Carnegie Institution and UMASS Medical School granted broad US Patent related to RNA interference. The Carnegie Institution for Science and the University of Massachusetts Medical School (UMMS) have been granted United States Patent 8,283,329, entitled, "Genetic inhibition of double-stranded RNA. " The patent, issued on October 9, 2012, is broadly directed to the use of RNA interference (RNAi) to inhibit expression of a target gene in animal cells, including mammalian cells. The process by which RNA, the cellular material responsible for the transmission of genetic information, can silence a targeted gene within a living cell was discovered in 1998 by Carnegie's Andrew Fire, (now a professor at Stanford University) and Craig C. Mello, Howard Hughes Medical Institute Investigator, Blais University Chair in Molecular Medicine and distinguished professor of molecular medicine and cell & developmental biology at UMass Medical School.
The duo received the 2006 Nobel Prize in Physiology and/or Medicine for this work. This document is subject to copyright. New screening method may lead to more efficient RNA drug development. Published on October 10, 2012 at 4:28 AM Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new method of screening more than three million combinations of interactions between RNA and small molecules to identify the best targets on RNA as well as the most promising potential drug compounds. This novel technology may lead to more efficient drug development. The study was published in the October 9, 2012 issue of the journal Nature Communications.
RNA has multiple biological functions, including encoding and translating proteins from genes and regulating the amount of protein expressed under various cellular conditions. Recent studies have identified RNA as a "molecular switch" that controls cellular events such as gene expression, making RNA an attractive target for small molecules that serve as chemical genetics probes, analytical tools or potential drugs. Source: Scripps Research Institute. Screening method aids RNA drug development research. Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new method of screening more than three million combinations of interactions between RNA and small molecules to identify the best targets on RNA as well as the most promising potential drug compounds.
This novel technology may lead to more efficient drug development. The study was published in the October 9, 2012 issue of the journal Nature Communications. RNA has multiple biological functions, including encoding and translating proteins from genes and regulating the amount of protein expressed under various cellular conditions. Recent studies have identified RNA as a "molecular switch" that controls cellular events such as gene expression, making RNA an attractive target for small molecules that serve as chemical genetics probes, analytical tools or potential drugs. Scientists devise screening method to aid RNA drug development research. (Phys.org)—Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new method of screening more than three million combinations of interactions between RNA and small molecules to identify the best targets on RNA as well as the most promising potential drug compounds.
This novel technology may lead to more efficient drug development. The study was published in the October 9, 2012 issue of the journal Nature Communications. RNA has multiple biological functions, including encoding and translating proteins from genes and regulating the amount of protein expressed under various cellular conditions. Recent studies have identified RNA as a "molecular switch" that controls cellular events such as gene expression, making RNA an attractive target for small molecules that serve as chemical genetics probes, analytical tools or potential drugs.
This document is subject to copyright. NextBio : RT @CancerProstate1: RNAi... Researchers discover smallest and fastest-known RNA switches. A University of Michigan biophysical chemist and his colleagues have discovered the smallest and fastest-known molecular switches made of RNA, the chemical cousin of DNA. The researchers say these rare, fleeting structures are prime targets for the development of new antiviral and antibiotic drugs. Once believed to merely store and relay genetic information, RNA is now known to be a cellular Swiss Army knife of sorts, performing a wide variety of tasks and morphing into myriad shapes.
Over the past decade, researchers have determined that most of the DNA in our cells is used to make RNA molecules, that RNA plays a central role in regulating gene expression, and that these macromolecules act as switches that detect cellular signals and then change shape to send an appropriate response to other biomolecules in the cell. Al-Hashimi calls these short-lived structures, which were detected using a new imaging technique developed in his laboratory, micro-switches. Smallest and fastest-known RNA switches provide new drug targets. A University of Michigan biophysical chemist and his colleagues have discovered the smallest and fastest-known molecular switches made of RNA, the chemical cousin of DNA. The researchers say these rare, fleeting structures are prime targets for the development of new antiviral and antibiotic drugs.
Once believed to merely store and relay genetic information, RNA is now known to be a cellular Swiss Army knife of sorts, performing a wide variety of tasks and morphing into myriad shapes. Over the past decade, researchers have determined that most of the DNA in our cells is used to make RNA molecules, that RNA plays a central role in regulating gene expression, and that these macromolecules act as switches that detect cellular signals and then change shape to send an appropriate response to other biomolecules in the cell.
Al-Hashimi calls these short-lived structures, which were detected using a new imaging technique developed in his laboratory, micro-switches. Smallest, fastest-known RNA switches provide new drug targets. (Phys.org)—A University of Michigan biophysical chemist and his colleagues have discovered the smallest and fastest-known molecular switches made of RNA, the chemical cousin of DNA. The researchers say these rare, fleeting structures are prime targets for the development of new antiviral and antibiotic drugs. Once believed to merely store and relay genetic information, RNA is now known to be a cellular Swiss Army knife of sorts, performing a wide variety of tasks and morphing into myriad shapes. Over the past decade, researchers have determined that most of the DNA in our cells is used to make RNA molecules, that RNA plays a central role in regulating gene expression, and that these macromolecules act as switches that detect cellular signals and then change shape to send an appropriate response to other biomolecules in the cell.
