Rfam | RNA families. SwissRegulon. TFBS models | HOCOMOCO. We present the Homo Sapiens Comprehensive Model Collection (HOCOMOCO) of transcription factor (TF) binding models obtained by careful integration of data from different sources. HOCOMOCO contains 426 non-redundant curated binding models for 401 human TFs. DNA sequences of TF binding regions obtained by both pregenomic and high-throughput methods were collected from existing databases and other public data. The ChIPMunk software was used to construct positional weight matrices. Four motif discovery strategies were tested based on different motif shape priors including flat and periodic priors associated with DNA helix pitch. In any case only one model per TF was selected unless there was additional evidence for two distinct binding models or different stable modes of dimerization. More information is available in the Details section. CTCFBSDB 2.0: CTCF binding sites.
ChIPBase | regulation of long non-coding RNAs. FactorBook | TF binding data. Transcription factor classification. EPD The Eukaryotic Promoter Database.