Setup
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The first thing you need to organize before you can install WordPress, WordPress Multiste or BuddyPress is to organise your domain name and web hosting services. Now that you have set up your MySQL database and username you are ready to install WordPress or WordPress Multisite following the steps outlined below:
WordPress, WordPress Multisite and BuddyPress Installation - WPMU DEV – The WordPress Experts
Force WordPress network to use sub-directories
In WordPress 3.0, we have the ability to create a network of sites. But if your install is over 1 month old, the sites in your WordPress network must use sub-domains because of permalink problems with “/blog/” from the main site. This is how you can force the sites in your WordPress network to use sub-directories during the Network installation process. Creating this into a plugin is not an option, since all plugins are required to be deactivated before enabling the Network feature. Please read on how to Create A Network in the WordPress Codex and ticket #12931 for more information on why it is block by default.
How to Enable Multisite in WordPress | WordPress Theming
This video screencast is a quick tutorial for how to set up WordPress 3.0 in multisite mode. The WordPress codex has written instructions if you want to use those as well.
In WordPress 3.0 , you have the ability to create a network of sites (multisite). To enable the Network ability, you must first define multisite in the wp-config.php file. Note that because the Network ability requires a certain level of expertise, developers intentional require manual configuration of the wp-config.php file to enable Networks. To start the process of creating a Network, you first must tell WordPress to allow multisites, and by doing do enable the Network menu item to appear in the Tools menu. It is there you will configure certain aspects of your network. So first, edit the wp-config.php file and add the following line to the file:
Tools Network Screen « WordPress Codex
Create A Network « WordPress Codex
As of WordPress 3.0 , you have the ability to create a network of sites by using the multisite feature. This article contains instructions for creating a multisite network. A multisite network can be very similar to your own personal version of WordPress.com. End users of your network can create their own sites on demand, just like end users of WordPress.com can create blogs on demand.