River of five colors, as the locals call it, originates in the south of the mountain chain Macarena, Colombia, and flows eastward to its confluence with the Guayabero river. In the Cano Cristales found five colors: yellow, blue, green, black and red. All of them are waste product of many algae and, depending on time of year, color saturation, or weakened or strengthened. Share on Tumblr. Crystal River - The most beautiful river on earth [Pics] - StumbleUpon.