the macrophages by functional high-density lipoproteins (HDL) (see apoA-1 Milano).
Alzheimer's disease. Amyotrophic lateral sclerosis. Signs and symptoms The disorder causes muscle weakness and atrophy throughout the body due to the degeneration of the upper and lower motor neurons.
Unable to function, the muscles weaken and exhibit atrophy. Individuals affected by the disorder may ultimately lose the ability to initiate and control all voluntary movement, although bladder and bowel sphincters and the muscles responsible for eye movement are usually, but not always, spared until the final stages of the disease. Cognitive function is generally spared for most patients, although some (about 5%) also have frontotemporal dementia. A higher proportion of patients (30–50%) also have more subtle cognitive changes which may go unnoticed, but are revealed by detailed neuropsychological testing.
Initial symptoms The earliest symptoms of ALS are typically obvious weakness and/or muscle atrophy. About 25% of cases are "bulbar onset" ALS. Progression Late stage Cause(s) Huntington's disease.