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Home | ACToR | US EPA. The PubChem Project. Chemicalize.org. iREP, Répertoire du Registre français des émissions polluantes sur Internet. Recherche des IC. Recherche avancée Généralités Thématiques Secteurs Réglementation Formulaires Base des installations classées Vous êtes ici : Accueil > Recherche des Installations Classées Tous nos sites Base des installations classées Cette base contient les installations soumises à autorisation ou à enregistrement (en construction, en fonctionnement ou en cessation d'activité). Région : Département : Commune : Nom de l'établissement(1): Activité principale : Régime en vigueur de l'établissement(2) : Priorité nationale : Statut Seveso : Déclaration annuelle émissions : (1) En application des dispositions du RGPD, les noms de personnes physiques ne sont pas diffusés (2) Régime en vigueur de l'établissement : Le régime en vigueur d'un établissement correspond au régime de l’établissement avec prises en compte, depuis le dernier arrêté préfectoral de l'établissement, des évolutions de la nomenclature des installations classées qui s'appliquent de plein droit.

Portail d'informations sur l'assainissement communal - Accueil. HYDRO - Accueil. Series on Testing and Assessment: Testing for Endocrine Disrupters. Endocrine Disruptor Screening Program. In the 1990's, some scientists proposed that certain chemicals might be disrupting the endocrine systems of humans and wildlife. A variety of chemicals have been found to disrupt the endocrine systems of animals in laboratory studies, and compelling evidence shows that endocrine systems of certain fish and wildlife have been affected by chemical contaminants, resulting in developmental and reproductive problems.

Based on this and other evidence, Congress passed the Food Quality Protection Act and the Safe Drinking Water Act (SDWA) Amendments in 1996 requiring that EPA screen pesticide chemicals for their potential to produce effects similar to those produced by the female hormones (estrogen) in humans and giving EPA the authority to screen certain other chemicals and to include other endocrine effects. Based on recommendations from an Advisory Committee, EPA has expanded the EDSP to include male hormones (androgens) and the thyroid system, and to include effects on fish and wildlife.

Edsp_chemical_universe_list_11_12. Endocrine Disruptor Screening Program. In the 1990's, some scientists proposed that certain chemicals might be disrupting the endocrine systems of humans and wildlife. A variety of chemicals have been found to disrupt the endocrine systems of animals in laboratory studies, and compelling evidence shows that endocrine systems of certain fish and wildlife have been affected by chemical contaminants, resulting in developmental and reproductive problems.

Based on this and other evidence, Congress passed the Food Quality Protection Act and the Safe Drinking Water Act (SDWA) Amendments in 1996 requiring that EPA screen pesticide chemicals for their potential to produce effects similar to those produced by the female hormones (estrogen) in humans and giving EPA the authority to screen certain other chemicals and to include other endocrine effects. Based on recommendations from an Advisory Committee, EPA has expanded the EDSP to include male hormones (androgens) and the thyroid system, and to include effects on fish and wildlife.

Search — The Endocrine Disruption Exchange. Bkh_main.pdf. Chemicals - Environment. Additional tools What is the basis for concern? Reports of adverse changes in the physiology and behaviour of wildlife apparently linked to exposure to chemical pollutants released into the environment, and the suggestion that humans may also be at similar risk of adverse health effects, have fuelled growing concern about the extent of the risk posed by chemical EDs and calls for action to reduce such risks.

However, modern civilised life involves the use of thousands of chemicals in various processes and products, many of which could eventually find their way into the environment through various routes (e.g. from disposal methods such as landfills, by entering the food chain, from consuming products such as sprays), and at present it is generally unclear which chemicals or processes pose an appreciable risk.

How are the concerns being addressed? Priority list The different steps of the process include: The results of these studies are compiled in a database. 1. ChemSec | Welcome to the SIN LIST. The SIN (Substitute It Now!) List is a concrete tool to speed up the transition to a world free from hazardous chemicals. The chemicals on the SIN List have been identified by ChemSec as Substances of Very High Concern based on the criteria established by the EU chemicals regulation REACH.

The aim of the SIN List is to spark innovation towards products without hazardous chemicals by speeding up legislative processes and giving guidance to companies and other stakeholders on which chemicals to start substituting. There is an urgent need to reduce the use of harmful chemicals in society. Let SIN inspire you and be a concrete tool in your work towards a world with less hazardous chemicals. The SIN List is publically available in our free-of-charge online database.

Search SIN listed chemicals. News. The OECD QSAR Toolbox. Download the ToolboxGuidance Documents and Training MaterialsPublic Discussion ForumFAQs on the Toolbox To increase the regulatory acceptance of (Q)SAR methods, the OECD has started the development of a QSAR Toolbox to make (Q)SAR technology readily accessible, transparent, and less demanding in terms of infrastructure costs.

