Citalopram Pathway, Pharmacokinetics. Depression, anxiety disorders, and dementia-related behavioral disturbances have been linked to the dysfunction of serotonergic neurotransmission [Article:11336616].
Citalopram is a selective serotonin reuptake inhibitor (SSRI). The molecular target for SSRIs is SLC6A4, resulting in an inhibition of serotonin reuptake from the synaptic cleft as seen in the SSRI pathway. Following oral administration, citalopram is rapidly absorbed, with peak plasma levels observed approximately after 1- 4 hours and a plasma half-life of approximately 35 hours after administration [Articles:729609, 6939299, 17722014].
US7002025.pdf. Patent WO1998019512A2 - Method for the preparation of citalopram - Google Patenter. Method for the Preparation of Citalopram The present invention relates to a method for the preparation of the well known antidepres- sant drug citalopram and intermediates used in the process.
Background of the Invention. Citalopram is a well known antidepressant drug that has now been on the market for some years and has the following structure: Formula I. Patent EP2141156A1 - Process for Preparation of Citalopram and Enantiomers - Google Patents. US4136193.pdf. AO Brochure Grignard. Danskkemi 79 2 1998. Design and Synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (Citalopram) Analogues as Novel Probes for the Serotonin Transporter S1 and S2 Binding Sites. Nihms226631. Emss 57802. Citalopram Capsules - drugs.com.
Rx only Suicidality and Antidepressant Drugs Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders.
Citalopram. Molecular FormulaC20H21FN2O Average mass324.392 Da Monoisotopic mass324.163788 Da ChemSpider ID2669 Systematic name 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile SMILES CN(C)CCCC1(c2ccc(cc2CO1)C#N)c3ccc(cc3)F Copied Std.
InChi InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3 Copied Std. InChIKey WSEQXVZVJXJVFP-UHFFFAOYSA-N Copied Cite this record CSID:2669, (accessed 11:23, Oct 12, 2016) Copied Featured data source. Nyt studie: 'Lykkepiller' har ingen effekt på depression.