Al-Hashimi calls these short-lived structures, which were detected using a new imaging technique developed in his laboratory, micro-switches. FurnoX: The Seed Region of a Small... FurnoX: Escherichia coli noncoding... This Week in Genome Research. Opening up the RNA-chromatin network. In eukaryotic nuclei, DNA is coiled around histone proteins to form nucleosomes. The pattern by which nucleosomes are compacted into higher-order structures determines the accessibility of chromatin and hence it’s transcriptional activity.
Many different factors, including the linker histone H1, histone modifications, chromatin remodelling enzymes and non-histone proteins play important roles in structuring chromatin. Various classes of RNA have also been implicated in regulating the higher-order structure of chromatin. Among many examples; Argonaute associated small silencing RNAs are known to sometimes exert their inhibitory effects by directing histone modifications or DNA methylation and lncRNAs have been shown to serve as cis-acting scaffolds coordinating the action of histone-modifying enzymes. It’s been known for decades that RNA makes up a proportion of chromatin, but exactly what types of RNAs and what their roles are is not yet clear.
Like this: Like Loading... Sciencemagazine: Two subsets of multiple sclerosis... BMC_series : RT @EvaAlloza: Intronic RNAs... Scientists Uncover Common RNA Pathway in ALS and Dementia. Common RNA pathway links frontotemporal lobar dementia with ALS. Two proteins previously found to contribute to ALS, also known as Lou Gehrig's disease, have divergent roles. But a new study, led by researchers at the Department of Cellular and Molecular Medicine at the University of California, San Diego School of Medicine, shows that a common pathway links them. The discovery reveals a small set of target genes that could be used to measure the health of motor neurons, and provides a useful tool for development of new pharmaceuticals to treat the devastating disorder, which currently has no treatment or cure. Funded in part by the National Institutes of Health and the California Institute for Regenerative Medicine (CIRM), the study will be published in the advance online edition of Nature Neuroscience on September 30.
ALS is an adult-onset neurodegenerative disorder characterized by premature degeneration of motor neurons, resulting in a progressive, fatal paralysis in patients. Sciencemagazine: #Gene loops keep #RNA polymerase... Gene Loops Enhance Transcriptional Directionality. Two tiny RNA molecules play a key role in pathological heart growth and failure.
Cardiac stress, for example a heart attack or high blood pressure, frequently leads to pathological heart growth and subsequently to heart failure. Two tiny RNA molecules play a key role in this detrimental development in mice, as researchers at the Hannover Medical School and the Göttingen Max Planck Institute for Biophysical Chemistry have now discovered. When they inhibited one of those two specific molecules, they were able to protect the rodent against pathological heart growth and failure. With these findings, the scientists hope to be able to develop therapeutic approaches that can protect humans against heart failure. Respiratory distress, fatigue, and attenuated performance are symptoms that can accompany heart failure. Germany-wide approximately 1.8 million people suffer from this disease.
A reason for this can be an enlarged heart, a so-called cardiac hypertrophy. Two small RNA molecules tip the balance A microRNA inhibitor protects mice against hypertrophy. In Obesity, a Micro-RNA Causes Metabolic Problems. BMC_series: RT @leclercfl:... Illumina launches new RNA sequencing kits. Illumina (NASDAQ:ILMN) today introduced TruSeq Stranded mRNA and Total RNA Sample Preparation Kits for RNA sequencing. The new reagent kits enable researchers to quickly and easily conduct gene expression studies that provide a complete view of the transcriptome, even from low-quality RNA samples, such as formalin-fixed, paraffin-embedded (FFPE) samples. The Total RNA Sample Preparation Kit efficiently removes ribosomal RNA and other high abundance transcripts using Epicentre's proven Ribo-Zero™ ribosomal RNA reduction chemistry, with an improved workflow optimized for high-throughput studies.
The resulting combination of high-quality ribosomal removal and sample preparation chemistries into a single, streamlined solution provides an exciting new opportunity for researchers to conduct highly-accurate gene expression studies. Scientists Create Tiny RNA Molecule With Big Implications for Life's Origins. LiveLeak.com - Redefining the Media. This Week in PLOS. Plantbiology : Trends in Plant Science 'Plastid... SciReports : Feeder-Free Derivation of Human... From vitro to vivo: Fully automated design of synthetic RNA circuits in living cells. (Phys.org)—Synthetic biology combines science and engineering in the pursuit of two general goals: to design and construct new biological parts, devices, and systems not found in nature; and redesign existing, natural biological systems for useful purposes. For synthetic biologists a key goal is to use RNA to automatically engineer synthetic sequences that encode functional RNA sequences in living cells.
