Genetics Alien Project, landscape. Epigenetic changes discovered in major psychosis. Scientists have discovered epigenetic changes (i.e. chemical changes to a gene that do not alter the DNA sequence) in individuals with schizophrenia and bipolar disorder.
This is the first epigenome-wide investigation in psychiatric research, and this groundbreaking data may be a significant step on the journey to fully understanding major psychosis. Dr. Arturas Petronis, senior scientist in the Krembil Family Epigenetic Laboratory at the Centre for Addiction and Mental Health (CAMH), and his team studied 12,000 locations on the genome using an epigenomic profiling technology developed at CAMH. Approximately one in every two hundred of these genes showed an epigenetic difference in the brains of psychiatric patients. Significantly, these changes were noted on genes involved in neurotransmission (the exchange of chemical messages within the brain), brain development, and other processes linked to disease origins. Dr. Source: Centre for Addiction and Mental Health. Butter Flavoring Ingredient in Microwave Popcorn, Thought Safe for Food Industry Workers, Is a Respiratory Hazard.
Printer friendly version Share 13 August 2012 Elsevier New Findings Reported in The American Journal of Pathology.
The Ghost In Your Genes. Salk Scientists discover "hidden" code in DNA evolves more rapidly than genetic code. LA JOLLA, CA—A "hidden" code linked to the DNA of plants allows them to develop and pass down new biological traits far more rapidly than previously thought, according to the findings of a groundbreaking study by researchers at the Salk Institute for Biological Studies.
The study, published today in the journal Science, provides the first evidence that an organism's "epigenetic" code - an extra layer of biochemical instructions in DNA - can evolve more quickly than the genetic code and can strongly influence biological traits. Epigenomics. Epigenetics Explained [Animation] Epigenetics. We investigate the different components of the epigenetic regulation of synovial fibroblasts.
In rheumatoid arthritis, these cells play a major role in the destructive process, showing spontaneous expression of matrix degrading enzymes. They destroy cartilage and bone without support of cells of the immune system. This intrinsic activity appears to be an imprinted behavior; it is hypothesized that the epigenetic regulation of these cells is impaired. Epigenetics is the study of all heritable and potentially reversible changes in genome function that do not alter the nucleotide sequence within the DNA. Nuclear pore complexes harbor new class of gene regulators. Nuclear pore complexes are best known as the communication channels that regulate the passage of all molecules to and from a cell's nucleus.
Researchers at the Salk Institute for Biological Studies, however, have shown that some of the pores' constituent proteins, called nucleoporins, pull double duty as transcription factors regulating the activity of genes active during early development. This is the first time nucleoporins' gene regulatory function has been demonstrated in multicellular organisms, and these findings, reported in the Feb. 5, 2010 issue of Cell, not only reveal a new class of transcription factors but may offer new insights into the mechanisms behind cancer.
"Nuclear pores are not only transport channels but play a role in the organization of the genome and a very direct role in gene expression," says senior author Martin Hetzer, Ph.D., Hearst Endowment associate professor in Salk's Molecular and Cell Biology Laboratory. Huntington’s gene mutation carriers: Learning faster with neurodegenerative disease. Printer friendly version Share 14 September 2012 Ruhr-Universitaet-Bochum Learning faster with neurodegenerative disease RUB researchers examine Huntington’s gene mutation carriers Severity of the genetic mutation related to learning efficiency.
Genetic errors identified in 12 major cancer types. Examining 12 major types of cancer, scientists at Washington University School of Medicine in St.
Louis have identified 127 repeatedly mutated genes that appear to drive the development and progression of a range of tumors in the body. The discovery sets the stage for devising new diagnostic tools and more personalized cancer treatments. The research, published Oct. 17 in Nature, shows that some of the same genes commonly mutated in certain cancers also occur in seemingly unrelated tumors. 'Moonlighting' Molecules Discovered; Researchers Uncover New Kink In Gene Control. Since the completion of the human genome sequence, a question has baffled researchers studying gene control: How is it that humans, being far more complex than the lowly yeast, do not proportionally contain in our genome significantly more gene-control proteins?
Now, a collaborative effort at the Johns Hopkins School of Medicine to examine protein-DNA interactions across the whole genome has uncovered more than 300 proteins that appear to control genes, a newly discovered function for all of these proteins previously known to play other roles in cells. The results, which appear in the October 30 issue of Cell, provide a partial explanation for human complexity over yeast but also throw a curve ball in what we previously understood about protein functions.
The team set out to figure out which proteins encoded by the genome bind to which DNA sequences. Comparison of Meiosis and Mitosis (Quiz 1) GeneEd - Genetics, Education, Discovery. Pedigree Quests - Genetics. Drag-and-Drop Pedigree 1: Tongue Rolling. The Blood Typing Game.
