NCI Cancer Bulletin for June 29, 2010. NCI Cancer Bulletin for June 29, 2010. Gefitinib Improves Progression-free Survival for Metastatic Lung Cancers with EGFR Mutations Patients newly diagnosed with metastatic non-small cell lung cancer (NSCLC) who received gefitinib (Iressa) had significantly higher response rates and longer progression-free survival compared with patients who received carboplatin plus paclitaxel (73.7 percent versus 30.7 percent and 10.8 months versus 5.4 months, respectively), according to results of a phase III trial conducted in Japan. The results were published in the June 24 New England Journal of Medicine . All patients enrolled in the study had epidermal growth factor receptor (EGFR) mutations that were sensitive to the tyrosine kinase inhibitor (TKI) gefitinib.
The patients did not have the resistant EGFR mutation T790M, and they had not been previously treated with chemotherapy. The researchers, led by Dr. Study Finds Poor Physician Adherence to Cervical Cancer Screening Guidelines. New developments in pancreatic cancer @AACR - Pharma Strategy Blog. Pancreatic cancer is a devastating disease with a generally poor prognosis, largely because it is usually detected in late stage disease where chemotherapy options generally have a limited effect.
Typically response rates with gemcitabine are around 5%, with advanced patients living around 5-6 months on average. Erlotinib, an EGFR inhibitor, is also approved in the USA for treatment of the disease, but the therapy only adds approximately two weeks to survival. Many doublets and triplets have been tried and tested over the last 10 years, with little impact on survival. It was, therefore, exciting to see some young researchers presenting interesting and novel strategies at AACR this week to try and evade the resistance inherent in the disease.
Celgene buy Abraxis Bioscience for $2.9B - Pharma Strategy Blog. I did a double take at my inbox alerts this morning as things have been rather quiet of late in the Pharma and Biotech world.
You can read the financial aspects of the deal in Celgene's press release. While the timing might be a little bit of a surprise, the strategic acquisition is not and makes a lot of commercial sense for Celgene. Childhood's Cures Haunted by Adulthood's 'Late Effects' NCI Cancer Bulletin for June 29, 2010. Gefitinib Improves Progression-free Survival for Metastatic Lung Cancers with EGFR Mutations Patients newly diagnosed with metastatic non-small cell lung cancer (NSCLC) who received gefitinib (Iressa) had significantly higher response rates and longer progression-free survival compared with patients who received carboplatin plus paclitaxel (73.7 percent versus 30.7 percent and 10.8 months versus 5.4 months, respectively), according to results of a phase III trial conducted in Japan.
The results were published in the June 24 New England Journal of Medicine . All patients enrolled in the study had epidermal growth factor receptor (EGFR) mutations that were sensitive to the tyrosine kinase inhibitor (TKI) gefitinib. The patients did not have the resistant EGFR mutation T790M, and they had not been previously treated with chemotherapy. The researchers, led by Dr. Study Finds Poor Physician Adherence to Cervical Cancer Screening Guidelines. Obesity increases the risk of cancer death among Asians too. Historically, obesity has been a problem of western countries.
For instance, nearly 1 in 3 Americans is obese (defined as having a body mass index that tops 30), as are about 1 in 4 members of the United Kingdom. According to this ranking compiled with data from the Organization for Economic Cooperation and Development, the most obese countries in Asia are Japan and South Korea, where a mere 3.2% of the population has a BMI over 30. But with obesity rates rising in China, South Korea, Thailand, Singapore and other Asian countries, an international group of researchers wondered how those extra pounds might be raising the risk of death from cancer.
After all, adding 5 points to one’s BMI is known to increase the risk of cancer among Caucasians by 10% to 60%. MELA's Stock Sale Suggests Problems for Skin Cancer Detector. Update: MELA Sciences priced 2.2 million shares of stock at $7.50 a share Wednesday.
MELA expects to gross about $17.5 million, including the sale of over-allotment shares. MELA tried to get $8 a share for the stock offering Tuesday night, according to a source familiar with the deal terms. IRVINGTON, NY (TheStreet) -- MELA Sciences (MELA_) CEO Joseph Gulfo explained to investors on a Tuesday night conference call that the company decided to raise money now -- just two months shy of an all-important FDA advisory panel reviewing the company's melanoma skin cancer detection device -- because investors are worried that MELA is running short on cash. Hmm... Celgene strikes $2.9B deal to acquire Abraxis. With an eye to burnishing its oncology rep and its already sizable revenue, Celgene has struck a deal to buy Abraxis BioScience for cash and stock totaling $2.9 billion.
Ethnic Supplies Ltd's Photos - Ethnic Supplies At BBC GWL. The Gov't Controls Google's Search Results for Your Brand. Surprised? Did you notice that lately, every time you search for a pharma brand on Google, the #1 organic result is always the NIH?
