ResearchBlogs : Interacting small RNA path... EXPLORING THE INSIDE OF A VIRUS WITH A HELICAL CAPSID IN HD. NIH backs disease detectives and RNA sleuths. With the budget of the US National Institutes of Health (NIH) all but stagnant and grant-funding rates at historic lows, the agency’s wiggle room for spending decisions is increasingly tight. But one area in which agency director Francis Collins retains both discretion and dollar power is the NIH director’s Common Fund, a US$545-million pot of money for trans-institute, trans-disciplinary — and, hopefully, transformative — initiatives, each lasting no more than ten years. Today, Collins announced the latest two of these strategic deployments, both of which will launch in 2013. Building on a successful intramural programme that has generated lots of interest, one initiative is the Undiagnosed Diseases Program (UDP), which will fund extramural centres to work as detectives to diagnose mysterious maladies (see ‘Last chance clinic‘).
The UDP will receive $145 million over five years. New money is always fun, but there can be pain on the other end, when these big, one-time grants run out. Leclercfl : From DNA to Proteins From... Leclercfl : Phoenix: Molecular Biology... Leclercfl : Greatest Genetics Discover... Leclercfl : How spliceosomes splice RN... Leclercfl : Phoenix: Molecular Biology... A Glimpse of the RNA World: Ribozyme RNase P Bound with tRNA. Leclercfl : siRNA Pathway.flv siRNA Pa... Leclercfl : Origins of Life Through Or... Leclercfl : DNA 1/5 Secret Of Life (PB... Leclercfl : Greatest Genetics Discover... TibidyHealth : Speeding Up Genome Editing... TibidyHealth : Cells' Genetic History Eva... TibidyHealth : Speeding Up Genome Editing... TibidyHealth : Cells' Genetic History Eva... TibidyHealth : All about #RNAs. Tagged on... NatureBlogs : NIH backs disease detectiv... Leclercfl : Trudi Schupbach (Princeton... ScienceIndex_ : RNA-b... RNA Synthesis (Transcription), Part 5 of 9.
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DNA translation animation by Interact Medical. Leclercfl : Gene Regulation I Gene Reg... Sciencegoddess : Why we sunburn: When our s... ScienceIndex_ : Appea... Cancer_bio : Week in Review Ascletis In... Gene Regulation I. TibidyHealth : Targeting double-stranded... Leclercfl : RNA Synthesis (Transcripti... Vaccine_bio : Week in Review Ascletis In... TibidyHealth : First #Evidence For Target... TibidyHealth : All about #RNA. Tagged on... Interacting small RNA pathways in worms 1: Introduction | biobabel. A cluster of new papers, in the journals Cell and Science, discuss the links between piRNAs and various endogenous siRNA pathways in the nematode worm C. elegans. Emerging from these experiments is a picture of a genome-wide surveillance system capable of differentiating between self and non-self nucleic acids. The commonalities and differences between these papers require rather detailed analyses. I’m therefore intending to write a series of posts; first covering some of the background information on these small RNA systems and then getting onto the new findings.
A panoply of small RNA molecules, involved in diverse cellular functions have been discovered in the wake of the initial observation of RNA interference (RNAi). Originally RNAi described the mechanism by which genes could be specifically silenced by the exogenous application of cognate double-stranded RNAs. As noted above, the key effectors of these small RNA pathways are argonaute proteins. Ketting RF (2011). Like this: TibidyHealth : Sunburn Is Consequence Of... TibidyHealth : Sunburn Is Consequence Of... Mnt_healthnews : Sunburn Is Consequence Of... TibidyHealth : The Lungs Perceive #Hospit... Molecular Evolution: Genes And Proteins. Foresightnano : Atomically precise DNA-RNA... mRNA Translation (Basic) Leclercfl : mRNA Translation (Basic) m... TibidyHealth : Using Antiretrovirals To P... SciReports: Single-Molecule Electrical... Leclercfl : Greatest Genetics Discover...
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