Mosaicismo. Estrogen Receptors/SERMs. Skip to content In English | En español Understanding Cancer Series < Back to Main Posted: 10/15/2010.
The ErbB Family - Talk and Crosstalk. The ErbB or Epidermal Growth Factor (EGF) family of receptor tyrosine kinases (RTKs) consists of four members: EGF R/ErbB1/HER1, ErbB2/Neu/HER2, ErbB3/HER3, and ErbB4/HER4.
Under normal physiological conditions, the ErbB receptors play crucial roles in propagating signals regulating cell proliferation, differentiation, motility, and apoptosis. The ErbB proteins are not only important for the essential roles they play in normal developmental processes, but also for their association with human tumorigenesis.1 The ErbB family members are receptors for Neuregulins (NRGs) and EGF family growth factors. Retinoblastoma - PubMed Health.