Always? Always. It's not the brand.com site anymore. And it's no coincidence. Celgene Acquires Abraxis for $2.9 Billion. SUMMIT, N.J.
(TheStreet) -- Celgene (CELG_) is acquiring Abraxis BioScience (ABII) for $2.9 billion in cash and stock to expand its cancer drug business, the company announced Wednesday. Celgene is one of the largest biotech companies in the world, with revenue of $2.7 billion last year coming mainly from drugs like Revlimid used to treat cancers of the blood. By acquiring Abraxis, Celgene gains ownership of a drug used to treat breast cancer patients and expands the company's commercial operations into the solid tumor market.
I'm Had Enough: Half of BC Survivors Stop Tamoxifen Early. This is a headline that quadruples my empathy factor: "Half of breast cancer patients stop taking hormone drugs.
" I've been there. I did that. And damn, I'm here to tell you about it. But first, here's what was reported, from USA Today by Liz Szabo Half of breast cancer patients stop taking hormone drugs and from the American Society of Clinical Oncology Fewer than half of breast cancer survivors adhere.... from a study of 8800 women with early-stage breast cancer. Researchers found that only 49 percent of the women completed the recommended regimen for tamoxifen, aromatase inhibitors or both. 30 habits that will improve your life. Our worst habits are always the hardest ones to break, but if you can manage to insert at least a few of these positive habits into your daily routine, you’ll be ahead of the game.
See a few below: Drink a glass of water when you wake up. Quick Financial Fixes - Forbes.com. How cognitive surplus will change the world: Clay Shirky - Pharma Strategy Blog. Here's an interesting and informative TED video I just came across, where Clay Shirky talks about cognitive surplus and how it will change the world.
The idea behind the concept of "cognitive surplus" is that we use spare brain cycles while online to build a more cooperative world. In other words, new technologies enable loose collaborations to evolve. I'm not sure I like the term 'cognitive surplus' but Shirky is an eloquent, thoughtful and engaging speaker who is well worth listening to: A Different Look at Community Management « Social Media Monitoring and Engagement – Radian6. Community management isn’t what it used to be. Once upon a time, managing a community meant hanging out in an online location – be it a forum or a chat room – and moderating chat. Approving comments. Handling some support issues.
Dealing with trolls, helping people with questions. That kind of thing. Finding pharma on your mobile device (early opportunities for exploration) Before looking at pharma companies testing out the mobile space, I want to introduce you to another healthcare organization that is diligently studying this channel. A hospital system, you say? Nope. Insurance plan? Sorry. It's actually none other than the US government. At the Business Development Institute (BDI) Social Communications and Healthcare Conference last month, Centers for Disease Control and Prevention (CDC) Social Media Strategist Ann Aikin presented "Going Social 4 Health Impact," which you can view thanks to VEOMED.
Last fall, the CDC invited Americans to opt in for text messages about a variety of health topics. Chain of transplants gives 14 kidney patients new life. Phil's Vacation: Day +5. Phil's Bone Marrow. 800,000 Strong Boycott BP Facebook Fan Page Mysteriously Vanishes. Porter Novelli unveils global service for brands experiencing social media crises. Many Americans overtreated to death - Health - Cancer. UK scrambles to keep 'dozen eggs' in EU battle. Steve Woodruff - Yeah, this works...! - TwitVid. Gefitinib or Chemotherapy for Non–Small Cell Lung Cancer with Mutated EGFR - Pharma Strategy Blog.
Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2 [Cell_Biology] Early dinner, something tasty to go with it and then several. Eidogen-Sertanty. Warfarin For Early Cancer Detection? June 27th, 2010 by John Mandrola, M.D. in Better Health Network, Opinion, Research, True Stories In cancer treatment, detection of a tumor in an early stage markedly increases the chance of favorable outcomes. Can the much-aligned blood thinner, warfarin, occasionally help in early detection of cancer? Few pharmacologic agents receive more bad press than warfarin. Stories, which are too numerous to count, like “Did warfarin kill my father,” can be widely found on Internet forums, search engines, and are often quoted by reluctant patients — whose numerator of bad warfarin experiences is one. It is true that warfarin has a narrow therapeutic window — a small difference between an effective dose and dangerous dose.
Anecdote… 2010 FIFA World Cup: No doping positives for 4th straight World Cup. Chicago Journals - The Journal of Infectious Diseases. Podcamp Boston 5! - PCB5- Eventbrite. Apple Nation. Share photos on Twitter. Eye on FDA: Clinical Trials and YouTube. Eye on FDA: Growing Use of Video Related to Clinical Trials. Inexpensive camera diagnoses cancer. Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits. @blehr11 neither but this was yummy. A Grand Hyatt Stay « StickyFigure.