Biology
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The Human Epigenome Browser at Washington University : Nature Methods : Nature Publishing Group
Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA. Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, Santa Cruz, California, USA.NHGRI Collection - International HapMap Project
In 2001, the International HapMap Consortium launched the International HapMap Project to develop a haplotype map (“HapMap”) of the human genome - a resource that describes the common patterns of human DNA sequence variation. The HapMap has become an important tool for researchers to use to find genes that affect health, disease, and response to drugs and environmental factors. All HapMap data are freely available to the public through the database dbSNP . A graphical browser for HapMap genotypes is also available at http://www.hapmap.org/cgi-perl/gbrowse/gbrowse . Further information can be found at the International HapMap Project website. The Project is also described at Nature 426 :789-796, 2003 [PMID: 14685227 ] .
The Galaxy Project: Online bioinformatics analysis for everyone
Data intensive biology for everyone. Galaxy is an open, web-based platform for data intensive biomedical research. Whether on the free public server or your own instance , you can perform, reproduce, and share complete analyses.
Comparative analysis of Alu repeats in primate genomes
Alu repeats are primate-specific short interspersed sequence elements (SINEs), ~300 nt in length, propagating within a genome through retrotransposition ( Schmid 1996 ). They are the most abundant repeat sequences found in humans, with more than 1.1 million copies accounting for ~10% of the human genome sequence ( Lander et al. 2001 ). Recent work increasingly recognizes that Alu elements have a greater impact than expected on phenotypic change, diseases, and evolution. Alu elements were demonstrated to mediate insertion mutagenesis, “exonization” by alternative splicing, genomic rearrangements, segmental duplication, and expression regulation causing disorders like Hunter syndrome, hemophilia A, and Sly syndrome ( Batzer and Deininger 2002 ). The oldest Alu elements were estimated to emerge either coincident with or immediately after the radiation of primates.
AluHunter is a suite of computer programs that automate the task of finding potentially polymorphic Alu elements for use in primate phylogenetics. Alu elements are a class of primate-specific SINEs . Throughout evolutionary time they've spread throughout the genome in a copy-and- paste mechanism. These insertions have two characteristics that make them ideal for use in primate systematics: they are nearly free of homoplasy and are of a known ancestral state . This means you can use Alu presence to distinguish between different primate evolutionary lineages. If two taxa share an Alu and a third does not, you know almost certainly that those first two taxa are more closely related to each other than they are to the third.
AluHunter by Christina Bergey - Information
Cambridge Evolutionary Genetics » Journal Club
Home » Journal Club The Evolutionary Genetics Journal Club takes place every two weeks during term breaks in the First Floor Seminar Room at the Department of Zoology (1 – 2 pm).
PCBP4
Funding
Welcome to the RNA Society. We’re a non-profit, international scientific society with more than 1000 members dedicated to fostering research and education in the field of RNA science. We host a peer-reviewed scientific journal, RNA, and an annual scientific conference, along with sponsoring other RNA-related scientific conferences through direct financial support and student travel grants. Mostly, we are a community of scientists who are passionate about better understanding the fascinating world of RNA biology. The RNA Society is pleased to announce that for the first time we will be offering a lifetime membership level.
The RNASociety WebSite
Marginal Revolution: Are bees more Bayesian?
It appears, therefore, that a swarm's scout bees do something sharply different from what humans do to reach a full agreement in a debate. Both bees and humans need a group's members to avoid stubbornly supporting their first view, but whereas we humans will usually (and sensibly) ive up on a position only after we have learned of a better one, the bees will stop supporting a position automatically. As is shown…after a shorter or longer time, each scout bee becomes silent and leaves the rest of the debate to a new set of bees.
Why can't you tell when an hour has passed without looking at a watch? Why are you able to do three things at once? Does coffee make time go faster? Neuroscientsts explain how our brains tell time - or don't.
How do you really know what time it is?
David H Bechhofer Professor David H Bechhofer joined Mount Sinai in 1986, after receiving his PhD from Columbia University in 1984 and doing postdoctoral work at the Public Health Research Institute of New York (moved since to UMDNJ in Newark, NJ). He is now Professor of Medical Education, and Professor of Pharmacology and Systems Therapeutics.
WIREs RNA - WIREs
Cohen Lab Home Page
T he ultimate goal of genetics, and therefore of genomics, is to understand the relationship between genotype (sequence) and phenotype (function). Our primary aim is to gain the ability to predict (and mathematically model) the phenotypic outcome of mutations (polymorphisms). Achieving this aim will depend critically on our ability to understand the interactions among the nucleic acids, proteins, and other metabolites that comprise genetic regulatory networks.the Node
(This interview originally appeared in Development .) The Latin American Society for Developmental Biology (LASDB) is getting ready for their Sixth International Meeting, which will be held in Montevideo, Uruguay, from April 26th to 29th, 2012. To find out more about the society, and about developmental biology in Latin America, we talked to LASDB president José Xavier Neto, who studies heart morphogenesis at the Laboratório Nacional de Biociências in Sao Paulo, Brazil. What are your research interests? I have been working on cardiac development ever since I was first trained in developmental biology.The Open Dinosaur Project
As mentioned in the previous post, a few papers with new or updated phylogenies for various ornithischians have appeared in the last year. Thus, I spent a few hours going through them and updating the tree topology as well as adding taxa. The phylogeny is given below, with notes on what I did at the end of the post. Note that many of the arbitrarily-resolved nodes aren’t that critical for some aspects of the analysis; they often include fragmentary taxa (sometimes only known from cranial material). We may wish to revise some of the resolutions in order to reduce ghost lineages. I have not yet incorporated Sterling Nesbitt’s most recent phylogeny of Archosauria, because I wasn’t able to successfully download the file.I'm a Scientist, Get me out of here!
I’m a Scientist is next running in June 2012. This is an X-factor style competition. Students talk to scientists online for 2 weeks and vote for their favourite scientist, in a nail-biting science show down.Databases
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