The Toolbox is developed in phases. The first version emphasises technological proof-of-concept and was released in 2008. The second phase of the project to develop a more comprehensive Toolbox which fully implements the capabilities of the first version was launched in November 2008 and version 2.0 was released in October 2010. What does the Toolbox do? New features of the QSAR Toolbox version are: In version 3.1 of the QSAR Toolbox a number of these new features has been updated or extended and a new database for observed rat in vivo metabolism has been added. In version 3.3 of the QSAR Toolbox several databases have been updated or added. [TOP of page] CEMC - BASL4 Model. The Canadian BASL4 Model Version 1.10 - April 2008 New in version 1.10 Software Description The BASL4, Biosolids-Amended Soil: Level IV, model calculates the fate of chemicals introduced to soil in association with contaminated biosolids amendment. An evaluative calculations of concentrations in vegetation, invertebrates, and small soil-dwelling mammals are performed.

This model is useful for assessing the long-term, year-to-year fate and possible build-up of chemicals in sludge-amended soils as well as for estimating risk of biotic uptake and bioaccumulation in soil-dwelling organisms. The results of changes in chemical and soil properties may be explored by modifying the input data. Features of the BASL4 model: Provides a database of chemicals and chemical properties. This program was based on the following publications: Hughes, L., Mackay, D., Webster, E., Armitage, J., Gobas, F. 2005. Hughes, L., Webster, E., Mackay, D. Hughes, L., Webster, E., Mackay, D. Mackay, D. 2001. Soil Properties: CAESAR. EPA/OPPT/Exposure Assessment Tools and Models/Estimation Program Interface (EPI) Suite Version 3.12 (August 17, 2004)

What Does EPI Suite ™ Do? • The EPI (Estimation Programs Interface) Suite™ is a Windows®-based suite of physical/chemical property and environmental fate estimation programs developed by the EPA’s Office of Pollution Prevention Toxics and Syracuse Research Corporation (SRC). EPI Suite™ uses a single input to run the following estimation programs: KOWWIN™, AOPWIN™, HENRYWIN™, MPBPWIN™, BIOWIN™, BioHCwin, KOCWIN™, WSKOWWIN™, WATERNT™, BCFBAF™, HYDROWIN™, KOAWIN and AEROWIN™, and the fate models WVOLWIN™, STPWIN™ and LEV3EPI™. ECOSAR™, which estimates ecotoxicity, is also included in EPI Suite™. • EPI Suite™ is a screening-level tool and should not be used if acceptable measured values are available.

•A clear understanding of the estimation methods and their appropriate application is very important. Click on the Help tab in EPI Suite™ for detailed information on the methods and models in it. How Do the Individual Models that Make up EPI Suite™ Work? What Do I Need to Use EPI Suite™? Dr. CRAFT - Chemical Reactivity and Fate Tool | Inspiring Chemical Discovery. CRAFT is a software suite that has been designed to assist scientists in the area of product safety, hazard and risk assessment and toxicology to interactively evaluate the chemical reactivity, persistence, biodegradation and fate of chemical compounds in the environment. CRAFT provides decision support to faster estimate the environmental impact of existing chemicals or to discover and optimize better and safer new chemical entities and products.

Features & Functionality User Interface In order to maintain, extend and apply the knowledge base for the evaluation of chemicals, CRAFT consists of two main applications. CRAFT Editor - GUI-based program to inspect, modify and extend the contents of the knowledge baseCRAFT Explorer - GUI-based program providing a wizard-driven interface with a predefined workflow that supports the user during the evaluation session (including command line interface for batch mode execution) Screenshot CRAFT Editor CRAFT Explorer System Requirements Additional Info. CEMC - Fish Model. The Canadian Fish Model Version 2.00 - November 2004 New in version 2.00! Software Description The Fish model is a single organism bioaccumulation model treats the steady-state uptake and loss of an organic contaminant by a fish. The bioconcentration factor (BCF), bioaccumulation factor (BAF), and biomagnification factor (BMF) are calculated.

The uptake processes include respiration through the gills and food consumption. This model is useful for estimating the likely extent of bioaccumulation in the fish and biomagnification from the food to the fish, and the relative importance of each uptake and loss process. Features of the Fish model: Provides a database of chemicals and chemical properties. This program was based on the following publications: Clark, K.E., Gobas, F.A.P.C., Mackay, D. 1990.

Mackay, D. 2001. Webster, E., Cowan-Ellsberry, C.E., McCarty, L. 2004. Required Input Data: Chemical Properties: Properties of the Fish and its Environment: Concentrations: Model Output: Download. VEGA | Virtual models for property Evaluation of chemicals within a Global Architecture. Qsar. Introduction Quantitative Structure Activity Relationships (QSARs) are mathematical models that are used to predict measures of toxicity from physical characteristics of the structure of chemicals (known as molecular descriptors). Acute toxicities (such as the concentration that causes half of a fish population to die) are one example of the toxicity measures that may be predicted from QSARs. Simple QSAR models calculate the toxicity of chemicals using a simple linear function of molecular descriptors: Toxicity = ax1+bx2+c where x1 and x2 are the independent descriptor variables and a, b, and c are fitted parameters. Dragon (version 6.0) was used as the benchmark software for the descriptors in T.E.S.T.

Uses of QSAR Toxicity Models QSAR toxicity predictions may be used to screen untested compounds in order to establish priorities for traditional bioassays, which are expensive and time consuming. Objectives QSAR Methodologies Several QSAR methodologies have been developed: Software disclaimer. PBT Profiler.