DOTA (chelator) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (also known as DOTA) is an organic compound with the formula (CH2CH2NCH2CO2H)4.
The molecule consists of a central 12-membered tetraaza (i.e., containing four nitrogen atoms) ring. DOTA is used as a complexing agent, especially for lanthanide ions. Its complexes have medical applications as contrast agents and cancer treatments. The acronym DOTA is jargon for both the tetracarboxylic acid and its various conjugate bases. In the area of coordination chemistry, the tetraacid is called H4DOTA and its fully deprotonated derivative is DOTA4–.[1] Many related ligands are referred to using the DOTA acronym, although these derivatives are generally not tetracarboxylic acids or the conjugate bases. As a polydentate ligand, DOTA envelops metal cations, but the denticity of the ligand depends on the geometric tendencies of the metal cation.
DOTA can also be linked to molecules that have affinity for various structures. Spitting Venom tab (ver 2) by Modest Mouse. People As Places As People tab by Modest Mouse. Ocean Breathes Salty tab (ver 2) by Modest Mouse. Float On tab (ver 7) by Modest Mouse. Dramamine tab (ver 3) by Modest Mouse. Dashboard tab (ver 3) by Modest Mouse. Tulips tab (ver 2) by Bloc Party. This Modern Love tab by Bloc Party. Hunting For Witches tab (ver 3) by Bloc Party. Helicopter tab (ver 7) by Bloc Party.
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