If you’re totally stumped, you can tell the computer to show you the answer to a particular question. Monohybrid Cross: In humans, brown eyes (B) are dominant over blue (b)*. A brown-eyed man marries a blue-eyed woman and they have three children, two of whom are brown-eyed and one of whom is blue-eyed. (* Actually, the situation is complicated by the fact that there is more than one gene involved in eye color, but for this example, we’ll consider only this one gene.) Genetic map. Flashcards for Basic Principles of Genetics: Stack 2. Flashcards for Basic Principles of Genetics: Stack 1. Genetics extra credit. Understanding Genetics: Human Health and the Genome. Virtual blood typing lab.
Acquired traits can be inherited via small RNAs. Columbia University Medical Center (CUMC) researchers have found the first direct evidence that an acquired trait can be inherited without any DNA involvement.
The findings suggest that Lamarck, whose theory of evolution was eclipsed by Darwin's, may not have been entirely wrong. The study is slated to appear in the Dec. 9 issue of Cell. "In our study, roundworms that developed resistance to a virus were able to pass along that immunity to their progeny for many consecutive generations," reported lead author Oded Rechavi, PhD, associate research scientist in biochemistry and molecular biophysics at CUMC. Color Blind Chart.
Pattern baldness in men is a sex-influenced trait. It is not an X-linked trait like color blindness and hemophilia. Baldness is an autosomal trait and is apparently influenced by sex hormones after people reach 30 years of age or older. This condition is inherited as a simple Mendelian trait, although the biochemical mechanism is complex. There are other causes for baldness not related to simple Mendelian genetics, such as illness, severe stress, and pulling one's hair out by the roots.
Quick Trait Calculator - Genetic Heredity Calculator. Note These calculators use simplified models to calculate traits and their certainty is far from 100% due to the fact that human genetics is far more complex than a simple mendelian dominant/recessive model. Personal Report and Heredity Report give better results, providing that you had your genome sequenced by a commercial personal genomics companies like 23andMe, deCODEMe or Family Tree DNA. In any case, these reports do not substitute for clinical tests, genetic counseling or paternity/maternity tests.
If you have questions about your genetic heritage, its relation to diseases or any other health-related issues you should consult your doctor. Alcohol Flush Reaction. 100 Years of Breed “Improvement” For the sake of honest disclosure, I will admit to owning “purebreds” (the ‘pureness’ of purebreeds is a discussion for another time) but I also have mutts. All the dogs I’ve had since childhood had a few things in common, they were friendly, prey driven, ball-crazy, intense, motivated, athletic (crazy dogs are easier to train) and none had intentionally bred defects. I would never buy/adopt a dog whose breed characteristics exacted a health burden. Extraordinary Adaptation. Chpt 3 One Wrong Letter. Extinct frog hops back into the gene pool. In what may be considered an early Easter miracle, an extinct species of native frog has begun its rise from the dead.
Australian scientists have grown embryos containing the revived DNA of the extinct gastric-brooding frog, the crucial first step in their attempt to bring a species back to life. The team from the aptly named Lazarus project inserted the dead genetic material of the extinct amphibian into the donor eggs of another species of living frog, a process similar to the technique used to create the cloned sheep Dolly. What human faces might look like in 100,000 years. Since we humans are prone to launching chemical weapons, unwittingly killing off the bee population or other factors that could lead to our extinction, it may be presumptuous to imagine what we'll look like in 100,000 years.
Detective Punnett Square: connecting families by genetics. Rediscovering Biology - Case Studies: Designing Cancer Drugs. Although they are best known for their use in agriculture to increase yields and fight crop diseases, genetic modification techniques are used in many different areas of biological research, including medicine. Rediscovering Biology - Case Studies: The Genetics of Resistance to HIV Infection. This case uses the example of HIV, to explore the relationships between viruses, cells and the immune system, and the role of genes in disease resistance.
Famous names. Introduction to Genetics. Introduction To Heredity. Gene Therapy in Sports: Gene Doping. The Biology Project: Human Biology. DNA Extraction from Wheat Germ. DNA Extraction from Wheat Germ. A Brief Introduction to Genetics. GeneCards. Genetics Practice Problems. Rediscovering Biology - Case Studies: Designing Cancer Drugs. A Question of Genes: Program Overview. ApGeneticsProblems2foglia. Epigenetics. The Ductile Helix: "Jumping Genes" May Influence Brain Activity. Mobile DNA molecules that jump from one location in the genome to another may contribute to neurological diseases and could have subtle influences on normal brain function and behavior, according to a study published October 30 in Nature.
(Scientific American is part of Nature Publishing Group.) The Illustrated Guide to Epigenetics. Acquired traits can be inherited via small RNAs. Drosophila. Understanding Genetics. People with blue eyes have common ancestor. 18 Things You Should Know About Genetics. YourGenome.org. Genetics Home Reference - Your guide to understanding genetic conditions. Kentucky Blues. SickleCell_Genetics_Student. Danny Hillis: Understanding cancer through proteomics.
Color Blind Chart.