Folding please read. The project has pioneered the use of GPUs, PlayStation 3s, and Message Passing Interface (used for computing on multi-core processors) for distributed computing and scientific research. The project uses statistical simulation methodology that is a paradigm shift from traditional computational approaches.[5] As part of the client-server network architecture, the volunteered machines each receive pieces of a simulation (work units), complete them, and return them to the project's database servers where the units are compiled into an overall simulation. Volunteers can track their contributions on the Folding@home website, which makes volunteers' participation competitive and encourages long-term involvement. Folding@home is one of the world's fastest computing systems, with a speed of approximately 40.2 petaFLOPS: greater than all projects running on the BOINC distributed computing platform and making it the world's most powerful computing system.
Project significance[edit] Folding@Home Team - Overclock.net - Overclocking.net. Science Magazine Daily News. Kinetics of Peptide Folding: Computer Simulations of SYPFDV and P. Authors: Mohanty, D.1; Elber, R.1; Thirumalai, D.2; Beglov, D.3; Roux, B.3 Source: Journal of Molecular Biology, Volume 272, Number 3, September 1997 , pp. 423-442(20) Publisher: Academic Press Buy & download fulltext article: The full text article is not available for purchase. The publisher only permits individual articles to be downloaded by subscribers. Abstract: The folding of Ser-Tyr-Pro-Phe-Asp-Val (SYPFDV), and sequence variants of this peptide (SYPYD and SYPFD) are studied computationally in an explicit water environment. Our simulations suggest a kinetic mechanism that consists of three separate stages. We also show the existence of an off the pathway intermediate, suggesting that even in the folding of a small peptide "misfolded" structures can form. Our findings suggest that the process of peptide folding shares many of the features expected for the significantly larger protein molecules.
Document Type: Research Article Publication date: September 1, 1997. Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. Nucleic Acids Res. Jan 10, 1981; 9(1): 133–148. Abstract This paper presents a new computer method for folding an RNA molecule that finds a conformation of minimum free energy using published values of stacking and destabilizing energies.
It is based on a dynamic programming algorithm from applied mathematics, and is much more efficient, faster, and can fold larger molecules than procedures which have appeared up to now in the biological literature. Its power is demonstrated in the folding of a 459 nucleotide immunoglobulin gamma 1 heavy chain messenger RNA fragment. Full text Full text is available as a scanned copy of the original print version. Articles from Nucleic Acids Research are provided here courtesy of Oxford University Press.
Computer gamers crack protein-folding puzzle - tech - 10 August 2010. How To Build The Best Folding Rig. Folding supercomputers We wanted to determine just how many ppd we could squeeze out of a single PC. Read on to find out the results of our two attempts at building the ultimate folding supercomputer. PC 1: The multiple graphics card challenge Although most motherboards have support for up to two graphics cards, and some support three or four graphics cards, it’s pretty hard to find a motherboard with more than four high-speed PCI-E slots. Enter stage left the Asus P6T7 WS SuperComputer. Despite being a standard-sized ATX motherboard (305 x 244mm), the P6T7 WS SuperComputer has seven 16x PCI-E slots, thanks to its combination of an Intel X58 chipset and nForce 200 PCI-E bridge chip.
Due to the limitations of the ATX spec, if you’re installing seven graphics cards in the P6T7 WS SuperComputer, you have to use cards with single-slot coolers. With all seven GPU clients folding optimally, the ppd of the entire system rose to a terrific 22,742, although its power consumption rose to 524W. How to Build a Folding Computer. Folding@home - Download the Folding@home software application. PC Hardware Reviews and Guides - Get The 'Stats and Stay Informed! By now I'm sure you've heard me pimp the PCStats Folding @ Home Team on the front page and in the newsletter! I've asked you to join, but what exactly is Folding @ Home, and what does it do?
According to Stanford University, where the Folding @ Home distributed computing project originated, the purpose of this project is... "Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. We use novel computational methods and large scale distributed computing, to simulate time scales thousands to millions of times longer than previously achieved. In laymen's terms, that means the Folding @ Home program uses distributed computing to simulate scenarios related to protein folding.
To encourage computational protein folding and participation, the Pande Group brings distributed computing to the next level by allowing for team competition. Once you've entered 13496, press the OK button. Custom PC and bit-tech Folding Team.