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Week 5 - Biology of Cancer

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The Control of the Cell Cycle. Cell Cycle: An Interactive Animation. During development from stem to fully differentiated, cells in the body alternately divide (mitosis) and "appear" to be resting (interphase). This sequence of activities exhibited by cells is called the cell cycle. Follow the events in the entire cell cycle with the following animation. Interphase: Interphase, which appears to the eye to be a resting stage between cell divisions, is actually a period of diverse activities. Those interphase activities are indispensible in making the next mitosis possible. Interphase generally lasts at least 12 to 24 hours in mammalian tissue.

During this period, the cell is constantly synthesizing RNA, producing protein and growing in size. Gap 0 (G0): There are times when a cell will leave the cycle and quit dividing. Gap 1 (G1): Cells increase in size in Gap 1, produce RNA and synthesize protein. S Phase: To produce two similar daughter cells, the complete DNA instructions in the cell must be duplicated. Stages of Colorectal Cancer with Dukes and TNM staging system | Health Topics. 1. Older colorectal cancer stages is based on Dukes staging system. Stage 1: (Dukes'A): 0) lesions limited to mucosal layer (carcinoma in situ). 1) invasion and submucosal lesions. 2) muscular lesion invading the intestinal wall. Stage 2 (Dukes'B): lesions and serosal invasion, or invasion and the surrounding tissues and organs, but en bloc resection can be together.

Stage 3 (Dukes'C): 1) with lesions near the lymph node metastasis (refer to the side or on the edge of blood vessel wall adjacent to lymph node metastasis). 2) with the supply of blood vessels and mesangial margin near the lymph node metastasis. Stage 4 (Dukes'D): 1) with distant organ metastasis (such as liver, lung, bone, brain metastasis, etc.). 2) with distant lymph node metastasis (such as the supraclavicular lymph node metastasis, etc.), or the supply of blood vessels can not be the root of all lymph node metastasis resection. 2.

T: The degree of invasion of the intestinal wall T0 - no evidence of tumor N0 - no lymph nodes involved. Union for International Cancer Control. Staging and Grading Cancer. If left untreated, cancers often go through three stages: 1. Local growth and damage to nearby tissues Cancer cells multiply quickly. A cancerous (malignant) tumour is a lump or growth of tissue made up from cancer cells. Cancerous tumours normally first develop in one site - the primary tumour. Cancer cells also have the ability to push through or between normal cells. 2. Some cancer cells may get into local lymph channels. 3. Some cancer cells may get into a local small blood vessel (capillary). There are more than 100 different types of cancer. Carcinomas are cancers that arise from cells which line a body surface, or the lining of a gland - for example, the skin, or the lining of the gut, mouth, cervix, airways, etc.Sarcomas are cancers that arise from cells which make up the connective tissues such as bones or muscles.

The five most common cancers in the UK are: breast, lung, prostate, bowel and skin cancer. Staging is a way of describing how much a cancer has grown and spread. Healthtalkonline, an award-winning charity website, lets you share in patients, family and professional experiences of health and illness. : Healthtalkonline. Chronic Myelogenous Leukemia Treatment (PDQ®) Treatment statement for Health professionals Get this document via a secure connection General Information About Chronic Myelogenous LeukemiaStage Information for Chronic Myelogenous LeukemiaTreatment Option OverviewChronic-Phase Chronic Myelogenous LeukemiaAccelerated-Phase Chronic Myelogenous LeukemiaBlastic-Phase Chronic Myelogenous LeukemiaRelapsing Chronic Myelogenous LeukemiaChanges to This Summary (11/18/2013)About This PDQ SummaryGet More Information From NCI General Information About Chronic Myelogenous Leukemia Incidence and Mortality Estimated new cases and deaths from chronic myelogenous leukemia (CML) in the United States in 2013: [1] New cases: 5,920.Deaths: 610.

CML is one of a group of diseases called the myeloproliferative disorders. Polycythemia vera.Myelofibrosis.Essential thrombocythemia. (Refer to the PDQ summary on Chronic Myeloproliferative Disorders Treatment for more information.) References: Stage Information for Chronic Myelogenous Leukemia Chronic-phase CML. Malignant melanoma - Cancer Information. Lecture resources. Colposcopy. Cervical Screening Programme (NHSCSP) If you have been invited for screening, or have been for screening and have any questions about the result, you should contact the name and address shown on your invitation letter or result letter. If you are worried about a specific problem, or otherwise worried about the risks of cancer, then you should talk to your GP.

Screening is for people without symptoms. If you are concerned about any symptoms, please contact your GP or visit NHS Direct Online. Remedica cervical screening DVDs Click on the images below to view the English language patient modules. The modules are also available in Urdu, Gujarati, Punjabi, Bengali and Cantonese languages. All modules, including those for physicians, are available; Remedica cervical screening DVDs.

Copies of the DVD are obtainable from the publications orderline. Information Resources There is a variety of information available in different formats designed to assist in answering questions about cervical screening.