While earlier RNA design attempts have mostly been developed in vitro or needed fragments of natural sequences to be viable, scientists at Institut de biologie systémique et synthétique in France have recently developed a fully automated design methodology and experimental validation of synthetic RNA interaction circuits working in a cellular environment. Their results demonstrate that engineering interacting RNAs with allosteric behavior in living cells can be accomplished using a first-principles computation. Drs. Alfonso Jaramillo, Guillermo Rodrigo, and Thomas E. The many roles of RNAs in Life: „The RNA world” / Svet RNA in molekulska evolucija. The central dogma of molecular biology suggests that biological information is stored in DNA then flows via RNA into proteins, which execute the functions dictated by DNA.
DNA is thought to be the “molecule of life”. With the discovery that ribonucleic acid (RNA) can store genetic information and execute catalytic and regulatory functions, the central dogma is now being challenged. RNA might be at the centre of life, at its origin, driving evolution and regulating cellular activities until today. The RNA world theory proposes that an RNA-based life predated today’s DNA and proteins dominated cellular metabolism.
I will present the current knowledge on the many functions RNA molecules have in controlling cellular metabolism. RNA has an unprecedented structural flexibility and diversity. It is a dynamic molecule, which adopts a large variety of structures. Would you like to put a link to this lecture on your homepage? RNA researcher to receive 2012 Pearl Meister Greengard Prize from The Rockefeller University. Joan A. Steitz, Ph.D., a pioneer in the field of RNA biology whose discoveries involved patients with a variety of autoimmune diseases, will be awarded the 2012 Pearl Meister Greengard Prize from The Rockefeller University. The prize, which honors female scientists who have made extraordinary contributions to biomedical science and carries an honorarium of $100,000, will be presented at a ceremony on Thursday, November 29 at Rockefeller University's Caspary Auditorium.
The Pearl Meister Greengard Prize was established by Paul Greengard, Ph.D., Vincent Astor Professor at Rockefeller University and head of the Laboratory of Molecular and Cellular Neuroscience, and his wife, sculptor Ursula von Rydingsvard. Dr. Greengard donated the proceeds of his 2000 Nobel Prize in Physiology or Medicine to Rockefeller University and, in partnership with generous supporters of the university, created the annual award named in memory of Greengard's mother, who died giving birth to him. Dr. Dr. Dr. Slideserve. Comments Favorited Successfully! Favorite Failed! Already Added! Login To Add! Cannot favorite your own presentation! Please Login to flag this presentation! Your inappropriate request is sent successfully!
Failed to send your inappropiate request! Please login to send a feature request! Your feature quest has been sent successfuly! Error while send your feature request! Description: RNA Folding Simulation. RNA Folding Simulation An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use only and may not be sold or licensed nor shared on other sites.
While downloading, If for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. Slide 1 RNA FoldingSimulation by Giff Ransom Slide 2 Scientific Background RNA molecules are single stranded copies of a segment of a gene in the DNA. Slide 3 Slide 4 3D Simulation Slide 5 Kurt Grunberger, 2002 Slide 6. Error. Using RNA Nanotechnology to Treat Cancers and Viral Infections. DnaTube.com - Scientific Video and Animation Site. Realizing the promise of RNA nanotechnology for new drug development. Using RNA nanotechnology to treat cancers and viral infections: New study shows promise. Ultrastable RNA nanoparticles may help treat cancer and viral infections. New study shows promise in using RNA nanotechnology to treat cancers and viral infections. Broadcast Yourself. Broadcast Yourself. An Adapter Molecule; tRNA.
Plantbiology : Trends in Plant Science 'Plant... DEAD-box proteins function as recycling nanopistons when unwinding RNA. Ancient enzymes function like nanopistons to unwind RNA. Building blocks of RNA discovered around sun-like star. Broadcast Yourself. Broadcast Yourself. Broadcast Yourself. RNA Article. RNA Video. RNA Video. RNA Video. RNA Video. RNA Article. RNA Article. RNA Article. Organic Molecules DNA RNA | Cell Biology. Smallest RNA molecule engineered in CU's labs. Biology: Transfer RNA Role: Charging tRNA Molecule. Broadcast Yourself. RNA Article.
Researchers demonstrate how 'interfering' RNA can block bacterial evolution. Single-Stranded siRNAs Activate RNAi in Animals. Whosin. To cap or not to cap: Scientists find new RNA phenomenon that challenges dogma. DNA and RNA: structural comparison. Whole-transcriptome RNA-Seq analysis from archival FFPE tumor samples (Part 2) PLOSPathogens : RT @labratting: New post out... FurnoX: An RNA virus hijacks an incognito... FurnoX: Nonviral delivery of... Nonviral delivery of self-amplifying RNA vaccines. To cap or not to cap: Scientists find new RNA phenomenon that challenges dogma. KEY CONCEPT Transcription converts a gene into a single-stranded RNA molecule. Transcription & Translation: Translation (Advanced) Transcription & Translation: Translation (Basic)
SciReports : Widespread binding of FUS along... An RNA virus hijacks an incognito function of a DNA repair enzyme. RNA Structure - Time-saving Science Video by Brightstorm.